Cardiovascular effects of human insular cortex stimulation

The Cerebral Cortex of Man: A Clinical Study of Localization of Function

(1968) · JAMA · doi:10.1001/jama.1968.03150020096041 · Cited by 1,218

Insula of the old world monkey. III: Efferent cortical output and comments on function

Mesulam, M. ‐., & Mufson, E. J. (1982) · Journal of Comparative Neurology · doi:10.1002/cne.902120104 · Cited by 1,013

Insula of the old world monkey. Architectonics in the insulo‐orbito‐temporal component of the paralimbic brain

Mesulam, M. M., & Mufson, E. J. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902120102 · Cited by 660

Somato-motor, autonomic and electrocorticographic responses to electrical stimulation of rhinencephalic and other structures in primates, cat, and dog; a study of responses from the limbic, subcallosal, orbito-insular, piriform and temporal cortex, hippocampus-fornix and amygdala.

Kaada, B. R. (1951) · PubMed · Cited by 549

Early mortality following stroke: a prospective review.

Silver, F. L., Norris, J. W., Lewis, A., & Hachinski, V. C. (1984) · Stroke · doi:10.1161/01.str.15.3.492 · Cited by 485

Autonomic responses and efferent pathways from the insular cortex in the rat

Yasui, Y., Breder, C. D., Safer, C. B., & Cechetto, D. F. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903030303 · Cited by 480

Basis for Recurring Ventricular Fibrillation in the Absence of Coronary Heart Disease and Its Management

Lown, B., Temte, J. V., Reich, P., Gaughan, C. E., Regestein, Q. R., & Hai, H. A. (1976) · New England Journal of Medicine · doi:10.1056/nejm197603182941201 · Cited by 374

Cerebrogenic Cardiac Arrhythmias

Oppenheimer, S. M. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530050029008 · Cited by 325

Insular cortex stimulation produces lethal cardiac arrhythmias: a mechanism of sudden death?

Oppenheimer, S. M., Wilson, J. X., Guiraudon, C., & Cechetto, D. F. (1991) · Brain Research · doi:10.1016/0006-8993(91)90412-o · Cited by 298

Cardiac chronotropic organization of the rat insular cortex

Oppenheimer, S. M., & Cechetto, D. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91796-j · Cited by 270

Areas of brain activation in males and females during viewing of erotic film excerpts

Karama, S., Lecours, A., Leroux, J., Bourgouin, P. M., Beaudoin, G., Joubert, S., & Beauregard, M. (2002) · Human Brain Mapping · doi:10.1002/hbm.10014.abs · Cited by 22

Afterload reduction after non-invasive vagus nerve stimulation in acute heart failure

Nagai, M., Dote, K., Kato, M., Sasaki, S., Oda, N., & Förster, C. Y. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1149449 · Cited by 21

Brain metabolites in autonomic regulatory insular sites in heart failure

Woo, M. A., Yadav, S. K., Macey, P. M., Fonarow, G. C., Harper, R. M., & Kumar, R. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.09.006 · Cited by 20

The effects of constrained left versus right monocular viewing on the autonomic nervous system

Burtis, D. B., Heilman, K. M., Mo, J., Wang, C., Lewis, G. F., Davila, M. I., Ding, M., Porges, S. W., & Williamson, J. B. (2014) · Biological Psychology · doi:10.1016/j.biopsycho.2014.05.006 · Cited by 21

Sex Differences in Insular Cortex Gyri Responses to the Valsalva Maneuver

Macey, P. M., Rieken, N. S., Kumar, R., Ogren, J. A., Middlekauff, H. R., Wu, P., Woo, M. A., & Harper, R. M. (2016) · Frontiers in Neurology · doi:10.3389/fneur.2016.00087 · Cited by 20

Obstructive Sleep Apnoea and Hypertension: the Role of the Central Nervous System

Henderson, L. A., & Macefield, V. G. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0665-2 · Cited by 21

Evidence that remodeling of insular cortex neurovascular unit contributes to hypertension‐related sympathoexcitation

Marins, F. R., Iddings, J. A., Fontes, M. A. P., & Filosa, J. A. (2017) · Physiological Reports · doi:10.14814/phy2.13156 · Cited by 22

The human cortical autonomic network and volitional exercise in health and disease.

