Cited by 1,272Heart Rate Variability and Autonomic ControlVagus Nerve Stimulation ResearchEpilepsy research and treatment

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Cardiovascular effects of human insular cortex stimulation

Oppenheimer, Stephen M., Gelb, Adrian, Girvin, John P., Hachinski, Vladimir C.·1992·Neurology

DOI 10.1212/wnl.42.9.1727

Open this paper in CoChat — free account

Abstract

Recent investigations indicate a site of cardiac representation within the left insular cortex of the rat. Moreover, the results of lesion studies suggest left-sided insular dominance for sympathetic cardiovascular effects. It is unclear whether similar representation exists within the human insular cortex. Five epileptic patients underwent intraoperative insular stimulation prior to temporal lobectomy for seizure control. On stimulation of the left insular cortex, bradycardia and depressor responses were more frequently produced than tachycardia and pressor effects (p less than 0.005). The converse applied for the right insular cortex. We believe this to be the first demonstration of cardiovascular changes elicitable during insular stimulation in humans, and of lateralization of such responses for a cortical site. In humans, unlike the rat, there appears to be right-sided dominance for sympathetic effects. These findings may be of relevance in predicting the autonomic effects of stroke in humans and in the explanation of sudden unexpected epileptic death.

Integrity signals

Registry

Crossref · 10.1212/wnl.42.9.1727

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The Cerebral Cortex of Man: A Clinical Study of Localization of Function
(1968) · JAMA · doi:10.1001/jama.1968.03150020096041 · Cited by 1,218
Insula of the old world monkey. III: Efferent cortical output and comments on function
Mesulam, M. ‐., & Mufson, E. J. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902120104 · Cited by 1,013
Insula of the old world monkey. Architectonics in the insulo‐orbito‐temporal component of the paralimbic brain
Mesulam, M. M., & Mufson, E. J. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120102 · Cited by 660
Somato-motor, autonomic and electrocorticographic responses to electrical stimulation of rhinencephalic and other structures in primates, cat, and dog; a study of responses from the limbic, subcallosal, orbito-insular, piriform and temporal cortex, hippocampus-fornix and amygdala.
Kaada, B. R. (1951) · PubMed · Cited by 549
Early mortality following stroke: a prospective review.
Silver, F. L., Norris, J. W., Lewis, A., & Hachinski, V. C. (1984) · Stroke · doi:10.1161/01.str.15.3.492 · Cited by 485
Self-citation
Autonomic responses and efferent pathways from the insular cortex in the rat
Yasui, Y., Breder, C. D., Safer, C. B., & Cechetto, D. F. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903030303 · Cited by 480
Basis for Recurring Ventricular Fibrillation in the Absence of Coronary Heart Disease and Its Management
Lown, B., Temte, J. V., Reich, P., Gaughan, C. E., Regestein, Q. R., & Hai, H. A. (1976) · New England Journal of Medicine · doi:10.1056/nejm197603182941201 · Cited by 374
Cerebrogenic Cardiac Arrhythmias
Oppenheimer, S. M. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530050029008 · Cited by 325
Self-citation
Insular cortex stimulation produces lethal cardiac arrhythmias: a mechanism of sudden death?
Oppenheimer, S. M., Wilson, J. X., Guiraudon, C., & Cechetto, D. F. (1991) · Brain Research · doi:10.1016/0006-8993(91)90412-o · Cited by 298
Self-citation
Cardiac chronotropic organization of the rat insular cortex
Oppenheimer, S. M., & Cechetto, D. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91796-j · Cited by 270
Self-citation

