Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease
Open accessAbstract
The factors driving clinical heterogeneity in Alzheimer's disease are not well understood. This study assessed the relationship between amyloid deposition, glucose metabolism and clinical phenotype in Alzheimer's disease, and investigated how these relate to the involvement of functional networks. The study included 17 patients with early-onset Alzheimer's disease (age at onset <65 years), 12 patients with logopenic variant primary progressive aphasia and 13 patients with posterior cortical atrophy [whole Alzheimer's disease group: age = 61.5 years (standard deviation 6.5 years), 55% male]. Thirty healthy control subjects [age = 70.8 (3.3) years, 47% male] were also included. Subjects underwent positron emission tomography with (11)C-labelled Pittsburgh compound B and (18)F-labelled fluorodeoxyglucose. All patients met National Institute on Ageing-Alzheimer's Association criteria for probable Alzheimer's disease and showed evidence of amyloid deposition on (11)C-labelled Pittsburgh compound B positron emission tomography. We hypothesized that hypometabolism patterns would differ across variants, reflecting involvement of specific functional networks, whereas amyloid patterns would be diffuse and similar across variants. We tested these hypotheses using three complimentary approaches: (i) mass-univariate voxel-wise group comparison of (18)F-labelled fluorodeoxyglucose and (11)C-labelled Pittsburgh compound B; (ii) generation of covariance maps across all subjects with Alzheimer's disease from seed regions of interest specifically atrophied in each variant, and comparison of these maps to functional network templates; and (iii) extraction of (11)C-labelled Pittsburgh compound B and (18)F-labelled fluorodeoxyglucose values from functional network templates. Alzheimer's disease clinical groups showed syndrome-specific (18)F-labelled fluorodeoxyglucose patterns, with greater parieto-occipital involvement in posterior cortical atrophy, and asymmetric involvement of left temporoparietal regions in logopenic variant primary progressive aphasia. In contrast, all Alzheimer's disease variants showed diffuse patterns of (11)C-labelled Pittsburgh compound B binding, with posterior cortical atrophy additionally showing elevated uptake in occipital cortex compared with early-onset Alzheimer's disease. The seed region of interest covariance analysis revealed distinct (18)F-labelled fluorodeoxyglucose correlation patterns that greatly overlapped with the right executive-control network for the early-onset Alzheimer's disease region of interest, the left language network for the logopenic variant primary progressive aphasia region of interest, and the higher visual network for the posterior cortical atrophy region of interest. In contrast, (11)C-labelled Pittsburgh compound B covariance maps for each region of interest were diffuse. Finally, (18)F-labelled fluorodeoxyglucose was similarly reduced in all Alzheimer's disease variants in the dorsal and left ventral default mode network, whereas significant differences were found in the right ventral default mode, right executive-control (both lower in early-onset Alzheimer's disease and posterior cortical atrophy than logopenic variant primary progressive aphasia) and higher-order visual network (lower in posterior cortical atrophy than in early-onset Alzheimer's disease and logopenic variant primary progressive aphasia), with a trend towards lower (18)F-labelled fluorodeoxyglucose also found in the left language network in logopenic variant primary progressive aphasia. There were no differences in (11)C-labelled Pittsburgh compound B binding between syndromes in any of the networks. Our data suggest that Alzheimer's disease syndromes are associated with degeneration of specific functional networks, and that fibrillar amyloid-β deposition explains at most a small amount of the clinico-anatomic heterogeneity in Alzheimer's disease.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Discordance between imaging biomarkers has been noted in sporadic AD.
“Discordance between imaging biomarkers has been noted in sporadic AD 37–44.”
From Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study (2018) · cites this paper as [41]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., Klunk, W. E., Koroshetz, W. J., Manly, J. J., Mayeux, R., et al. (2011) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2011.03.005 · Cited by 18,657 · see citing works
Cortical Surface-Based Analysis
Dale, A. M., Fischl, B., & Sereno, M. I. (1999) · NeuroImage · doi:10.1006/nimg.1998.0395 · Cited by 10,910 · see citing works
Correspondence of the brain's functional architecture during activation and rest
Smith, S. M., Fox, P. T., Miller, K. L., Glahn, D. C., Fox, P. M., Mackay, C. E., Filippini, N., Watkins, K. E., Toro, R., Laird, A. R., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905267106 · Cited by 5,150 · see citing works
Classification of primary progressive aphasia and its variants
Gorno-Tempini, M. L., Hillis, A. E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S. F., Ogar, J. M., Rohrer, J. D., Black, S., Boeve, B. F., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821103e6 · Cited by 5,141 · see citing works
Self-citationGreicius, M. D., Srivastava, G., Reiss, A. L., & Menon, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308627101 · Cited by 3,684 · see citing works
Self-citationToward discovery science of human brain function
Biswal, B. B., Mennes, M., Zuo, X.-N., Gohel, S., Kelly, C., Smith, S. M., Beckmann, C. F., Adelstein, J. S., Buckner, R. L., Colcombe, S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911855107 · Cited by 2,970 · see citing works
Buckner, R. L., Sepulcre, J., Talukdar, T., Krienen, F. M., Liu, H., Hedden, T., Andrews-Hanna, J. R., Sperling, R. A., & Johnson, K. A. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5062-08.2009 · Cited by 2,862 · see citing works
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L., & Greicius, M. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.024 · Cited by 2,350 · see citing works
Self-citationResting-State Functional Connectivity Reflects Structural Connectivity in the Default Mode Network
Greicius, M. D., Supekar, K., Menon, V., & Dougherty, R. F. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn059 · Cited by 2,175 · see citing works
Self-citationNelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050 · cited 1× · see citing works
“…to clinical symptoms is consistent with the vast majority of clinicopathological studies that have found that tangle pathology is a better predictor of neurodegeneration , disease severity and cognitive symptoms in Alzheimer's disease than amyloid pathology (see Nelson et al., 2012 for a review).”
ResultAβ Oligomers – a decade of discovery
Walsh, D. M., & Selkoe, D. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04426.x · Cited by 1,938 · see citing works
Mucke, L., Masliah, E., Yu, G.-Q., Mallory, M., Rockenstein, E. M., Tatsuno, G., Hu, K., Kholodenko, D., Johnson-Wood, K., & McConlogue, L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04050.2000 · Cited by 1,856 · see citing works
Decoding subject-driven cognitive states with whole-brain connectivity patterns
Shirer, W. R., Ryali, S., Rykhlevskaia, E., Menon, V., & Greicius, M. D. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr099 · Cited by 1,843 · see citing works
Self-citationTransmission and spreading of tauopathy in transgenic mouse brain
Clavaguera, F., Bolmont, T., Crowther, R. A., Abramowski, D., Frank, S., Probst, A., Fraser, G., Stalder, A. K., Beibel, M., Staufenbiel, M., et al. (2009) · Nature Cell Biology · doi:10.1038/ncb1901 · Cited by 1,803 · see citing works
Cognition and anatomy in three variants of primary progressive aphasia
Gorno‐Tempini, M. L., Dronkers, N. F., Rankin, K. P., Ogar, J. M., Phengrasamy, L., Rosen, H. J., Johnson, J. K., Weiner, M. W., & Miller, B. L. (2004) · Annals of Neurology · doi:10.1002/ana.10825 · Cited by 1,608 · see citing works
Self-citationDistribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
Logan, J., Fowler, J. S., Volkow, N. D., Wang, G., Ding, Y., & Alexoff, D. L. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00008 · Cited by 1,515 · see citing works
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
de Calignon, A., Polydoro, M., Suárez-Calvet, M., William, C., Adamowicz, D. H., Kopeikina, K. J., Pitstick, R., Sahara, N., Ashe, K. H., Carlson, G. A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.033 · Cited by 1,427 · see citing works
Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R. W., Bullock, R., Love, S., Neal, J. W., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61075-2 · Cited by 1,416 · cited 2× · see citing works
“…heterogeneity in Alzheimer's disease and Diverging PIB and FDG patterns in Alzheimer's disease Brain 2013: 136; 844–858 | 845 amyloid is particularly timely, given the emergence of therapies that specifically target amyloid-b pathology (Holmes et al., 2008; Salloway et al., 2009).”
