Distinct 18F-AV-1451 tau PET retention patterns in early- and late-onset Alzheimer’s disease
Open accessAbstract
Patients with Alzheimer's disease can present with different clinical phenotypes. Individuals with late-onset Alzheimer's disease (>65 years) typically present with medial temporal lobe neurodegeneration and predominantly amnestic symptomatology, while patients with early-onset Alzheimer's disease (<65 years) exhibit greater neocortical involvement associated with a clinical presentation including dyspraxia, executive dysfunction, or visuospatial impairment. We recruited 20 patients with early-onset Alzheimer's disease, 21 with late-onset Alzheimer's disease, three with prodromal early-onset Alzheimer's disease and 13 with prodromal late-onset Alzheimer's disease, as well as 30 cognitively healthy elderly controls, that had undergone 18F-AV-1451 tau positron emission tomography and structural magnetic resonance imaging to explore whether early- and late-onset Alzheimer's disease exhibit differential regional tau pathology and atrophy patterns. Strong associations of lower age at symptom onset with higher 18F-AV-1451 uptake were observed in several neocortical regions, while higher age did not yield positive associations in neither patient group. Comparing patients with early-onset Alzheimer's disease with controls resulted in significantly higher 18F-AV-1451 retention throughout the neocortex, while comparing healthy controls with late-onset Alzheimer's disease patients yielded a distinct pattern of higher 18F-AV-1451 retention, predominantly confined to temporal lobe regions. When compared against each other, the early-onset Alzheimer's disease group exhibited greater uptake than the late-onset group in prefrontal and premotor, as well as in inferior parietal cortex. These preliminary findings indicate that age may constitute an important contributor to Alzheimer's disease heterogeneity highlighting the potential of tau positron emission tomography to capture phenotypic variation across patients with Alzheimer's disease.
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Elevated tau PET binding in medial temporal lobe structures and neocortex is strongly associated with positive amyloid PET scans and with clinical impairment across the normal aging to dementia clinical spectrum.
“Elevated tau PET binding in both medial temporal lobe structures and the neocortex is strongly associated with positive amyloid PET scans and with clinical impairment across the normal aging to dementia clinical spectrum [82,130–141].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [137]
Recent tau PET studies with [18F]flortaucipir showed that EOAD had greater tau burden in the neocortex compared to LOAD patients.
“Recent tau PET studies with [18F]flortaucipir showed that EOAD had greater tau burden in the neocortex compared to LOAD patients (Cho et al., 2017; Schöll et al., 2017).”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Schöll et al., 2017
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Imaging of Tau Pathology in Neurodegenerative Diseases: An Update
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- Authors
- Schöll, M., Ossenkoppele, R., Strandberg, O., Palmqvist, S., study, T. S. B., Jögi, J., Ohlsson, T., Smith, R., & Hansson, O.
- Affiliations
- Lund University (SE)
- Amsterdam Neuroscience (NL)
- Skåne University Hospital (SE)
- Corresponding author
- Schöll, Michael
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-07-16
- Volume
- 140
- Issue
- 9
- Pages
- 2286-2294
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- OpenAlex
- W2751819353
- Cited by
- 180
- References
- 28
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 13 · 2023: 24 · 2022: 17 · 2021: 30 · 2020: 29 · 2019: 23 · 2018: 16 · 2017: 1
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Research Council
- Swedish Research Council
- Swedish Brain Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, early-onset Alzheimer's disease, late-onset Alzheimer's disease, 18F-AV-1451, tau PET, age at symptom onset, prodromal Alzheimer's disease, temporal lobe atrophy, prefrontal cortex, inferior parietal cortex, disease heterogeneity, clinical phenotype
- MeSH terms
- Aged, Aging, Alzheimer Disease, Atrophy, Carbolines, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Case-Control Studies, tau Proteins, Age of Onset, Tauopathies, Positron-Emission Tomography, Neuroimaging, Prodromal Symptoms
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