Clinical and neuropsychological differences between patients with earlier and later onset of Alzheimer's disease: A CERAD analysis, part XII
Abstract
To determine whether the age of the onset of Alzheimer's disease (AD) is related to the expression and rate of decline of this disorder, we examined the clinical and neuropsychological performance of 421 patients entered into the Consortium to Establish a Registry for Alzheimer's Disease and followed annually for up to 4 years. Statistical analyses were based on multivariable logistic regression analysis for dichotomous clinical measures and multivariable linear regression analysis for psychometric measures. All analyses examined the effect of age after controlling for gender, education, and stage of dementia. Clinical information obtained on entry into the study indicated that younger patients performed more poorly on measures of language and concentration, and older patients performed more poorly on measures of memory and orientation. On neuropsychological measures at entry, younger patients, performed more poorly on praxis and had significantly higher scores of confrontation naming. Younger age predicted a significantly faster rate of progression for all neuropsychological measures. These findings support the concept of age-related clinical subtypes of AD.
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Memory function is generally more disrupted in LOAD patients than in EOAD patients.
“memory function is generally more disrupted in LOAD patients (Jacobs et al., 1994; Koss et al., 1996; Smits et al., 2012)”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Koss et al., 1996
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Assessment [RETIRED]: Magnetoencephalography (MEG)
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- Authors
- Koss, E., Edland, S., Fillenbaum, G., Mohs, R., Clark, C., Galasko, D., & Morris, J. C.
- Affiliations
- Case Western Reserve University (US)
- Venue
- Neurology
- Published
- 1996-01
- Volume
- 46
- Issue
- 1
- Pages
- 136-141
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2010827885
- Cited by
- 150
- References
- 1
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 11 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 8
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (U01 AG06790, U01AG006790)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- Alzheimer's disease, age of onset, disease progression, decline rate, neuropsychological performance, clinical subtypes, memory, language, orientation, praxis, confrontation naming, dementia stages, age differences
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Age of Onset
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