BackgroundReiman, E. M., Caselli, R. J., Yun, L. S., Chen, K., Bandy, D., Minoshima, S., Thibodeau, S. N., & Osborne, D. (1996) · New England Journal of Medicine · doi:10.1056/nejm199603213341202 · Cited by 1,366 · see citing works
Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo
Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265 · see citing works
Propagation of Tau Misfolding from the Outside to the Inside of a Cell
Frost, B., Jacks, R. L., & Diamond, M. I. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808759200 · Cited by 1,252 · see citing works
[ <sup>11</sup> C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease
Mintun, M. A., LaRossa, G. N., Sheline, Y. I., Dence, C. S., Lee, S. Y., Mach, R. H., Klunk, W. E., Mathis, C. A., DeKosky, S. T., & Morris, J. C. (2006) · Neurology · doi:10.1212/01.wnl.0000228230.26044.a4 · Cited by 1,036 · see citing works
Selective changes of resting-state networks in individuals at risk for Alzheimer’s disease
Sorg, C., Riedl, V., Mühlau, M., Calhoun, V. D., Eichele, T., Läer, L., Drzezga, A., Förstl, H., Kurz, A., Zimmer, C., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708803104 · Cited by 1,036 · see citing works
Murray, M. E., Graff-Radford, N. R., Ross, O. A., Petersen, R. C., Duara, R., & Dickson, D. W. (2011) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70156-9 · Cited by 972 · see citing works
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
Ikonomovic, M. D., Klunk, W. E., Abrahamson, E. E., Mathis, C. A., Price, J. C., Tsopelas, N. D., Lopresti, B. J., Ziolko, S., Bi, W., Paljug, W. R., et al. (2008) · Brain · doi:10.1093/brain/awn016 · Cited by 933 · see citing works
Neuronal activity regulates the regional vulnerability to amyloid-β deposition
Bero, A. W., Yan, P., Roh, J. H., Cirrito, J. R., Stewart, F. R., Raichle, M. E., Lee, J.-M., & Holtzman, D. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2801 · Cited by 880 · see citing works
Patterns of brain atrophy in frontotemporal dementia and semantic dementia
Rosen, H. J., Gorno–Tempini, M. L., Goldman, W. P., Perry, R. J., Schuff, N., Weiner, M., Feiwell, R., Kramer, J. H., & Miller, B. L. (2002) · Neurology · doi:10.1212/wnl.58.2.198 · Cited by 841 · see citing works
Self-citationBenson, D. F., Davis, R. J., & Snyder, B. D. (1988) · Archives of Neurology · doi:10.1001/archneur.1988.00520310107024 · Cited by 754 · see citing works
A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease
Salloway, S., Sperling, R., Gilman, S., Fox, N. C., Blennow, K., Raskind, M., Sabbagh, M., Honig, L. S., Doody, R., van Dyck, C. H., et al. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c67808 · Cited by 753 · see citing works
Rombouts, S. A. R. B., Barkhof, F., Goekoop, R., Stam, C. J., & Scheltens, P. (2005) · Human Brain Mapping · doi:10.1002/hbm.20160 · Cited by 734 · see citing works
Altered functional connectivity in early Alzheimer's disease: A resting‐state fMRI study
Wang, K., Liang, M., Wang, L. Y., Tian, L., Zhang, X., Li, K., & Jiang, T. (2006) · Human Brain Mapping · doi:10.1002/hbm.20324 · Cited by 727 · see citing works
Kinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B
Price, J. C., Klunk, W. E., Lopresti, B. J., Lu, X., Hoge, J. A., Ziolko, S. K., Holt, D. P., MELTZER, C. C., DeKosky, S. T., & Mathis, C. A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600146 · Cited by 712 · see citing works
Predicting Regional Neurodegeneration from the Healthy Brain Functional Connectome
Zhou, J., Gennatas, E. D., Kramer, J. H., Miller, B. L., & Seeley, W. W. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.004 · Cited by 706 · see citing works
Self-citationThe logopenic/phonological variant of primary progressive aphasia
Gorno‐Tempini, M., Brambati, S. M., Ginex, V., Ogar, J., Dronkers, N. F., Marcone, A., Perani, D., Garibotto, V., Cappa, S. F., & Miller, B. L. (2008) · Neurology · doi:10.1212/01.wnl.0000320506.79811.da · Cited by 700 · see citing works
Self-citationDetection of functional connectivity using temporal correlations in MR images
Hampson, M., Peterson, B. S., Skudlarski, P., Gatenby, J. C., & Gore, J. C. (2002) · Human Brain Mapping · doi:10.1002/hbm.10022 · Cited by 699 · see citing works
Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjects
Mormino, E. C., Kluth, J. T., Madison, C. M., Rabinovici, G. D., Baker, S. L., Miller, B. L., Koeppe, R. A., Mathis, C. A., Weiner, M. W., Jagust, W. J., et al. (2009) · Brain · doi:10.1093/brain/awn320 · Cited by 684 · see citing works
Self-citationSeeding of Normal Tau by Pathological Tau Conformers Drives Pathogenesis of Alzheimer-like Tangles
Guo, J. L., & Lee, V. M.-Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.209296 · Cited by 636 · see citing works
Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy
Tang‐Wai, D. F., Graff‐Radford, N. R., Boeve, B. F., Dickson, D. W., Parisi, J. E., Crook, R., Caselli, R. J., Knopman, D. S., & Petersen, R. C. (2004) · Neurology · doi:10.1212/01.wnl.0000140289.18472.15 · Cited by 624 · see citing works
Galton, C. J. (2000) · Brain · doi:10.1093/brain/123.3.484 · Cited by 613 · see citing works
Sheline, Y. I., Raichle, M. E., Snyder, A. Z., Morris, J. C., Head, D., Wang, S., & Mintun, M. A. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.024 · Cited by 597 · see citing works
Liang, W. S., Reiman, E. M., Valla, J., Dunckley, T., Beach, T. G., Grover, A., Niedzielko, T. L., Schneider, L. E., Mastroeni, D., Caselli, R., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709259105 · Cited by 585 · see citing works
Crutch, S. J., Lehmann, M., Schott, J. M., Rabinovici, G. D., Rossor, M. N., & Fox, N. C. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(11)70289-7 · Cited by 580 · see citing works
Self-citationJueptner, M., & Weiller, C. (1995) · NeuroImage · doi:10.1006/nimg.1995.1017 · Cited by 522 · see citing works
Age-related alterations in default mode network: Impact on working memory performance
Sambataro, F., Murty, V. P., Callicott, J. H., Tan, H.-Y., Das, S., Weinberger, D. R., & Mattay, V. S. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.05.022 · Cited by 517 · see citing works
Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia
Mesulam, M., Wicklund, A., Johnson, N., Rogalski, E., Léger, G. C., Rademaker, A., Weintraub, S., & Bigio, E. H. (2008) · Annals of Neurology · doi:10.1002/ana.21388 · Cited by 513 · see citing works
Kramer, J. H., Jurik, J., Sha, S. J., Rankin, K., Rosen, H. J., Johnson, J. K., & Miller, B. L. (2003) · Cognitive and Behavioral Neurology · doi:10.1097/00146965-200312000-00002 · Cited by 504 · see citing works
Self-citationAge-related Changes in Brain Activity across the Adult Lifespan
Grady, C. L., Springer, M. V., Hongwanishkul, D., McIntosh, A. R., & Winocur, G. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.2.227 · Cited by 497 · see citing works
Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
Johnson, K. A., Gregas, M., Becker, J. A., Kinnecom, C., Salat, D. H., Moran, E. K., Smith, E. E., Rosand, J., Rentz, D. M., Klunk, W. E., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21164 · Cited by 495 · see citing works
Aβ amyloid and glucose metabolism in three variants of primary progressive aphasia
Rabinovici, G. D., Jagust, W. J., Furst, A. J., Ogar, J. M., Racine, C. A., Mormino, E. C., O'Neil, J. P., Lal, R. A., Dronkers, N. F., Miller, B. L., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21451 · Cited by 477 · see citing works
Self-citationEarly-Versus Late-Onset Alzheimer's Disease: More than Age Alone
Koedam, E. L. G. E., Lauffer, V., van der Vlies, A. E., van der Flier, W. M., Scheltens, P., & Pijnenburg, Y. A. L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1337 · Cited by 452 · see citing works
The topography of grey matter involvement in early and late onset Alzheimer's disease
Frisoni, G. B., Pievani, M., Testa, C., Sabattoli, F., Bresciani, L. C., Bonetti, M., Beltramello, A., Hayashi, K. M., Toga, A. W., & Thompson, P. M. (2007) · Brain · doi:10.1093/brain/awl377 · Cited by 436 · see citing works
Miller, S. L., Celone, K., DePeau, K. M., Diamond, E. L., Dickerson, B. C., Rentz, D. M., Pihlajamaki, M. M., & Sperling, R. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706818105 · Cited by 380 · see citing works
Posterior Cortical Atrophy: Clinical Characteristics and Differences Compared to Alzheimer’s Disease
Mendez, M. F., Ghajarania, M., & Perryman, K. M. (2002) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000058331 · Cited by 364 · see citing works
Clinical and pathological characterization of progressive aphasia
Knibb, J., Xuereb, J., Patterson, K., & Hodges, J. R. (2006) · Annals of Neurology · doi:10.1002/ana.20700 · Cited by 346 · see citing works