Al-Khazraji, B., & Shoemaker, J. (2018) · Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · doi:10.1139/apnm-2018-0305 · Cited by 18

Sympathetic Nervous System Activity in Preschoolers Who Stutter

Walsh, B. M., Smith, A., Christ, S. L., & Weber, C. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00356 · Cited by 21

Heart rate analysis differentiates dialeptic complex partial temporal lobe seizures from auras and non-epileptic seizures

de Oliveira, G. R., Gondim, F. D. A. A., Hogan, R. E., & Rola, F. H. (2007) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2007000400003 · Cited by 21

Regional Cerebral Blood Flow During Temporal Lobe Seizures Associated with Ictal Vomiting: An Ictal SPECT Study in Two Patients

Baumgartner, C., Olbrich, A., Lindinger, G., Pataraia, E., Gröppel, G., Bacher, J., Aull, S., Serles, W., Hoffmann, M., Leutmezer, F., et al. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb00823.x · Cited by 21

Selectively diminished corpus callosum fibers in congenital central hypoventilation syndrome

Kumar, R., Macey, P. M., Woo, M. A., & Harper, R. M. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.01.021 · Cited by 20

Neurohumoral Cardiac Regulation: Optogenetics Gets Into the Groove

Scalco, A., Moro, N., Mongillo, M., & Zaglia, T. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.726895 · Cited by 23

The role of central autonomic nervous system dysfunction in Takotsubo syndrome: a systematic review

Brázdil, V., Kala, P., Hudec, M., Poloczek, M., Kaňovský, J., Štípal, R., Jeřábek, P., Boček, O., Pail, M., & Brázdil, M. (2022) · Clinical Autonomic Research · doi:10.1007/s10286-021-00844-z · Cited by 21

Denervation or stimulation? Role of sympatho-vagal imbalance in HFpEF with hypertension

Nagai, M., Dote, K., & Förster, C. Y. (2023) · Hypertension Research · doi:10.1038/s41440-023-01272-4 · Cited by 21

Altered amygdala volumes and microstructure in focal epilepsy patients with tonic–clonic seizures, ictal, and post‐convulsive central apnea

Zeicu, C., Legouhy, A., Scott, C. A., Oliveira, J. F. A., Winston, G. P., Duncan, J. S., Vos, S. B., Thom, M., Lhatoo, S. D., Zhang, H. G., et al. (2023) · Epilepsia · doi:10.1111/epi.17804 · Cited by 20

ECG monitoring of post-stroke occurring arrhythmias: an observational study using 7-day Holter ECG

Carrarini, C., Stefano, V. D., Russo, M., Dono, F., Pietro, M. D., Furia, N., ONOFRJ, M. C., Bonanni, L., Faustino, M., & Angelis, M. V. D. (2022) · Scientific Reports · doi:10.1038/s41598-021-04285-6 · Cited by 20

An investigation into asymmetrical cortical regulation of salivary S-IgA in conscious man using transcranial magnetic stimulation

Clow, A., Lambert, S., Evans, P., Hucklebridge, F. H., & Higuchi, K. (2003) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(02)00093-4 · Cited by 20

Ictal asystole—Late manifestation of partial epilepsy and importance of cardiac pacemaker

Zubair, S., Arshad, A. B., Saeed, B., Luqman, S., & Oommen, K. J. (2009) · Seizure · doi:10.1016/j.seizure.2009.03.004 · Cited by 20

Quantitative electroencephalographic analyses of cardiovascular regulation in low- and high-hostile men

Demaree, H. A., Harrison, D. W., & Rhodes, R. D. (2000) · Psychobiology · doi:10.3758/bf03332000 · Cited by 20

Acute and Short-Term Autonomic and Hemodynamic Responses to Transcranial Direct Current Stimulation in Patients With Resistant Hypertension

Rodrigues, B., Barboza, C. D. A., Moura, E. G., Ministro, G., Ferreira‐Melo, S. E., Castaño, J. B., Nunes, W. M. S., Mostarda, C. T., Coca, A., Vianna, L. C., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.853427 · Cited by 19

