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Mild cognitive impairment in the elderly: Predictors of dementia
Abstract
We conducted full diagnostic evaluations, including a comprehensive cognitive assessment battery, of a group of 32 elderly subjects with a clinically identified mild cognitive impairment and a group of 32 age-matched and education-matched normal subjects. The mildly impaired subjects performed significantly more poorly than the controls on tests of recent memory, remote memory, language function, concept formation, and visuospatial praxis. Follow-up evaluations of cognitive status 2 years later revealed clinically detectable cognitive decline relative baseline in 23 (72%) of the mildly impaired subjects. Several of the objective psychological tests accurately discriminated at baseline between the decliners and nondecliners in the mildly impaired group. Among the 20 mildly impaired subjects with no complicating conditions, 16 exhibited cognitive deterioration between baseline and follow-up. These results suggest that most elderly subjects with mild cognitive deficits, as determined by clinical evaluation and objective psychological testing, will manifest the progressive mental deterioration characteristic of dementia and that psychometric predictors can be used to distinguish between benign and more significant underlying disorders in mildly impaired elderly subjects.
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“This intermediate state has been termed mild cognitive impairment (MCI) and clinical criteria for this diagnosis have been suggested(1–3).”
From Rates of hippocampal atrophy correlate with change in clinical status in aging and AD (2000) · cites this paper as [3]
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Mild Cognitive Impairment: Clinical Characterization and Outcome
Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., & Kokmen, E. (1999) · Archives of Neurology · doi:10.1001/archneur.56.3.303 · Cited by 8,980
Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria
Dubois, B., Feldman, H. H., Jacova, C., DeKosky, S. T., Barberger-Gateau, P., Cummings, J., Delacourte, A., Galasko, D., Gauthier, S., Jicha, G., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70178-3 · Cited by 4,411
Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 4,094
Self-citationRandolph, C., Tierney, M. C., Mohr, E., & Chase, T. N. (1998) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.20.3.310.823 · Cited by 2,519
Metadata
- Authors
- Flicker, C., Ferris, S. H., & Reisberg, B.
- Affiliations
- NYU Langone Health (US)
- Venue
- Neurology
- Published
- 1991-07
- Volume
- 41
- Issue
- 7
- Pages
- 1006-1006
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2008180577
- Cited by
- 838
- References
- 0
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 14 · 2023: 14 · 2022: 10 · 2021: 18 · 2020: 24 · 2019: 28 · 2018: 19 · 2017: 18 · 2016: 21 · 2015: 32 · 2014: 23 · 2013: 28 · 2012: 31
- FWCI
- 7.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh040410-02)
- National Institute on Aging (AG03051, R01AG003051)
- National Institute of Mental Health (MH 40410)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- mild cognitive impairment, older adults, cognitive decline, dementia, memory impairment, language functions, concept formation, cognitive assessment, longitudinal follow-up
- MeSH terms
- Aged, Aging, Cognition Disorders, Dementia, Humans, Longitudinal Studies, Neuropsychological Tests, Prognosis, Psychiatric Status Rating Scales
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