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
Bacskai, B. J., Frosch, M. P., Freeman, S. H., Raymond, S. B., Augustinack, J. C., Johnson, K. A., Irizarry, M. C., Klunk, W. E., Mathis, C. A., DeKosky, S. T., et al. (2007) · PubMed · doi:10.1001/archneur.64.3.431 · Cited by 341 · see citing works
Mormino, E. C., Smiljic, A., Hayenga, A. O., Onami, S. H., Greicius, M. D., Rabinovici, G. D., Janabi, M., Baker, S. L., Yen, I. V., Madison, C. M., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr025 · Cited by 332 · see citing works
Self-citationSeeded Aggregation and Toxicity of α-Synuclein and Tau
Nonaka, T., Watanabe, S., Iwatsubo, T., & Hasegawa, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.148460 · Cited by 330 · see citing works
Correction of PET Data for Partial Volume Effects in Human Cerebral Cortex by MR Imaging
MELTZER, C. C., Leal, J. P., Mayberg, H. S., Wagner, H. N., & Frost, J. J. (1990) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199007000-00011 · Cited by 329 · see citing works
Progressive posterior cortical dysfunction
Renner, J. A., Burns, J. M., Hou, C. E., McKeel, D. W., Storandt, M., & Morris, J. C. (2004) · Neurology · doi:10.1212/01.wnl.0000140290.80962.bf · Cited by 311 · see citing works
Leyton, C. E., Villemagne, V. L., Savage, S. A., Pike, K. E., Ballard, K. J., Piguet, O., Burrell, J. R., Rowe, C. C., & Hodges, J. R. (2011) · Brain · doi:10.1093/brain/awr216 · Cited by 311 · see citing works
Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE ɛ4 allele
van der Flier, W. M., Pijnenburg, Y. A. L., Fox, N. C., & Scheltens, P. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(10)70306-9 · Cited by 306 · see citing works
The visual variant of Alzheimer's disease
Levine, D. N., Lee, J. M., & Fisher, C. M. (1993) · Neurology · doi:10.1212/wnl.43.2.305 · Cited by 282 · see citing works
Rabinovici, G. D., Furst, A. J., Alkalay, A., Racine, C. A., O’Neil, J. P., Janabi, M., Baker, S. L., Agarwal, N., Bonasera, S. J., Mormino, E. C., et al. (2010) · Brain · doi:10.1093/brain/awp326 · Cited by 280 · see citing works
Self-citationCognitive Phenotypes in Alzheimer's Disease and Genetic Risk
Snowden, J. S., Stopford, C. L., Julien, C. L., Thompson, J. C., Davidson, Y., Gibbons, L., Pritchard, A., Lendon, C. L., Richardson, A. M., Varma, A., et al. (2007) · Cortex · doi:10.1016/s0010-9452(08)70683-x · Cited by 254 · see citing works
Minoshima, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1995) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199507000-00006 · Cited by 252 · cited 1× · see citing works
“FDG-PET frames were summed and standard uptake volume ratios were calculated by normalizing the summed FDG image to mean activity in the pons for each subject (Minoshima et al., 1995).”
MethodClinical syndromes associated with posterior atrophy
Migliaccio, R., Agosta, F., Rascovsky, K., Karydas, A., Bonasera, S. J., Rabinovici, G. D., Miller, B. L., & Gorno‐Tempini, M. L. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c0d427 · Cited by 252 · see citing works
Self-citationHof, P. R., Vogt, B. A., Bouras, C., & Morrison, J. H. (1997) · Vision Research · doi:10.1016/s0042-6989(96)00240-4 · Cited by 246 · see citing works
Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy
Rosand, J. M., Muzikansky, A., Kumar, A., Wisco, J. J., Smith, E. E., Betensky, R. A., & Greenberg, S. M. (2005) · Annals of Neurology · doi:10.1002/ana.20596 · Cited by 243 · see citing works
Lehmann, M., Crutch, S. J., Ridgway, G. R., Ridha, B. H., Barnes, J., Warrington, E. K., Rossor, M. N., & Fox, N. C. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.08.017 · Cited by 208 · see citing works
Self-citationImaging correlates of posterior cortical atrophy
Whitwell, J. L., Jack, C. R., Kantarci, K., Weigand, S. D., Boeve, B. F., Knopman, D. S., Drubach, D. A., Tang‐Wai, D. F., Petersen, R. C., & Josephs, K. A. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.026 · Cited by 207 · see citing works
Otten, L. J., & Rugg, M. D. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00454-7 · Cited by 190 · see citing works
Structural correlates of early and late onset Alzheimer's disease: voxel based morphometric study
Frisoni, G. B. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.029876 · Cited by 182 · see citing works
Progressive biparietal atrophy: an atypical presentation of Alzheimer's disease.
