Severe head injury and amyotrophic lateral sclerosis
Open accessAbstract
Our objective was to examine whether severe head injury, subtypes of head injury, or repeated head injuries are associated with ALS risk based on the Swedish population and health registers. We conducted a case-control study, nested within a cohort of 5,764,522 individuals who were born in Sweden during 1901-1970 and followed between 1991 and 2007. The study included 4004 ALS patients identified from the Swedish Patient Register during follow-up and 20,020 randomly selected controls matched by gender and birth year. We evaluated hospitalization for severe head injury that was recorded in the inpatient register before ALS diagnosis. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results showed that there was an association of ALS risk with severe head injury ≤ 1 year before diagnosis (OR: 3.9, 95% CI 2.6-6.1). No association was observed for severe head injury > 3 years before ALS diagnosis, nor was ALS associated with subtypes of head injury or repeated injuries occurring > 3 years before diagnosis. In conclusion, our findings from the Swedish registers provide no strong support for an etiological relationship between severe head injury in adulthood and ALS risk.
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In two studies, excess occurrence of head injury was significant only within 1 year after head injury, suggesting accidents provoked by early signs of ALS rather than ALS secondary to head trauma.
“However, in two studies excess occurrence was significant only within 1 year after head injury (Peters et al., 2013; Turner et al., 2010), rather suggesting accidents provoked by early signs of ALS than ALS secondary to head trauma (Turner et al., 2010).”
From Prevalence of potential sports‐associated risk factors in Swiss amyotrophic lateral sclerosis patients (2017) · cites this paper as Peters et al., 2013
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“However, in two studies excess occurrence was significant only within 1 year after head injury (Peters et al., 2013; Turner et al., 2010), rather suggesting accidents provoked by early signs of ALS than ALS secondary to head trauma (Turner et al., 2010).”
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- Authors
- Peters, T. L., Fang, F., Weibull, C. E., Sandler, D. P., Kamel, F., & Ye, W.
- Affiliations
- Karolinska Institutet (SE)
- National Institutes of Health (US)
- Corresponding author
- Peters, Tracy L.
- Ye, Weimin
- Venue
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- Publisher
- Informa UK Limited
- Published
- 2013-01-04
- Volume
- 14
- Issue
- 4
- Pages
- 267-272
- ISSN
- 2167-8421 (ISSN-L)
- 2167-9223
- PMC
- PMC5451091
- OpenAlex
- W2058706869
- Cited by
- 45
- References
- 30
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 9 · 2016: 3 · 2015: 6 · 2014: 2 · 2013: 1
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z01-ES049005)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- amyotrophic lateral sclerosis, severe traumatic brain injury, traumatic brain injury, repeated head injury, ALS risk factors
- MeSH terms
- Adult, Aged, Aged, 80 and over, Amyotrophic Lateral Sclerosis, Female, Follow-Up Studies, Craniocerebral Trauma, Humans, Male, Middle Aged, Registries, Risk Factors, Severity of Illness Index, Sweden, Cohort Studies, Case-Control Studies
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