Site and size of multiple sclerosis lesions predict enhanced or decreased female orgasmic function

Winder, K., Seifert, F., Koehn, J., Deutsch, M., Engelhorn, T., Dörfler, A., Lee, D.-H., Linker, R., & Hilz, M. (2015) · Journal of Neurology · doi:10.1007/s00415-015-7907-0 · Cited by 20

Right insular infarction and mortality after ischaemic stroke

Hanne, L., Brunecker, P., Grittner, U., Endres, M., Villringer, K., Fiebach, J. B., & Ebinger, M. (2016) · European Journal of Neurology · doi:10.1111/ene.13131 · Cited by 19

Role of the insula in top–down processing: an intracranial EEG study using a visual oddball detection paradigm

Citherlet, D., Boucher, O., Tremblay, J., Robert, M., Gallagher, A., Bouthillier, A., Leporé, F., & Nguyen, D. K. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01892-y · Cited by 19

Identification of brain region for coordinating speech articulation

Donnan, G. A., Darby, D., & Saling, M. M. (1997) · The Lancet · doi:10.1016/s0140-6736(05)64855-6 · Cited by 19

MRI-Based Definition of a Stereotactic Two-Dimensional Template of the Human Insula

Afif, A., Hoffmann, D., Becq, G., Guénot, M., Magnin, M., & Mertens, P. (2009) · Stereotactic and Functional Neurosurgery · doi:10.1159/000258079 · Cited by 19

Cardiac Arrhythmias and Ictal Events Within an Epilepsy Monitoring Unit

Standridge, S. M., Holland, K. D., & Horn, P. S. (2010) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2009.10.010 · Cited by 19

Altered cortical activation patterns associated with baroreflex unloading following 24 h of physical deconditioning

Shoemaker, J. K., Usselman, C. W., Rothwell, A., & Wong, W. S. (2012) · Experimental Physiology · doi:10.1113/expphysiol.2012.065557 · Cited by 18

Abnormal repolarization: A common electrocardiographic finding in patients with epilepsy

Hayashi, K., Kohno, R., Akamatsu, N., Benditt, D. G., & Abe, H. (2018) · Journal of Cardiovascular Electrophysiology · doi:10.1111/jce.13746 · Cited by 19

Monitoring heart period variability changes during seizures. II. Diversity and trends

Vaughn, B. V., Quint, S. R., Tennison, M. B., & Messenheimer, J. A. (1996) · Journal of Epilepsy · doi:10.1016/0896-6974(95)00061-5 · Cited by 19

Supression of cardiac parasympathetic functions in patients with right hemispheric stroke

Erciyas, A. H., Topalkara, K., Topaktas, S. A., Akyüz, A., & Dener, Ş. (1999) · European Journal of Neurology · doi:10.1046/j.1468-1331.1999.660685.x · Cited by 19

The Role of the Autonomic Nervous System in Epilepsy and Migraine: A Narrative Review

D’Agnano, D., Cernigliaro, F., Ferretti, A., Cascio, S. L., Correnti, E., Terrin, G., Santangelo, A., Bellone, G., Raieli, V., Sciruicchio, V., et al. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2307128 · Cited by 18

Early atypical signs and insula hypometabolism predict survival in multiple system atrophy

Grimaldi, S., Boucékine, M., Witjas, T., Fluchère, F., Azulay, J., Guedj, É., & Eusébio, A. (2021) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-324823 · Cited by 18

Cardiovascular autonomic function and baroreflex sensitivity in drug-resistant temporal lobe epilepsy

Athira, S. B., Pal, P., Nair, P. P., Nanda, N., & Aghoram, R. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2022.109013 · Cited by 18

Insular Role in Blood Pressure and Systemic Vascular Resistance Regulation

Sánchez‐Larsen, Á., Príncipe, A., Ley, M., Vaquerizo, B., Langohr, K., & Rocamora, R. (2023) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2022.12.012 · Cited by 18

A common neural code for representing imagined and inferred tastes

Avery, J. A., Carrington, M., & Martin, A. D. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2023.102423 · Cited by 19

