Quality of life in multiple sclerosis in France, Germany, and the United Kingdom
Open accessAbstract
OBJECTIVE: To assess the quality of life (QoL) of patients with multiple sclerosis in France, Germany, and the United Kingdom with a cross sectional study. METHODS: Patients were classified into three severity groups according to the expanded disability severity scale (EDSS); stage I, II, and III, corresponding to mild (EDSS 1.0-3.5), moderate (EDSS 4.0-6.0), or severe (EDSS 6.5-8.0) multiple sclerosis respectively. Ninety patients with multiple sclerosis and 30 control patients without multiple sclerosis were recruited in each country. Control patients were matched to the patients with multiple sclerosis according to age and sex. Quality of life was assessed using the functional status questionnaire (FSQ). RESULTS: The aspects of QoL that were mostly affected in the three countries under study were physical function and general wellbeing. Social role function decreased with increased severity of disease in France and in particular in Germany. Multiple sclerosis did not seem to have an impact on psychological function. The QoL of control patients was systematically higher than that of patients with multiple sclerosis. CONCLUSIONS: Use of such a generic scale showed that progression of multiple sclerosis is accompanied by a decrease in QoL and suggested that this could be a relevant measurement in assessing the effect of treatment and progression of disease. Variation between countries, however, may be important.
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HRQOL psychosocial impairment is, to an important degree, independent of extent of disease among patients with multiple sclerosis.
“HRQOL psychosocial impairment shows great variation among patients with MS and is, to an important degree, independent of extent of disease.6–10”
From MS quality of life, depression, and fatigue improve after mindfulness training: A randomized trial (2010) · cites this paper as [8]
The MAIN SCALES and Discussion sections (page unavailable) report that psychological function was lower in patients with MS than in controls but did not correlate with disease severity. The claim is broader than that finding: social role function, another psychosocial measure, was associated with severity in some countries, and the paper does not establish that psychosocial impairment generally varies greatly between patients. (LLM, conf=0.87)
Experimental — accuracy not yet measuredHRQOL psychosocial impairment shows great variation among patients with multiple sclerosis.
“HRQOL psychosocial impairment shows great variation among patients with MS and is, to an important degree, independent of extent of disease.6–10”
From MS quality of life, depression, and fatigue improve after mindfulness training: A randomized trial (2010) · cites this paper as [8]
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Grossman, P., Kappos, L., Gensicke, H., D'Souza, M., Mohr, D. C., Penner, I. K., & Steiner, C. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f4d80d · Cited by 419 · see citing works
Janssens, A. C. J. W., van Doorn, P. A., de Boer, J. B., van der Meché, F. G. A., Passchier, J., & Hintzen, R. Q. (2003) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2003.00166.x · Cited by 294 · see citing works
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Minden, S. L., Frankel, D., Hadden, L., Perloff, J., Srinath, K. P., & Hoaglin, D. C. (2006) · Multiple Sclerosis Journal · doi:10.1191/135248506ms1262oa · Cited by 272 · see citing works
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- Authors
- Murphy, N., Confavreux, C., Haas, J., Konig, N., Roullet, E., Sailer, M., Swash, M., Young, C., & J-L, M.
- Corresponding author
- Murphy, N
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1998-10-01
- Volume
- 65
- Issue
- 4
- Pages
- 460-466
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC2170316
- OpenAlex
- W2135934250
- Cited by
- 119
- References
- 2
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 4 · 2015: 5 · 2013: 5 · 2012: 2
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- multiple sclerosis, quality of life, disease severity, Expanded Disability Status Scale, functional status, psychological functioning, cross-national comparison, France, Germany, United Kingdom
- MeSH terms
- Adult, Cross-Sectional Studies, Female, France, Germany, United Kingdom, Humans, Male, Middle Aged, Multiple Sclerosis, Quality of Life, Surveys and Questionnaires, Severity of Illness Index
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