Dose-response relationship of levodopa with mood and anxiety in fluctuating Parkinson's disease: A double-blind, placebo-controlled study
Abstract
We investigated the effect of levodopa on mood and anxiety in eight Parkinson's disease patients with motor fluctuations. Each patient received 0.0-, 0.5-, and 1.0-mg/kg/hr levodopa infusions in randomly assigned order under double-blind conditions on consecutive days. Mood elevation and anxiety reduction based on half-hourly patient rating and a corresponding increase in tapping speed occurred with active drug infusion but not placebo infusion. The effects were dose related. The higher-dose infusion rate produced more rapid onset, greater magnitude, and longer duration of response. We conclude that mood and anxiety fluctuations related to levodopa dosing are robust pharmacologic, and not placebo, effects.
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Anxiety symptoms experienced by patients with Parkinson's disease are often responsive to dopaminergic medication.
“The anxiety symptoms experienced by patients with PD are often responsive to dopaminergic medication [15].”
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Thobois, S., Ardouin, C., Schmitt, E., Lhommée, E., Klinger, H., Xie, J., Lagrange, C., Kistner, A., Kombo, M. A., Fleury, V., et al. (2010) · Revue Neurologique · doi:10.1016/j.neurol.2010.07.006 · Cited by 28 · see citing works
Sgroi, S., Kaelin‐Lang, A., & Capper-Loup, C. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00331 · Cited by 28 · see citing works
Behavioral disturbances in Parkinson's disease
Anderson, K. E. (2004) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2004.6.3/kanderson · Cited by 27 · see citing works
Clinical risk–benefit assessment of dopamine agonists
Möller, J. C., Eggert, K. M., Unger, M. M., Odin, P., Chaudhuri, К. R., & Oertel, W. H. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02214.x · Cited by 27 · see citing works
Dopamine D1Agonist Activates Temporal Lobe Structures in Primates
BLACK, K. J., Hershey, T. G., Gado, M. H., & Perlmutter, J. S. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.549 · Cited by 24 · see citing works
Phenomenology of Atypical Anxiety Disorders in Parkinson's Disease: A Systematic Review
Dissanayaka, N. N., Forbes, E. J., Perepezko, K. M., Leentjens, A. F. G., Dobkin, R. D., Dujardin, K., & Pontone, G. M. (2022) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2022.02.004 · Cited by 23 · see citing works
The Human Experience with Intravenous Levodopa
Siddiqi, S., Abraham, N., Geiger, C. L., Karimi, M., Perlmutter, J. S., & BLACK, K. J. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00307 · Cited by 22 · see citing works
Depression in alpha-synucleinopathies: prevalence, pathophysiology and treatment
Stefanova, N., Seppi, K., Scherfler, C., Puschban, Z., & Wenning, G. K. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6301-6_23 · Cited by 22 · see citing works
- Authors
- Maricle, R. A., Nutt, J. G., Valentine, R. J., & Carter, J. H.
- Affiliations
- Oregon Health & Science University (US)
- ORCID
- Nutt, John G.
- Venue
- Neurology
- Published
- 1995-09
- Volume
- 45
- Issue
- 9
- Pages
- 1757-1760
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2107507666
- Cited by
- 197
- References
- 5
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 16 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 11 · 2012: 6
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS021062)
- National Center for Research Resources (RR-00334, M01RR000334)
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- levodopa, Parkinson's disease, motor fluctuations, mood improvement, anxiety, levodopa infusion, placebo effect, tapping speed
- MeSH terms
- Affect, Aged, Anxiety, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Levodopa, Male, Middle Aged, Parkinson Disease
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