Cited by 574Asthma and respiratory diseasesOccupational exposure and asthmaRespiratory and Cough-Related Research

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Alternative excitotoxic hypotheses

Albin, Roger L., Greenamyre, J. Timothy·1992·Neurology

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Abstract

It is known that asthma is a heterogeneous entity whose manifestations vary with age. Our objective was to examine changes in the manifestation of asthma and asthma-related traits in childhood by defining empirically derived childhood asthma phenotypes and examining their transitions over time. To define the phenotypes we used data on respiratory symptoms, healthcare utilisation, medications, spirometry, airway hyperresponsiveness (AHR), exhaled nitric oxide concentration and atopy from a birth cohort recruited on the basis of having a first-degree relative with asthma. Data were acquired at ages 1.5–11.5 years and analysed using latent transition analysis. In a study population of 370 participants, we classified subjects into four phenotypes: 1) nonatopic, few symptoms (prevalence range from 1.5 to 5 years: 52–60%), 2) atopic, few symptoms (3–21%), 3) nonatopic, asthma and rhinitis symptoms (13–35%), and 4) atopic, asthma and rhinitis symptoms (2–14%) in early childhood; and 1) nonatopic, no respiratory disease (prevalence range from 8 to 11.5 years: 41–46%), 2) atopic, no respiratory disease (23–33%), 3) nonatopic, asthma symptoms, no AHR or airway inflammation (8–12%) and 4) atopic asthma (19%) in mid-childhood. Transitioning between phenotypes was common in early childhood, but less common in later childhood. This analysis represents the first attempt to incorporate longitudinal patterns of several manifestations of asthma into a single model to simultaneously define phenotypes and examine their transitions over time. It provides quantitative support for the view that asthma is a heterogeneous entity, and that some children with wheeze and other respiratory symptoms in early life progress to asthma in mid-childhood, while others become asymptomatic.

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The messenger RNAs for the N-methyl- d-aspartate receptor subunits show region-specific expression of different subunit composition in the human brain
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“…excitotoxic hypothesis predicts that a partial reduction in energy stores (ATP/ADP), compromised Na + ,K + -ATPase activity, and a deteriorating membrane potential may contribute to loss of regulation at the NMDA receptor via loss of the voltage-sensitive Mg 2+ - channel blockade (5, 95, 108, 264).”
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Authors: Albin, R. L., & Greenamyre, J. T.
Affiliations: University of Michigan (US)
University of Rochester (US)
ORCID: Albin, Roger L.
Greenamyre, J. Timothy
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1992-04
Volume: 42
Issue: 4
Pages: 733-733
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.42.4.733
OpenAlex: W2058176457
Cited by: 574
References: 0
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 18 · 2021: 4 · 2020: 12 · 2019: 3 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 4 · 2014: 10 · 2013: 12 · 2012: 16
FWCI: 14.01
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k08ns001300-03, 5k08ns001487-03)
National Institute of Neurological Disorders and Stroke (NS01300, NS 01487)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory and Cough-Related Research
Keywords: asthma phenotypes, childhood asthma, asthma heterogeneity, phenotype transition, atopy, rhinitis, airway hyperresponsiveness, exhaled nitric oxide, wheezing, latent transition analysis, birth cohort
MeSH terms: Acute Disease, Amino Acids, Chronic Disease, Humans, Models, Neurological, Nerve Degeneration, Nervous System Diseases, Neurology, Neurotoxins, Receptors, Cell Surface, Receptors, Amino Acid

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