Central stress pathways in the development of cardiovascular disease

Braun, J., Patel, M., Kameneva, T., Keatch, C., Lambert, G. W., & Lambert, É. (2023) · Clinical Autonomic Research · doi:10.1007/s10286-023-01008-x · Cited by 19

Incidence and Types of Cardiac Arrhythmias in the Peri-Ictal Period in Patients Having a Generalized Convulsive Seizure

Vilella, L., Miyake, C. Y., Chaitanya, G., Hampson, J. P., Omidi, S. J., Ochoa‐Urrea, M., Talavera, B., Páez, O. M., Hupp, N. J., Hampson, J. S., et al. (2024) · Neurology · doi:10.1212/wnl.0000000000209501 · Cited by 18

Rightward dominance in temporal high‐frequency electrical asymmetry corresponds to higher resting heart rate and lower baroreflex sensitivity in a heterogeneous population

Tegeler, C. H., Shaltout, H. A., Tegeler, C. L., Gerdes, L., & Lee, S. W. (2015) · Brain and Behavior · doi:10.1002/brb3.343 · Cited by 18

Electrical stimulation of the insulo-opercular region: visual phenomena and altered body-ownership symptoms

Yu, K., Yu, T., Qiao, L., Liu, C., Wang, X., Zhou, X., Ni, D., Zhang, G., & Li, Y. (2018) · Epilepsy Research · doi:10.1016/j.eplepsyres.2018.09.014 · Cited by 22

Heart rate variability and vagus nerve stimulation in epilepsy patients

Constantinescu, V. A., Matei, D. V., Constantinescu, I., & Cuciureanu, D. I. (2019) · Translational Neuroscience · doi:10.1515/tnsci-2019-0036 · Cited by 18

Sex Hormone-Specific Neuroanatomy of Takotsubo Syndrome: Is the Insular Cortex a Moderator?

Nagai, M., Förster, C. Y., & Dote, K. (2022) · Biomolecules · doi:10.3390/biom12010110 · Cited by 18

Do subclinical electrographic seizure patterns affect heart rate and its variability?

Adjei, P., Surges, R., Scott, C. A., Kallis, C., Shorvon, S. D., & Walker, M. C. (2009) · Epilepsy Research · doi:10.1016/j.eplepsyres.2009.08.011 · Cited by 18

Effects of regional brain injury on the newborn autonomic nervous system

Sender, N. S., Govindan, R. B., Sulemanji, M., Al‐Shargabi, T., Lenin, R. B., Ekşioğlu, Y. Z., & du Plessis, A. J. (2014) · Early Human Development · doi:10.1016/j.earlhumdev.2014.10.003 · Cited by 18

Hyperventilation induces sympathetic overactivation in mesial temporal epilepsy

Assenza, G., Mecarelli, O., Tombini, M., Pulitano, P., Pellegrino, G., Benvenga, A., Assenza, F., Campana, C., Pino, G. D., & Lazzaro, V. D. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.12.003 · Cited by 18

Lateralized Resting-State Functional Brain Network Organization Changes in Heart Failure

Park, B., Roy, B., Woo, M. A., Palomares, J. A., Fonarow, G. C., Harper, R. M., & Kumar, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0155894 · Cited by 18

Fear processing is differentially affected by lateralized stimulation of carotid baroreceptors

Makovac, E., Garfinkel, S. N., Bassi, A., Basile, B., Macaluso, E., Cercignani, M., Calcagnini, G., Mattei, E., Mancini, M., Agalliu, D., et al. (2017) · Cortex · doi:10.1016/j.cortex.2017.07.002 · Cited by 18

Cerebral arrhythmia influencing cardiac rhythm: A case of ictal bradycardia

Almansori, M., Ijaz, M., & Ahmed, S. N. (2006) · Seizure · doi:10.1016/j.seizure.2006.05.008 · Cited by 18

The brain–heart axis: effects of cardiovascular disease on the CNS and opportunities for central neuromodulation

van Weperen, V. Y. H., & Vaseghi, M. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-01000-6 · Cited by 25

