Cited by 893Multiple Sclerosis Research StudiesCancer-related cognitive impairment studiesDementia and Cognitive Impairment Research

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Cognitive dysfunction in multiple sclerosis.: II. Impact on employment and social functioning

Rao, S. M., Leo, G. J., Ellington, L., Nauertz, T., Bernardin, L., Unverzagt, F.·1991·Neurology

DOI 10.1212/wnl.41.5.692

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Abstract

We designed a study to assess the specific contribution of cognitive dysfunction to multiple sclerosis patients' problems in daily living. Based on the results of a comprehensive neuropsychological test battery, we classified 100 MS patients as either cognitively intact (N = 52) or cognitively impaired (N = 48). In addition to a neurologic examination, MS patients completed questionnaires on mood and social functioning, underwent a comprehensive in-home occupational therapy evaluation, and were rated by a close relative or friend regarding specific personality characteristics. While there were no significant differences between the two groups on measures of physical disability and illness duration, patients in the cognitively impaired group were less likely to be working, engaged in fewer social and avocational activities, reported more sexual dysfunction, experienced greater difficulty in performing routine household tasks, and exhibited more psychopathology than cognitively intact patients. These findings suggest that cognitive dysfunction is a major factor in determining the quality of life of patients with MS.

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Authors: Rao, S. M., Leo, G. J., Ellington, L., Nauertz, T., Bernardin, L., & Unverzagt, F.
Affiliations: Medical College of Wisconsin (US)
ORCID: Rao, S. M.
Ellington, L.
Unverzagt, F.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1991-05
Volume: 41
Issue: 5
Pages: 692-696
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.41.5.692
OpenAlex: W2007948644
Cited by: 890
References: 0
Citations by year: 2026: 15 · 2025: 14 · 2024: 14 · 2023: 13 · 2022: 21 · 2021: 31 · 2020: 35 · 2019: 26 · 2018: 30 · 2017: 42 · 2016: 40 · 2015: 43 · 2014: 33 · 2013: 41 · 2012: 42
FWCI: 6.04
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Neurological Disorders and Stroke (K04 NS01055-04, K04NS001055, R01 NS22128-05, R01NS022128)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: multiple sclerosis, cognitive impairment, activities of daily living, quality of life, occupational therapy, mood, social functioning, sexual dysfunction, psychopathology, housework, work participation
MeSH terms: Activities of Daily Living, Adult, Cognition, Cognition Disorders, Demography, Employment, Female, Humans, Male, Multiple Sclerosis, Reference Values, Social Behavior, Case-Control Studies

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Cognitive dysfunction in multiple sclerosis.: II. Impact on employment and social functioning

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