Show all 22 references

Sorted by citations

Items 201–300 of 998

Sympathetic influence on cerebral blood flow and metabolism during exercise in humans
Seifert, T., & Secher, N. H. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.09.008 · Cited by 104
An insula hierarchical network architecture for active interoceptive inference
Fermin, A. S. R., Friston, K., & Yamawaki, S. (2022) · Royal Society Open Science · doi:10.1098/rsos.220226 · Cited by 101
The pathophysiology of cardiac dysfunction in epilepsy
Ravindran, K., Powell, K. L., Todaro, M., & O'Brien, T. J. (2016) · Epilepsy Research · doi:10.1016/j.eplepsyres.2016.08.007 · Cited by 101
Detection of epileptic seizures with a modified heart rate variability algorithm based on Lorenz plot
Jeppesen, J., Beniczky, S., Johansen, P., Sidenius, P., & Fuglsang‐Frederiksen, A. (2014) · Seizure · doi:10.1016/j.seizure.2014.11.004 · Cited by 101
The Structural Connectome of the Human Central Homeostatic Network
Edlow, B. L., McNab, J. A., Witzel, T., & Kinney, H. C. (2015) · Brain Connectivity · doi:10.1089/brain.2015.0378 · Cited by 99
Functional magnetic resonance imaging responses to expiratory loading in obstructive sleep apnea
Macey, P. M., Macey, K. E., Henderson, L. A., Alger, J. R., Frysinger, R. C., Woo, M. A., Yan‐Go, F. L., & Harper, R. M. (2003) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2003.09.002 · Cited by 100
Regional Brain Activation Due to Pharmacologically Induced Adrenergic Interoceptive Stimulation in Humans
Cameron, O. G., & Minoshima, S. (2002) · Psychosomatic Medicine · doi:10.1097/01.psy.0000038939.33335.32 · Cited by 99
Cellular activity in insular cortex across seconds to hours: Sensations and predictions of bodily states
Livneh, Y., & Andermann, M. L. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.036 · Cited by 105
Brain Activation During Detrusor Overactivity in Patients With Parkinson’s Disease: A Positron Emission Tomography Study
Kitta, T., Κakizaki, H., Furuno, T., Moriya, K., Tanaka, H., Shiga, T., Tamaki, N., Yabe, I., Sasaki, H., & Nonomura, K. (2006) · The Journal of Urology · doi:10.1016/s0022-5347(05)00324-1 · Cited by 98
Forebrain neurocircuitry associated with human reflex cardiovascular control
Shoemaker, J. K., & Goswami, R. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00240 · Cited by 101
Antihypertensive treatment can prevent stroke and cognitive decline
Sörös, P., Whitehead, S. N., Spence, J. D., & Hachinski, V. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.255 · Cited by 99
Self-citation
Insular lateralization in tinnitus distress
van der Loo, E., Congedo, M., Vanneste, S., de Heyning, P. V., & Ridder, D. D. (2011) · Autonomic Neuroscience · doi:10.1016/j.autneu.2011.06.007 · Cited by 101
Apotemnophilia: a neurological disorder
Brang, D., McGeoch, P. D., & Ramachandran, V. S. (2008) · Neuroreport · doi:10.1097/wnr.0b013e32830abc4d · Cited by 97
Interictal Cardiovascular Autonomic Responses in Patients with Epilepsy
Isojärvi, J. I. T., Ansakorpi, H., Suominen, K., Tolonen, U., Repo, M., & Myllylä, V. V. (1998) · Epilepsia · doi:10.1111/j.1528-1157.1998.tb01394.x · Cited by 97
Finding the missing link between ictal bradyarrhythmia, ictal asystole, and sudden unexpected death in epilepsy
Leung, H., Kwan, P., & Elger, C. E. (2006) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2006.05.009 · Cited by 96
Brain–heart crosstalk: the many faces of stress-related cardiomyopathy syndromes in anaesthesia and intensive care