Ross, S. J., Graham, N. L., Stuart-Green, L., Prins, M., Xuereb, J. H., Patterson, K. E., & Hodges, J. R. (1996) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.61.4.388 · Cited by 177 · see citing works
Mormino, E. C., Brandel, M. G., Madison, C. M., Rabinovici, G. D., Marks, S., Baker, S. L., & Jagust, W. J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.098 · Cited by 158 · see citing works
Self-citationLy, J. V., Donnan, G. A., Villemagne, V. L., Zavala, J. A., Ma, H., O'Keefe, G., Gong, S. J., Gunawan, R. M., Saunder, T., Ackerman, U., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cef7e3 · Cited by 157 · see citing works
Koss, E., Edland, S., Fillenbaum, G., Mohs, R., Clark, C., Galasko, D., & Morris, J. C. (1996) · Neurology · doi:10.1212/wnl.46.1.136 · Cited by 150 · see citing works
Widespread neocortical abnormalities in temporal lobe epilepsy with and without mesial sclerosis
Mueller, S. G., Laxer, K. D., Barakos, J. A., Cheong, I., Garcia, P., & Weiner, M. W. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.02.020 · Cited by 136 · see citing works
Self-citationTemporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis
Whitwell, J., Clifford, R., Przybelski, S., Parisi, J., Senjem, M., Boeve, B., Knopman, D., Petersen, R., Dickson, D., & Josephs, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.10.012 · Cited by 131 · see citing works
Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia
Gefen, T. D., Gasho, K., RADEMAKER, A. W., Lalehzari, M., Weıntraub, S., Rogalski, E. J., Wieneke, C., Bigio, E. H., Geula, C., & Mesulam, M. M. (2012) · Brain · doi:10.1093/brain/aws076 · Cited by 131 · see citing works
Rogalski, E. J., Johnson, N., Weıntraub, S., & Mesulam, M. M. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.34 · Cited by 129 · see citing works
Similar amyloid-β burden in posterior cortical atrophy and Alzheimer's disease
de Souza, L. C., Corlier, F. W., Habert, M., Uspenskaya, O., Maroy, R., Lamari, F., Marie Chupin, A., Lehéricy, S., Olivier Colliot, A., Hahn‐Barma, V., et al. (2011) · Brain · doi:10.1093/brain/awr130 · Cited by 127 · see citing works
Distinct clinical and metabolic deficits in PCA and AD are not related to amyloid distribution
Rosenbloom, M. H., Alkalay, A., Agarwal, N., Baker, S. L., O’Neil, J. P., Janabi, M., Yen, I. V., Growdon, M. E., Jang, J., Madison, C. M., et al. (2011) · Neurology · doi:10.1212/wnl.0b013e31821cccad · Cited by 121 · see citing works
Self-citationJosephs, K. A., Duffy, J. R., Fossett, T., Strand, E. A., Claassen, D. O., Whitwell, J. L., & Peller, P. J. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.78 · Cited by 115 · see citing works
Lehmann, M., Rohrer, J. D., Clarkson, M. J., Ridgway, G. R., Scahill, R. I., Marc Modat, A., Warren, J. D., Sebastien Ourselin, A., Barnes, J., Rossor, M. N., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1401 · Cited by 102 · see citing works
Self-citationPreclinical Evidence of Alzheimer Changes
Petrie, E. C., Cross, D. J., Galasko, D. R., Schellenberg, G. D., Raskind, M. A., Peskind, E. R., & Minoshima, S. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.59 · Cited by 101 · see citing works
Fripp, J., Bourgeat, P., Acosta, O., Raniga, P., Modat, M., Pike, K. E., Jones, G., O'Keefe, G., Masters, C. L., Ames, D., et al. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.053 · Cited by 80 · cited 4× · see citing works
“…in mouse models correlate with neural activity (Cirrito et al., 2005; Bero et al., 2011), and that amyloid-b accumulation in humans occurs in highly interconnected cortical hubs (Buckner et al., 2009), even in preclinical stages (Mintun et al., 2006; Fripp et al., 2008; Mormino et al., 2011).”
BackgroundInfluentialNg, S., Villemagne, V. L., Masters, C. L., & Rowe, C. C. (2007) · Archives of Neurology · doi:10.1001/archneur.64.8.1140 · Cited by 79 · see citing works
Formaglio, M., Costes, N., Seguin, J., Tholance, Y., Bars, D. L., Roullet‐Solignac, I., Mercier, B., Krolak‐Salmon, P., & Vighetto, A. (2011) · Journal of Neurology · doi:10.1007/s00415-011-6030-0 · Cited by 71 · see citing works
Global gray matter changes in posterior cortical atrophy: A serial imaging study
Lehmann, M., Barnes, J., Ridgway, G. R., Ryan, N. S., Warrington, E. K., Crutch, S. J., & Fox, N. C. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.09.225 · Cited by 49 · see citing works
Self-citationPosterior Cortical Atrophy: A Rare Form of Dementia with in vivo Evidence of Amyloid-β Accumulation
Tenovuo, O. S., Kemppainen, N. M., Aalto, S., et al. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-15301 · Cited by 38 · see citing works
Shiino, A., Watanabe, T., Kitagawa, T., Kotani, E., Takahashi, J., Morikawa, S., & Akiguchi, I. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000151241 · Cited by 37 · see citing works
Kambe, T., Motoi, Y., Ishii, K., & Hattori, N. (2009) · Journal of Neurology · doi:10.1007/s00415-009-5377-y · Cited by 27 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, et al. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology 2006; 67: 446-52.
