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Tumor necrosis factor‐a, interleukin‐lβ, and interleukin‐6 in cerebrospinal fluid from children with prolonged febrile seizures Comparison with acute encephalitis/encephalopathy
Abstract
We investigated the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 alpha (IL-1 beta), and IL-6 as proinflammatory cytokines in CSF to facilitate differentiation between acute encephalitis/encephalopathy and prolonged febrile seizures. We studied 20 children with prolonged febrile seizures and 23 with acute encephalitis/encephalopathy, including 8 with an acellular CSF. TNF-alpha, IL-1 beta, and IL-6 in CSF were measured by ELISA. We found that TNF-alpha, IL-1 beta, and IL-6 were undetectable in CSF of all children with prolonged febrile seizures and control subjects but that the concentrations of TNF-alpha was elevated in 11, of IL-1 alpha in 6, and of IL-6 in 17 of 23 children with acute encephalitis/encephalopathy. Twenty-two of 23 children with acute encephalitis/encephalopathy had elevated concentrations of one or more cytokine. Elevated concentrations of the CSF proinflammatory cytokines, TNF-alpha, IL-1 beta, and IL-6, indicate acute encephalitis/encephalopathy rather than febrile seizures.
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Citations
Cited by
The role of inflammation in epilepsy
Vezzani, A., French, J., Bartfai, T., & Baram, T. Z. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.178 · Cited by 1,876
Epilepsy and brain inflammation
Vezzani, A., Aronica, E., Mazarati, A., & Pittman, Q. J. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.033 · Cited by 603
Interleukin‐1β contributes to the generation of experimental febrile seizures
Dubé, C., Vezzani, A., Behrens, M., Bartfai, T., & Baram, T. Z. (2005) · Annals of Neurology · doi:10.1002/ana.20358 · Cited by 423
Cyclooxygenase-2 (COX-2) inhibitors: future therapeutic strategies for epilepsy management
Rawat, C., Kukal, S., Dahiya, U. R., & Kukreti, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1592-3 · Cited by 162
Huang, F., Pariante, C. M., & Borsini, A. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.09.021 · Cited by 117
Metadata
- Authors
- Ichiyama, T., Nishikawa, M., Yoshitomi, T., Hayashi, T., & Furukawa, S.
- Venue
- Neurology
- Published
- 1998-02
- Volume
- 50
- Issue
- 2
- Pages
- 407-411
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2060079551
- Cited by
- 168
- References
- 0
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tumor necrosis factor‐a, interleukin‐lβ, and interleukin‐6 in cerebrospinal fluid from children with prolonged febrile seizures Comparison with acute encephalitis/encephalopathy. https://app.cochat.ai/papers/10.1212/wnl.50.2.407
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- Ichiyama, T., Nishikawa, M., Yoshitomi, T., Hayashi, T., & Furukawa, S. (1998). Tumor necrosis factor‐a, interleukin‐lβ, and interleukin‐6 in cerebrospinal fluid from children with prolonged febrile seizures Comparison with acute encephalitis/encephalopathy. Neurology. https://doi.org/10.1212/wnl.50.2.407
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