Mazzeo, A. T., Micalizzi, A., Mascia, L., Scicolone, A., & Siracusano, L. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu046 · Cited by 97
Human cerebral circuitry related to cardiac control: a neuroimaging meta-analysis
Ruiz Vargas, E., Sörös, P., Shoemaker, J. K., & Hachinski, V. (2016) · Annals of Neurology · doi:10.1002/ana.24642 · Cited by 94
Self-citation
Prognostic Significance of Infarct Size and Location: The Case of Insular Stroke
Laredo, C., Zhao, Y., Rudilosso, S., Renú, A., Pariente, J. C., Chamorro, Á., & Urra, X. (2018) · Scientific Reports · doi:10.1038/s41598-018-27883-3 · Cited by 100
Relative Changes in Regional Cerebral Blood Flow During Spinal Cord Stimulation in Patients with Refractory Angina Pectoris
Hautvast, R. W. M., Horst, G. J. T., de Jong, B. M., DeJongste, M. J. L., Blanksma, P. K., Paans, A. M. J., & Korf, J. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01472.x · Cited by 94
Modulation of cardiac autonomic balance with adjuvant yoga therapy in patients with refractory epilepsy
Sathyaprabha, T. N., Satishchandra, P., Pradhan, C., Sinha, S., Kaveri, B., Thennarasu, K., Murthy, B. T. C., & Raju, T. R. (2007) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2007.09.006 · Cited by 93
Changes of circadian blood pressure patterns and cardiovascular parameters indicate lateralization of sympathetic activation following hemispheric brain infarction
Sander, D., & Klingelh�fer, J. (1995) · Journal of Neurology · doi:10.1007/bf00878874 · Cited by 93
The autonomic-related cortex: pathology in Alzheimer's disease
Chu, C. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.1.86 · Cited by 91
Brain aging patterns in a large and diverse cohort of 49,482 individuals
Yang, Z., Wen, J., Erus, G., Govindarajan, S. T., Melhem, R., Mamourian, E., Cui, Y., Srinivasan, D., Abdulkadir, A., Parmpi, P., et al. (2024) · Nature Medicine · doi:10.1038/s41591-024-03144-x · Cited by 102
How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures?
Moseley, B. D., Nickels, K. C., Britton, J. W., & Wirrell, E. C. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2009.02490.x · Cited by 91
Impaired Baroreceptor Reflex Sensitivity in Acute Stroke Is Associated With Insular Involvement, But Not With Carotid Atherosclerosis
Sykora, M., Diedler, J., Rupp, A., Turčáni, P., & Steiner, T. (2009) · Stroke · doi:10.1161/strokeaha.108.519967 · Cited by 91
Patterns of Brain Activation during Visually Evoked Sexual Arousal Differ between Homosexual and Heterosexual Men
Hu, S., Wei, N., Wang, Q.-D., Yan, L.-Q., Wei, E., Zhang, M.-M., Hu, J., Huang, M., Zhou, W.-H., & Xu, Y. (2008) · American Journal of Neuroradiology · doi:10.3174/ajnr.a1260 · Cited by 94
Sphenopalatine ganglion neuromodulation in migraine: What is the rationale?
Khan, S., Schoenen, J. E., & Ashina, M. (2013) · Cephalalgia · doi:10.1177/0333102413512032 · Cited by 91
Cardiac Dysfunction After Left Permanent Cerebral Focal Ischemia
Min, J., Farooq, M. U., Greenberg, E. J., Aloka, F., Bhatt, A., Kassab, M. Y., Morgan, J. P., & Majid, A. (2009) · Stroke · doi:10.1161/strokeaha.108.536086 · Cited by 90
Inspiratory loading elicits aberrant fMRI signal changes in obstructive sleep apnea
Macey, K. E., Macey, P. M., Woo, M. A., Henderson, L. A., Frysinger, R. C., Harper, R. K., Alger, J. R., Yan‐Go, F. L., & Harper, R. M. (2005) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2005.05.024 · Cited by 91
Prevalence and Characterization of ECG Abnormalities After Intracerebral Hemorrhage