- Zhou J, Gennatas ED, Kramer JH, Miller BL, Seeley WW. Predicting re- gional neurodegeneration from the healthy brain functional connec- tome. Neuron 2012; 73: 1216-27.
Cited by
Sorted by citations
Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Dubois, B., Feldman, H. H., Jacova, C., Hampel, H., Molinuevo, J. L., Blennow, K., DeKosky, S. T., Gauthier, S., Selkoe, D., Bateman, R., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70090-0 · Cited by 3,321 · see citing works
Self-citationKnopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606 · see citing works
New insights into atypical Alzheimer's disease in the era of biomarkers
Graff-Radford, J., Yong, K. X. X., Apostolova, L. G., Bouwman, F. H., Carrillo, M., Dickerson, B. C., Rabinovici, G. D., Schott, J. M., Jones, D. T., & Murray, M. E. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30440-3 · Cited by 706 · see citing works
Self-citationGordon, B. A., Blazey, T. M., Su, Y., Hari-Raj, A., Dincer, A., Flores, S., Christensen, J., McDade, E., Wang, G., Xiong, C., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30028-0 · Cited by 602 · see citing works
Self-citationImaging the evolution and pathophysiology of Alzheimer disease
Jagust, W. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0067-3 · Cited by 604 · see citing works
Self-citationBlood–Brain Barrier Dysfunction as a Cause and Consequence of Alzheimer's Disease
Erickson, M. A., & Banks, W. A. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.135 · Cited by 572 · see citing works
Ossenkoppele, R., Pijnenburg, Y. A. L., Perry, D. C., Cohn-Sheehy, B. I., Scheltens, N. M. E., Vogel, J. W., Kramer, J. H., van der Vlies, A. E., Joie, R. L., Rosen, H. J., et al. (2015) · Brain · doi:10.1093/brain/awv191 · Cited by 548 · see citing works
Self-citationAmyloid biomarkers in Alzheimer's disease
Blennow, K., Mattsson, N., Schöll, M., Hansson, O., & Zetterberg, H. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.03.002 · Cited by 470 · see citing works
Murray, M. E., Lowe, V. J., Graff-Radford, N. R., Liesinger, A. M., Cannon, A., Przybelski, S. A., Rawal, B., Parisi, J. E., Petersen, R. C., Kantarci, K., et al. (2015) · Brain · doi:10.1093/brain/awv050 · Cited by 324 · see citing works
Mesulam, M.-M., Weintraub, S., Rogalski, E. J., Wieneke, C., Geula, C., & Bigio, E. H. (2014) · Brain · doi:10.1093/brain/awu024 · Cited by 334 · see citing works
Brain fluorodeoxyglucose (FDG) PET in dementia
Kato, T., Inui, Y., Nakamura, A., & Ito, K. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.02.003 · Cited by 236 · see citing works
Branger, P., Arenaza-Urquijo, E. M., Tomadesso, C., Mézenge, F., André, C., de Flores, R., Mutlu, J., de La Sayette, V., Eustache, F., Chételat, G., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.02.009 · Cited by 186 · see citing works
18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes
Tsai, R. M., Bejanin, A., Lesman-Segev, O., LaJoie, R., Visani, A., Bourakova, V., O’Neil, J. P., Janabi, M., Baker, S., Lee, S. E., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0470-7 · Cited by 164 · see citing works
Self-citationLocal and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease
Iaccarino, L., Tammewar, G., Ayakta, N., Baker, S. L., Bejanin, A., Boxer, A. L., Gorno-Tempini, M. L., Janabi, M., Kramer, J. H., Lazaris, A., et al. (2018) · NeuroImage: Clinical · doi:10.1016/j.nicl.2017.09.016 · Cited by 165 · see citing works
Self-citationBhagwat, N., Viviano, J. D., Voineskos, A. N., Chakravarty, M. M., & Initiative, A. D. N. (2018) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1006376 · Cited by 157 · see citing works
Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer’s disease
Myers, N., Pasquini, L., Göttler, J., Grimmer, T., Koch, K., Ortner, M., Neitzel, J., Mühlau, M., Förster, S., Kurz, A., et al. (2014) · Brain · doi:10.1093/brain/awu103 · Cited by 132 · see citing works