Cardiac autonomic dynamics during sleep are lost in patients with TIA and stroke

Tobaldini, E., Proserpio, P., Oppo, V., Figorilli, M., Fiorelli, E. M., Manconi, M., Agostoni, E. C., Nobili, L., Montano, N., Horvath, T., et al. (2019) · Journal of Sleep Research · doi:10.1111/jsr.12878 · Cited by 17

Structural Gray and White Matter Differences in Patients With Type 1 Diabetes and Impaired Awareness of Hypoglycemia

Stantonyonge, N., Sampedro, F., Méndez, J., Martínez‐Horta, S., Chico, A. I., & Gómez‐Ansón, B. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa832 · Cited by 16

Role of autonomic system imbalance in neurogenic pulmonary oedema

Yang, A., Liu, B., & Inoue, T. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15648 · Cited by 17

A new perspective on HIV: effects of HIV on brain-heart axis

Shao, H., & Li, S. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1226782 · Cited by 17

Sex differences in insular cortex gyri responses to a brief static handgrip challenge

Macey, P. M., Rieken, N. S., Ogren, J. A., Macey, K. E., Kumar, R., & Harper, R. M. (2017) · Biology of Sex Differences · doi:10.1186/s13293-017-0135-9 · Cited by 17

Cerebrovascular blood oxygenation level dependent pulsatility at baseline and following acute exercise among healthy adolescents

Theyers, A. E., Goldstein, B. I., Metcalfe, A. W. S., Robertson, A. D., & MacIntosh, B. J. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18766771 · Cited by 17

Spatiotemporal dynamics of auditory information processing in the insular cortex: an intracranial EEG study using an oddball paradigm

Citherlet, D., Boucher, O., Tremblay, J., Robert, M., Gallagher, A., Bouthillier, A., Leporé, F., & Nguyen, D. K. (2020) · Brain Structure and Function · doi:10.1007/s00429-020-02072-z · Cited by 17

Effect of Triple Combination Therapy With Lopinavir-Ritonavir, Azithromycin, and Hydroxychloroquine on QT Interval and Arrhythmic Risk in Hospitalized COVID-19 Patients

Russo, V., Carbone, A., Mottola, F. F., Mocerino, R., Verde, R., Attena, E., Verde, N., Micco, P. D., Nunziata, L., Santelli, F., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.582348 · Cited by 17

Neural and physiological responses to a cold pressor challenge in healthy adolescents

Richardson, H. L., Macey, P. M., Kumar, R., Valladares, E. M., Woo, M. A., & Harper, R. M. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23283 · Cited by 17

The relationship between seizure onset zone and ictal tachycardia: An intracranial EEG study

Stefanidou, M., Carlson, C., & Friedman, D. J. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.01.020 · Cited by 17

Severe Bradycardia During Epilepsy Surgery

Sato, K., Shamoto, H., & Yoshimoto, T. (2001) · Journal of Neurosurgical Anesthesiology · doi:10.1097/00008506-200110000-00009 · Cited by 17

HEART RATE AND FLUENCY PERFORMANCE AMONG HIGH- AND LOW-ANXIOUS MEN FOLLOWING AUTONOMIC STRESS

Everhart, D. E., & Harrison, D. W. (2002) · International Journal of Neuroscience · doi:10.1080/00207450290026120 · Cited by 17

Increased activity of the temporal insula in subjects with bradycardia

Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Gatley, J. S., Pappas, N. R., Wong, C., & Felder, C. A. (2000) · Life Sciences · doi:10.1016/s0024-3205(00)00807-9 · Cited by 17

Sinus node arrest secondary to HSV encephalitis

Smith, B. K., Cook, M. J., & Prior, D. (2007) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2006.06.017 · Cited by 17

Are Decreases in Insular Regional Cerebral Blood Flow Sustained during Postexercise Hypotension?