van Bree, Roos, Y. B. W. E. M., van der Bilt, I. A. C., Wilde, A. A. M., Sprengers, M. E. S., de Gans, K., & Vergouwen, M. D. I. (2009) · Neurocritical Care · doi:10.1007/s12028-009-9283-z · Cited by 89
Seizure induced cardiac asystole in epilepsy patients undergoing long term video-EEG monitoring
Lanz, M., Oehl, B., Brandt, A., & Schulze‐Bonhage, A. (2010) · Seizure · doi:10.1016/j.seizure.2010.11.017 · Cited by 89
Autonomic consequences of kainic acid–induced limbic cortical seizures in rats: Peripheral autonomic nerve activity, acute cardiovascular changes, and death
Sakamoto, K., Saito, T., Orman, R., Koizumi, K., Lazar, J., Salciccioli, L. F., & Stewart, M. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01545.x · Cited by 88
Forebrain organization for autonomic cardiovascular control
Shoemaker, J. K., Norton, K. N., Baker, J. R., & Luchyshyn, T. (2014) · Autonomic Neuroscience · doi:10.1016/j.autneu.2014.10.022 · Cited by 88
Bradycardia in neurosurgery
Agrawal, A., Timothy, J., Cincu, R., Agarwal, T., & Waghmare, L. (2008) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2008.01.013 · Cited by 88
Abnormalities in cardiac and respiratory function observed during seizures in childhood
O’Regan, M., & Brown, J. K. (2005) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162205000022 · Cited by 88
A Review of Neurogenic Stunned Myocardium
Biso, S. M. R., Wongrakpanich, S., Agrawal, A., Yadlapati, S., Kishlyansky, M., & Figueredo, V. M. (2017) · Cardiovascular Psychiatry and Neurology · doi:10.1155/2017/5842182 · Cited by 88
Individual differences in socioemotional sensitivity are an index of salience network function
Toller, G., Brown, J. A., Sollberger, M. A., Shdo, S. M., Bouvet, L., Sukhanov, P., Seeley, W. W., Miller, B. L., & Rankin, K. P. (2018) · Cortex · doi:10.1016/j.cortex.2018.02.012 · Cited by 90
Brain activity and perceived exertion during cycling exercise: an fMRI study
Fontes, E. B., Okano, A. H., Guio, F. D., Schabort, E. J., Li, L. M., Basset, F. A., Stein, D. J., & Noakes, T. D. (2013) · British Journal of Sports Medicine · doi:10.1136/bjsports-2012-091924 · Cited by 94
Takotsubo-Like Myocardial Dysfunction in Ischemic Stroke
Jung, J., Kim, J.-G., Kim, J. B., Cho, K., Yu, S., Oh, K., Kim, Y., Choi, J., & Seo, W. (2016) · Stroke · doi:10.1161/strokeaha.116.014304 · Cited by 88
Cortical and brain stem changes in neural activity during static handgrip and postexercise ischemia in humans
Sander, M., Macefield, V. G., & Henderson, L. A. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91539.2008 · Cited by 87
Cerebral Autoregulation and Syncope
Folino, A. F. (2007) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2007.01.001 · Cited by 85
Abnormalities in cardiac and respiratory function observed during seizures in childhood
O’Regan, M., & Brown, J. K. (2007) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2005.tb01033.x · Cited by 85
Differential responses of the insular cortex gyri to autonomic challenges
Macey, P. M., Wu, P., Kumar, R., Ogren, J. A., Richardson, H. L., Woo, M. A., & Harper, R. M. (2012) · Autonomic Neuroscience · doi:10.1016/j.autneu.2012.01.009 · Cited by 84
Baroreflex modulation during sleep and in obstructive sleep apnea syndrome
Cortelli, P., Lombardi, C., Montagna, P., & Parati, G. (2012) · Autonomic Neuroscience · doi:10.1016/j.autneu.2012.02.005 · Cited by 84
Dysfunctional Brain Networking among Autonomic Regulatory Structures in Temporal Lobe Epilepsy Patients at High Risk of Sudden Unexpected Death in Epilepsy