Lehmann, M., Madison, C. M., Ghosh, P. M., Seeley, W. W., Mormino, E., Greicius, M. D., Gorno-Tempini, M. L., Kramer, J. H., Miller, B. L., Jagust, W. J., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221536110 · Cited by 122 · see citing works
Self-citationHenry, M. L., Hubbard, H. I., Grasso, S. M., Dial, H. R., Beeson, P. M., Miller, B. L., & Gorno-Tempini, M. L. (2019) · Journal of Speech, Language, and Hearing Research · doi:10.1044/2018_jslhr-l-18-0144 · Cited by 118 · see citing works
Self-citationPreferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing
Chhatwal, J. P., Schultz, A. P., Johnson, K. A., Hedden, T., Jaimes, S., Benzinger, T. L. S., Jack, C., Ances, B. M., Ringman, J. M., Marcus, D. S., et al. (2018) · Brain · doi:10.1093/brain/awy053 · Cited by 101 · see citing works
ApoE influences regional white-matter axonal density loss in Alzheimer's disease
Slattery, C. F., Zhang, J., Paterson, R. W., Foulkes, A. J. M., Carton, A., Macpherson, K., Mancini, L., Thomas, D. L., Modat, M., Toussaint, N., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.04.021 · Cited by 102 · see citing works
Mattsson, N., Insel, P. S., Donohue, M., Jögi, J., Ossenkoppele, R., Olsson, T., Schöll, M., Smith, R., & Hansson, O. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.12.001 · Cited by 92 · see citing works
Staffaroni, A., Elahi, F., McDermott, D., Marton, K., Karageorgiou, E., Sacco, S., Paoletti, M., Caverzasi, E., Hess, C., Rosen, H., et al. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1608808 · Cited by 91 · see citing works
Self-citationUnderstanding the cause of sporadic Alzheimer’s disease
Zetterberg, H., & Mattsson, N. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.915740 · Cited by 73 · see citing works
Diagnosis and Management of Posterior Cortical Atrophy
Yong, K. X. X., Graff-Radford, J., Ahmed, S., Chapleau, M., Ossenkoppele, R., Putcha, D., Rabinovici, G. D., Suarez-Gonzalez, A., Schott, J. M., Crutch, S., et al. (2023) · Current Treatment Options in Neurology · doi:10.1007/s11940-022-00745-0 · Cited by 51 · see citing works
Self-citation
- Authors
- Lehmann, M., Ghosh, P. M., Madison, C., Laforce, R., Corbetta-Rastelli, C., Weiner, M. W., Greicius, M. D., Seeley, W. W., Gorno-Tempini, M. L., Rosen, H. J., Miller, B. L., Jagust, W. J., & Rabinovici, G. D.
- Affiliations
- University of California, San Francisco (US)
- University of California, Berkeley (US)
- San Francisco VA Medical Center (US)
- Stanford Medicine (US)
- Lawrence Berkeley National Laboratory (US)
- Corresponding author
- Lehmann, Manja
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-01-28
- Volume
- 136
- Issue
- 3
- Pages
- 844-858
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC3580269
- OpenAlex
- W2131864441
- Cited by
- 325
- References
- 93
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 9 · 2023: 15 · 2022: 19 · 2021: 32 · 2020: 35 · 2019: 36 · 2018: 22 · 2017: 26 · 2016: 29 · 2015: 39 · 2014: 24 · 2013: 17
- FWCI
- 25.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Brain (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
- Funders
- Alzheimer's Association (K23-AG031861, P50 AG023501, AG027859, NIRG-07-59422, P01-AG1972403, ZEN-08-87090)
- Hellman Family Foundation
- National Institute on Aging (P01 AG1972403, R01AG027859, K23AG031861, P01AG019724, P50AG023501)
- National Institute of Neurological Disorders and Stroke (R01NS073498, R01NS050915)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- Alzheimer's disease, amyloid deposition, glucose hypometabolism, clinical heterogeneity, posterior cortical atrophy, logopenic variant primary progressive aphasia, early-onset Alzheimer's disease, functional networks, frontoparietal network, language network, Pittsburgh compound B, FDG-PET, brain atrophy, temporal lobe, occipital cortex
- MeSH terms
- Aged, Alzheimer Disease, Amyloid, Female, Glucose, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, Phenotype, Radiopharmaceuticals, Fluorodeoxyglucose F18, Positron-Emission Tomography, Plaque, Amyloid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