WILLIAMSON, J. W., QUERRY, R. G., McColl, R. W., & Mathews, D. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31818b98c8 · Cited by 17

Sympathetic Neural Control in Humans with Anxiety‐Related Disorders

Bigalke, J. A., & Carter, J. R. (2021) · Comprehensive physiology · doi:10.1002/cphy.c210027 · Cited by 29

Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variabilityPreprint

Legon, W., Strohman, A., In, A., Stebbins, K., & Payne, B. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.05.539593 · Cited by 17

Incidence and Outcomes of Patients With Early Cardiac Complications After Intracerebral Hemorrhage: A Report From VISTA

Ishiguchi, H., Huang, B., El‐Bouri, W. K., Dawson, J., Lip, G. Y. H., Abdul‐Rahim, A. H., Lees, K. R., Alexandrov, A. V., Bath, P. M., Bluhmki, E., et al. (2024) · Stroke · doi:10.1161/strokeaha.124.048189 · Cited by 16

Lateralized deficits in arousal processing after insula lesions: Behavioral and autonomic evidence

Holtmann, O., Franz, M., Mönig, C., Tenberge, J., Schloßmacher, I., Ivanova, I., Preul, C., Schwindt, W., Melzer, N., Miltner, W. H. R., et al. (2022) · Cortex · doi:10.1016/j.cortex.2021.12.013 · Cited by 18

Epilepsy and Takotsubo Cardiomyopathy: A Case Report

Naganuma, M., Isoda, K., Ishizaki, M., Ito, K., Hirano, T., & Uchino, M. (2011) · Internal Medicine · doi:10.2169/internalmedicine.50.5705 · Cited by 16

Differences in Insula and Pre-/Frontal Responses during Reappraisal of Food in Lean and Obese Humans

Kumar, S., Grundeis, F., Brand, C., Hwang, H., Mehnert, J., & Pleger, B. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00233 · Cited by 16

Ictal bradyarrhythmias and asystole requiring pacemaker implantation: Combined EEG–ECG analysis of 5 cases

Bartlam, R., & Mohanraj, R. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.06.026 · Cited by 16

Pathophysiology and Risk of Atrial Fibrillation Detected after Ischemic Stroke (PARADISE): A Translational, Integrated, and Transdisciplinary Approach

Paquet, M., Cerasuolo, J. O., Thorburn, V., Fridman, S., Alsubaie, R., Lópes, R. D., Cipriano, L. E., Salamone, P., Melling, C. W. J., KHAN, A. R., et al. (2017) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.09.038 · Cited by 16

Danhong Injection Reversed Cardiac Abnormality in Brain–Heart Syndrome via Local and Remote β-Adrenergic Receptor Signaling

Orgah, J. O., Yu, J., Zhao, T., Wang, L., Yang, M., Zhang, Y., Fan, G., & Zhu, Y. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00692 · Cited by 16

Fat perception in the human frontal operculum, insular and somatosensory cortex

Wistehube, T., Rullmann, M., Wiacek, C., Braun, P., & Pleger, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-30366-0 · Cited by 16

Altered Relationship Between Heart Rate Variability and fMRI-Based Functional Connectivity in People With Epilepsy

Kassinopoulos, M., Harper, R. M., Guye, M., Lemieux, L., & Diehl, B. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.671890 · Cited by 19

New insights on the role of the insular cortex and habenula in OSA

Li, M., Yan, C., & Shao, W. (2015) · Sleep And Breathing · doi:10.1007/s11325-015-1168-0 · Cited by 15

The Brain‐Heart Connection: Frontal Cortex and Left Ventricle Angiotensinase Activities in Control and Captopril‐Treated Hypertensive Rats—A Bilateral Study

Segarra, A. B., Prieto, I., Banegas, I., Villarejo, A. B., Wangensteen, R., de Gasparo, M., Vives, F., & Ramírez‐Sánchez, M. (2013) · International Journal of Hypertension · doi:10.1155/2013/156179 · Cited by 16

Visceral sensitization in postural tachycardia syndrome

Khurana, R. K. (2014) · Clinical Autonomic Research · doi:10.1007/s10286-014-0227-0 · Cited by 16

Mood disturbances and cognitive functioning in Parkinson's disease: The effects of disease duration and side of onset of motor symptoms

Foster, P. S., Drago, V., Mendez, K., Witt, J. C., Crucian, G. P., & Heilman, K. M. (2013) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2012.753037 · Cited by 16