Allen, L. A., Harper, R. M., Kumar, R., Guye, M., Ogren, J. A., Lhatoo, S. D., Lemieux, L., Scott, C. A., Vos, S. B., Rani, S., et al. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00544 · Cited by 88
Ictal asystole: A systematic review
Tényi, D., Gyimesi, C., Kupó, P., Horváth, R. A., Bóné, B., Barsi, P., Kovács, N., Símor, T., Siegler, Z., Környei, L., et al. (2016) · Epilepsia · doi:10.1111/epi.13644 · Cited by 84
The anterior insular cortex unilaterally controls feeding in response to aversive visceral stimuli in mice
Wu, Y., Chen, C., Chen, M., Qian, K., Lv, X., Wang, H., Jiang, L., Yu, L., Zhuo, M., & Qiu, S. (2020) · Nature Communications · doi:10.1038/s41467-020-14281-5 · Cited by 87
Cardiac Effects of Seizures
Nei, M. (2009) · Epiliepsy currents/Epilepsy currents · doi:10.1111/j.1535-7511.2009.01303.x · Cited by 83
Characterization of baroreceptor-related neurons in the monkey insular cortex
Zhang, Z.-H., Dougherty, P. M., & Oppenheimer, S. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00268-6 · Cited by 83
Self-citation
Ictal Asystole and Ictal Syncope
Bestawros, M. T., Darbar, D., Arain, A. M., Abou-Khalil, B. W., Plummer, D., Dupont, W. D., & Raj, S. R. (2014) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.114.001667 · Cited by 82
Influence of Stroke Localization on Autonomic Activation, Immunodepression, and Post-Stroke Infection
Harms, H., Reimnitz, P., Böhner, G., Werich, T., Klingebiel, R., Meisel, C., & Meisel, A. (2011) · Cerebrovascular Diseases · doi:10.1159/000331922 · Cited by 81
Network Architecture Underlying Basal Autonomic Outflow: Evidence from Frontotemporal Dementia
Sturm, V. E., Brown, J. A., Hua, A. Y., Lwi, S. J., Zhou, J. H., Kurth, F., Eickhoff, S. B., Rosen, H. J., Kramer, J. H., Miller, B. L., et al. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0347-18.2018 · Cited by 84
A possible mechanism for PTSD symptoms in patients with traumatic brain injury: central autonomic network disruption
Williamson, J. B., Heilman, K. M., Porges, E. C., Lamb, D. G., & Porges, S. W. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00013 · Cited by 81
Vestibular responses to direct stimulation of the human insular cortex
Mazzola, L., Christophe Lopez, A., Faillenot, I., Chouchou, F., Mauguı̀ere, F., & Isnard, J. (2014) · Annals of Neurology · doi:10.1002/ana.24252 · Cited by 80
Impaired heart rate variability in euthymic bipolar patients
Cohen, H., Kaplan, Z., Kotler, M., Mittelman, I., Osher, Y., & Bersudsky, Y. (2003) · Bipolar Disorders · doi:10.1034/j.1399-5618.2003.00027.x · Cited by 81
Ictal heart rate increase precedes EEG discharge in drug-resistant mesial temporal lobe seizures
Gennaro, G. D., Quarato, P. P., Sebastiano, F., Esposito, V., Onorati, P., Grammaldo, L. G., Meldolesi, G., Mascia, A., Falco, C. D., Scoppetta, C., et al. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2003.12.016 · Cited by 80
Wisconsin Card Sorting in adolescents: analysis of performance, response times and heart rate
Somsen, R. J. M., van der Molen, M. W., Jennings, J. R., & van Beek, B. (2000) · Acta Psychologica · doi:10.1016/s0001-6918(00)00030-5 · Cited by 79
Panic attack semiology in right temporal lobe epilepsy
Sazgar, M., Carlen, P. L., & Wennberg, R. A. (2003) · Epileptic Disorders · doi:10.1684/j.1950-6945.2003.tb00569.x · Cited by 79
Identification of the human sympathetic connectome involved in blood pressure regulation
Macefield, V. G., & Henderson, L. A. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116119 · Cited by 74
