Amyotrophic lateral sclerosis and history of skeletal fracture: A case‐control study
Abstract
A retrospective case-control study was conducted, using 66 amyotrophic lateral sclerosis (ALS) patients and 66 closely matched controls. Cases were ascertained primarily through a neurology clinic. A self-administered questionnaire probed for history of skeletal fractures. Using McNemar's test, no association was found between history of skeletal fracture and pathogenesis of ALS. No predilection for the head, neck, or spine was demonstrated. The extremities accounted for most fracture sites in cases and controls. Among cases, 68% of the fractures occurred before diagnosis, 58% occurring more than 10 years before diagnosis of ALS.
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Gresham et al. reported in their 1987 case-control study that there was no association between the development of ALS and skeletal fractures, even after taking into account the location of fractures.
“Gresham et al. also reported in their 1987 case–control study that there was no association between the development of ALS and skeletal fractures, even after taking into account the location of fractures [68].”
From Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry (2025) · cites this paper as [68]
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Head Injury and Amyotrophic Lateral Sclerosis
Chen, H., Richard, M., Sandler, D. P., Umbach, D. M., & Kamel, F. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm153 · Cited by 279 · see citing works
Turner, M. R., Abisgold, J., Yeates, D. G. R., Talbot, K., & Goldacre, M. J. (2010) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.10.010 · Cited by 55 · see citing works
Binazzi, A., Belli, S., Uccelli, R., Desiato, M. T., Talamanca, I. F., Antonini, G., Corsi, F., Scoppetta, C., Inghilleri, M., Pontieri, F., et al. (2008) · Amyotrophic Lateral Sclerosis · doi:10.1080/17482960802382313 · Cited by 46 · see citing works
Severe head injury and amyotrophic lateral sclerosis
Peters, T. L., Fang, F., Weibull, C. E., Sandler, D. P., Kamel, F., & Ye, W. (2013) · Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration · doi:10.3109/21678421.2012.754043 · Cited by 45 · see citing works
Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry
Raymond, J., Howard, I. M., Berry, J., Larson, T., Horton, D. K., & Mehta, P. (2025) · Brain Sciences · doi:10.3390/brainsci15020143 · Cited by 4 · see citing works
- Authors
- Gresham, L. S., Molgaard, C. A., Golbeck, A. L., & Smith, R.
- Affiliations
- Division of Epidemiology and Biostatistics (Ms. Gresham and Dr. Molgaard), Graduate School of Public Health, and the Department of Mathematical Sciences (Dr. Golbeck), San Diego State University; and the Center for Neurologic Study (Dr. Smith), San Diego, CA.
- Venue
- Neurology
- Published
- 1987-04
- Volume
- 37
- Issue
- 4
- Pages
- 717-717
- ISSN
- 0028-3878
- 1526-632X
- Cited by
- 19
- References
- 0
- Language
- en
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