Initial Troponin Level as a Predictor of Prognosis in Patients with Intracerebral Hemorrhage

Chung, P., Won, Y. S., Kwon, Y. J., Choi, C. S., & Kim, B. M. (2009) · Journal of Korean Neurosurgical Society · doi:10.3340/jkns.2009.45.6.355 · Cited by 16

Takotsubo Cardiomyopathy and Neurogenic Pulmonary Edema After Carotid Endarterectomy

Kitagawa, T., Ishikawa, H., Yamamoto, J., & Ota, S. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2018.12.206 · Cited by 16

Sudden cardiac death

Rabinstein, A. A. (2013) · Handbook of clinical neurology · doi:10.1016/b978-0-7020-4086-3.00002-3 · Cited by 16

The Action Sites of Propofol in the Normal Human Brain Revealed by Functional Magnetic Resonance Imaging

Zhang, H., Wang, W., Zhao, Z., Ge, Y., Zhang, J., Dai-hua, Y., Chai, W., Wu, S., & Xu, L. (2010) · The Anatomical Record · doi:10.1002/ar.21289 · Cited by 16

Exercise-Induced Decrease in Insular Cortex rCBF during Postexercise Hypotension

LAMB, K., GALLAGHER, K., McColl, R. W., Mathews, D., QUERRY, R. G., & WILLIAMSON, J. W. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31802f04e0 · Cited by 16

Brain Tumour as a Rare Cause of Cardiac Syncope

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Insular Cortex Hypoperfusion and Acute Phase Blood Glucose After Stroke

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Heart rate variability in neonatal seizures: Investigation and implications for management

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A century of exercise physiology: key concepts in neural control of the circulation

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Investigating the effect of mindfulness training for stress management in military training: the relationship between the autonomic nervous system and emotional regulation

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Acute, localised paroxysmal pain as the initial manifestation of focal seizures: A case report and a brief review of the literature

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Decreased Cortical Thickness in Central Hypoventilation Syndrome

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What Impact does An Angry Context have Upon Us? The Effect of Anger on Functional Connectivity of the Right Insula and Superior Temporal Gyri

Mazzola, V., Arciero, G., Fazio, L., Lanciano, T., Gelao, B., Popolizio, T., Vuilleumier, P. O., Bondolfi, G., & Bertolino, A. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00109 · Cited by 15

Asystole Induced by Partial Seizures:

Carinci, V., BARBATO, G., Baldrati, A., & Pasquale, G. D. (2007) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2007.00883.x · Cited by 15

Neural circuits of disgust induced by sexual stimuli in homosexual and heterosexual men: An fMRI study

Zhang, M., Hu, S., Xu, L., Wang, Q., Xu, X., Wei, E.-Q., Yan, L., Hu, J., Wei, N., Zhou, W., et al. (2010) · European Journal of Radiology · doi:10.1016/j.ejrad.2010.05.021 · Cited by 15

Novel Aspects on Epilepsy

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A Preliminary Study of the Effectiveness of an Allostatic, Closed-Loop, Acoustic Stimulation Neurotechnology in the Treatment of Athletes with Persisting Post-concussion Symptoms

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Emotion and the Autonomic Nervous System—A Two-Way Street: Insights From Affective, Autonomic and Dissociative Disorders

Owens, A. P., Low, D. A., Iodice, V., Mathias, C. J., & Critchley, H. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.01799-5 · Cited by 16

Cardiac Dysfunction in Neurocritical Care: An Autonomic Perspective

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Potential Deep Brain Stimulation Targets for the Management of Refractory Hypertension

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Psychophysiological Correlates of Antisocial Behavior: A Central Control Hypothesis

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How the insula speaks to the heart: Cardiac responses to insular stimulation in humans

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Left-insular cortex lesions perturb cardiac autonomic tone in humans

Oppenheimer, S. M., Kedem, G., & Martin, W. M. (1996) · Clinical Autonomic Research · doi:10.1007/bf02281899 · Cited by 308

Cardiac chronotropic organization of the rat insular cortex

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Mapping the Insular Cortex for Cardiac Responses in Humans (P2-7.001)

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The anatomy and physiology of cortical mechanisms of cardiac control.

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