Sex differences in forebrain and cardiovagal responses at the onset of isometric handgrip exercise: a retrospective fMRI study
Wong, S. W. H., Kimmerly, D. S., Massé, N., Menon, R. S., Cechetto, D. F., & Shoemaker, J. K. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00171.2007 · Cited by 77
Does Hemispheric Lateralization Influence Functional and Cardiovascular Outcomes After Stroke?
Fink, J., FRAMPTON, C. M. A., Lyden, P. D., & Lees, K. R. (2008) · Stroke · doi:10.1161/strokeaha.108.523365 · Cited by 78
Activation of the supplementary motor area (SMA) during voluntary pelvic floor muscle contractions—An fMRI study
Kuhtz-Buschbeck, J. P., van der Horst, C., Wolff, S., Filippow, N., Nabavi, A., Jansen, O., & Braun, P. M. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.032 · Cited by 77
Neural alterations associated with anxiety symptoms in obstructive sleep apnea syndrome
Kumar, R., Macey, P. M., Cross, R. L., Woo, M. A., Yan‐Go, F. L., & Harper, R. M. (2008) · Depression and Anxiety · doi:10.1002/da.20531 · Cited by 77
Physical exercise in overweight to obese individuals induces metabolic- and neurotrophic-related structural brain plasticity
Mueller, K., Möller, H. E., Horstmann, A., Busse, F. P., Lepsien, J., Blüher, M., Stümvoll, M., Villringer, A., & Pleger, B. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00372 · Cited by 77
Limitation of physical performance in a muscle fatiguing handgrip exercise is mediated by thalamo‐insular activity
Hilty, L., Jäncke, L., Luechinger, R., Boutellier, U., & Lutz, K. (2010) · Human Brain Mapping · doi:10.1002/hbm.21177 · Cited by 80
Physiological and neuropsychological correlates of hostility
Demaree, H. A., & Harrison, D. W. (1997) · Neuropsychologia · doi:10.1016/s0028-3932(97)00053-5 · Cited by 75
Morphologic determinants in the etiology of class III malocclusions: A review
Singh, G. D. (1999) · Clinical Anatomy · doi:10.1002/(sici)1098-2353(1999)12:5 · Cited by 113
Partial Epileptic Seizures of Different Origin Variably Affect Cardiac Rhythm
Galimberti, C. A., Marchioni, E., Barzizza, F., Manni, R., Sartori, I., & Tartara, A. (1996) · Epilepsia · doi:10.1111/j.1528-1157.1996.tb00645.x · Cited by 75
Ecstatic Epileptic Seizures: A Glimpse into the Multiple Roles of the Insula
Gschwind, M., & Picard, F. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00021 · Cited by 78
Transient blood pressure changes affect the functional magnetic resonance imaging detection of cerebral activation
Wang, R., Foniok, T., Cusulin, J. I. W., Qiao, M., Tomanek, B., Vivanco, R. A., & Tuor, U. I. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.12.004 · Cited by 74
Cardiac Arrhythmias and Sudden Unexpected Death in Epilepsy (SUDEP)
Velagapudi, P., Turagam, M. K., Laurence, T. N., & Kocheril, A. G. (2011) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2011.03276.x · Cited by 74
Preoperative heart rate variability in relation to surgery outcome in refractory epilepsy
Persson, H., Kumlien, E., Ericson, M. O., & Tomson, T. (2005) · Neurology · doi:10.1212/01.wnl.0000181368.50750.1c · Cited by 76
The insular cortex and cardiac response to stroke
Cheshire, W. P., & Saper, C. B. (2006) · Neurology · doi:10.1212/01.wnl.0000219563.87204.7d · Cited by 74
Sympathetic activation in heart failure
Gronda, E., Dusi, V., D’Elia, E., Iacoviello, M., Benvenuto, E., & Vanoli, E. (2022) · European Heart Journal Supplements · doi:10.1093/eurheartjsupp/suac030 · Cited by 73
Autonomic asymmetry in migraine: augmented parasympathetic activation in left unilateral migraineurs
