Cited by 197Parkinson's Disease Mechanisms and TreatmentsNeurological disorders and treatmentsNeurotransmitter Receptor Influence on Behavior

Dose-response relationship of levodopa with mood and anxiety in fluctuating Parkinson's disease: A double-blind, placebo-controlled study

Maricle, Robert A., Nutt, John G., Valentine, Rita J., Carter, Julie H.·1995·Neurology

Abstract

We investigated the effect of levodopa on mood and anxiety in eight Parkinson's disease patients with motor fluctuations. Each patient received 0.0-, 0.5-, and 1.0-mg/kg/hr levodopa infusions in randomly assigned order under double-blind conditions on consecutive days. Mood elevation and anxiety reduction based on half-hourly patient rating and a corresponding increase in tapping speed occurred with active drug infusion but not placebo infusion. The effects were dose related. The higher-dose infusion rate produced more rapid onset, greater magnitude, and longer duration of response. We conclude that mood and anxiety fluctuations related to levodopa dosing are robust pharmacologic, and not placebo, effects.

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Crossref · 10.1212/wnl.45.9.1757

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Authors
Maricle, R. A., Nutt, J. G., Valentine, R. J., & Carter, J. H.
Affiliations
Oregon Health & Science University (US)
Venue
Neurology
Published
1995-09
Volume
45
Issue
9
Pages
1757-1760
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2107507666
Cited by
197
References
5
Citations by year
2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 16 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 11 · 2012: 6
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Neurological Disorders and Stroke (R01NS021062)
  • National Center for Research Resources (RR-00334, M01RR000334)
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
levodopa, Parkinson's disease, motor fluctuations, mood improvement, anxiety, levodopa infusion, placebo effect, tapping speed
MeSH terms
Affect, Aged, Anxiety, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Levodopa, Male, Middle Aged, Parkinson Disease

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