Avnon, Y. (2004) · Brain · doi:10.1093/brain/awh236 · Cited by 73
Functional Abnormalities in Brain Areas That Mediate Autonomic Nervous System Control in Advanced Heart Failure
Woo, M. A., Macey, P. M., Keens, P. T., Kumar, R., Fonarow, G. C., Hamilton, M. A., & Harper, R. M. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2005.02.003 · Cited by 73
Taste as a factor in the management of nutrition
Scott, T. R., & Verhagen, J. V. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00423-8 · Cited by 73
Functional Imaging of Autonomic Regulation: Methods and Key Findings
Macey, P. M., Ogren, J. A., Kumar, R., & Harper, R. M. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00513 · Cited by 81
Control of bladder sensations: An fMRI study of brain activity and effective connectivity
Kuhtz-Buschbeck, J. P., Gilster, R., van der Horst, C., Hamann, M., Wolff, S., & Jansen, O. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.020 · Cited by 70
High‐grade Atrioventricular Block Triggered by Spontaneous and Stimulation‐induced Epileptic Activity in the Left Temporal Lobe
Altenmüller, D., Zehender, M., & Schulze‐Bonhage, A. (2004) · Epilepsia · doi:10.1111/j.0013-9580.2004.34403.x · Cited by 72
Cortical Structures Associated With Human Blood Pressure Control
Lacuey, N., Hampson, J. P., Theeranaew, W., Zonjy, B., Vithala, A., Hupp, N. J., Loparo, K. A., Miller, J. P., & Lhatoo, S. D. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.3344 · Cited by 72
Brain activity in mindfulness depends on experience: a meta-analysis of fMRI studies
Falcone, G., & Jerram, M. (2018) · Mindfulness · doi:10.1007/s12671-018-0884-5 · Cited by 71
Reciprocal Imitation: Toward a Neural Basis of Social Interaction
Guionnet, S., Nadel, J., Bertasi, E., Sperduti, M., Delaveau, P., & Fossati, P. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr177 · Cited by 71
Insular Involvement Is Associated with QT Prolongation: ECG Abnormalities in Patients with Acute Stroke
Tatschl, C., Stöllberger, C., Matz, K., Yilmaz, N., Eckhardt, R., Nowotny, M., Dachenhausen, A., & Brainin, M. (2005) · Cerebrovascular Diseases · doi:10.1159/000089594 · Cited by 71
Cardiac Troponin T Elevation After Stroke: Relationships Between Elevated Serum Troponin T, Stroke Location, and Prognosis
Song, H.-S., Back, J.-H., Jin, D.-K., Chung, P., Moon, H., Suh, B.-C., Kim, Y.-B., Kim, B. M., Woo, H. Y., Lee, Y. T., et al. (2008) · Journal of Clinical Neurology · doi:10.3988/jcn.2008.4.2.75 · Cited by 70
The Critical Role of the Central Autonomic Nervous System in Fetal-Neonatal Transition
Mulkey, S. B., & du Plessis, A. (2018) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2018.05.004 · Cited by 70
Functional imaging of stress urinary incontinence
Herms, A. M. R. D. G., Veit, R., Reisenauer, C., Herms, A. M. R. D. G., Grodd, W., Enck, P., Stenzl, A., & Birbaumer, N. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.018 · Cited by 69
Seizures and syncope:
Britton, J. W., & Benarroch, E. E. (2006) · Clinical Autonomic Research · doi:10.1007/s10286-006-0277-z · Cited by 70
Neural activity related to cognitive and emotional empathy in post-traumatic stress disorder
Mazza, M., Tempesta, D., Pino, M. C., Nigri, A., Catalucci, A., Guadagni, V., Gallucci, M., Iaria, G., & Ferrara, M. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.12.049 · Cited by 69
Noninvasive neuromodulation of subregions of the human insula differentially affect pain processing and heart-rate variability: a within-subjects pseudo-randomized trial
Legon, W., Strohman, A., In, A., Stebbins, K., & Payne, B. (2024) · Pain · doi:10.1097/j.pain.0000000000003171 · Cited by 77
Electrocardiographic abnormalities in acute cerebrovascular events in patients with/without cardiovascular disease
Ashraf, H., Togha, M., Sharifpour, A., Moghadam, M., & Sahraian, M. A. (2013) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.107710 · Cited by 69
Changes in Cerebral Blood Flow during Steady-State Cycling Exercise: A Study Using Oxygen-15-Labeled Water with PET
Hiura, M., Nariai, T., Ishii, K., Sakata, M., Oda, K., Toyohara, J., & Ishiwata, K. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.220 · Cited by 68
Brain Areas Controlling Heart Rate Variability in Tinnitus and Tinnitus-Related Distress
Vanneste, S., & Ridder, D. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059728 · Cited by 68
Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait
Kann, S. J., Zhang, S., Manza, P., Leung, H., & Li, C. R. (2016) · Brain Connectivity · doi:10.1089/brain.2016.0443 · Cited by 69
The neurosteroids allopregnanolone and dehydroepiandrosterone modulate resting-state amygdala connectivity: Neurosteroids Modulate Amygdala Resting fcMRI
Sripada, R. K., Welsh, R. C., Marx, C. E., & Liberzon, I. (2014) · Human Brain Mapping · doi:10.1002/hbm.22399 · Cited by 66
Left-insular damage, autonomic instability, and sudden unexpected death in epilepsy
Lacuey, N., Zonjy, B., Theeranaew, W., Loparo, K. A., Tatsuoka, C., Sahadevan, J., & Lhatoo, S. D. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2015.12.009 · Cited by 66
Pre-ictal heart rate changes: A systematic review and meta-analysis
Bruno, E., Biondi, A., & Richardson, M. P. (2018) · Seizure · doi:10.1016/j.seizure.2018.01.003 · Cited by 66
Neurocardiogenic injury in subarachnoid hemorrhage: A wide spectrum of catecholamin-mediated brain-heart interactions
Wybraniec, M. T., Mizia‐Stec, K., & Krzych, Ł. J. (2014) · Cardiology Journal · doi:10.5603/cj.a2014.0019 · Cited by 65
Dexmedetomidine for the treatment of paroxysmal autonomic instability with dystonia
Goddeau, R., Silverman, S. B., & Sims, J. R. (2007) · Neurocritical Care · doi:10.1007/s12028-007-0066-0 · Cited by 65
Sleep-disordered breathing: Effects on brain structure and function
Harper, R. M., Kumar, R., Ogren, J. A., & Macey, P. M. (2013) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2013.04.021 · Cited by 64

Authors: Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C.
Affiliations: Johns Hopkins University (US)
ORCID: Gelb, Adrian
Hachinski, Vladimir C.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1992-09
Volume: 42
Issue: 9
Pages: 1727-1727
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.42.9.1727
OpenAlex: W2169985903
Cited by: 1,272
References: 22
Citations by year: 2026: 40 · 2025: 31 · 2024: 38 · 2023: 39 · 2022: 47 · 2021: 48 · 2020: 49 · 2019: 64 · 2018: 62 · 2017: 59 · 2016: 63 · 2015: 57 · 2014: 59 · 2013: 50 · 2012: 48
FWCI: 6.24
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
Keywords: insula, cardiovascular effects, electrical brain stimulation, bradycardia, tachycardia, hemispheric lateralization, epilepsy, sudden unexpected death in epilepsy
MeSH terms: Adolescent, Adult, Analysis of Variance, Blood Pressure, Cardiovascular Physiological Phenomena, Cerebral Cortex, Craniotomy, Epilepsy, Heart Rate, Humans, Male, Chi-Square Distribution

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cardiovascular effects of human insular cortex stimulation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks