The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Paraneoplastic and oncologic profiles of patients seropositive for type 1 antineuronal nuclear autoantibodies
Abstract
Type 1 antineuronal nuclear autoantibody (ANNA-1, also known as "anti-Hu") is a marker of neurologic autoimmunity that is highly associated with small-cell lung carcinoma (SCLC). To determine the spectrum of symptoms and signs as well as the frequency of cancer in adult patients who are seropositive for ANNA-1, we reviewed 162 sequential patients (67% female) identified as ANNA-1-positive in a comprehensive immunofluorescence screening test. In 21% of these patients, the antibody test requested by the physician was not ANNA-1. By the end of the follow-up period, cancer had been found in 142 patients (88%). Ten of these lacked evidence of SCLC (4 had prostate carcinoma, 3 breast carcinoma, 1 both prostate carcinoma and melanoma, 1 lymphoma, and 1 squamous-cell lung carcinoma). Of the 132 patients (81%) with proven SCLC, 17 had one or more coexisting malignant neoplasms (6 had renal carcinoma, 4 another lung primary carcinoma, 3 prostate carcinoma, 3 breast carcinoma, and 4 assorted neoplasms). The diagnosis of SCLC in 128 patients (97%) followed the onset of paraneoplastic symptoms. SCLC was identified in 10 patients by chest MRI after an equivocal chest radiograph or CT; in 28 by bronchoscopy, mediastinoscopy, or thoracotomy; and in 7 at autopsy. Neurologic signs in decreasing frequency were neuropathy (sensory > mixed somatic > autonomic > cranial [especially cranial nerve VIII] > motor), cerebellar ataxia, limbic encephalitis, polyradiculopathy, associated Lambert-Eaton myasthenic syndrome, myopathy, myelopathy, opsoclonus/myoclonus, motor neuronopathy, brachial plexopathy, and aphasia. Nineteen patients had a solely gastrointestinal initial presentation, including gastroparesis, pseudo-obstruction, esophageal achalasia, or other dysmotility. We conclude that seropositivity for ANNA-1 can expedite the diagnosis and treatment of otherwise occult cancer in patients, especially tobacco abusers, with varied neurologic and gastroenterologic presentations. The search for SCLC should not end on discovering a different neoplasm.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Seropositivity for any of the above-mentioned antibodies may therefore prompt further investigation for occult malignancy (e.g. whole-body fluorodeoxyglucose-positron emission tomography).”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [432]
Citations
Cites
Dalmau, J., Graus, F., Rosenblum, M. K., & Posner, J. B. (1992) · MEDICINE · doi:10.1097/00005792-199203000-00001 · Cited by 819
Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
Zbar, B., Brauch, H. B., Talmadge, C., & Linehan, W. M. (1987) · Nature · doi:10.1038/327721a0 · Cited by 637
Walsh and Hoyt's Clinical Neuro-Ophthalmology
(1989) · Archives of Ophthalmology · doi:10.1001/archopht.1989.01070020357030 · Cited by 606
Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J. B., & Furneaux, H. M. (1991) · Cell · doi:10.1016/0092-8674(91)90184-z · Cited by 553
Miller, D. H., Albert, P. S., Barkhof, F., Francis, G., Frank, J. A., Hodgkinson, S., Lublin, F. D., Paty, D. W., Reingold, S. C., & Simon, J. (1996) · Annals of Neurology · doi:10.1002/ana.410390104 · Cited by 444
Dalmau, J. O., Furneaux, H. M., Gralla, R. J., Kris, M. G., & Posner, J. B. (1990) · Annals of Neurology · doi:10.1002/ana.410270515 · Cited by 391
Megadose corticosteroids in multiple sclerosis
Kupersmith, M. J., Kaufman, D., Paty, D. W., Ebers, G. C., McFarland, H., Johnson, K., Reingold, S. C., & Whitaker, J. N. (1994) · Neurology · doi:10.1212/wnl.44.1.1 · Cited by 386
Neuronal antinuclear antibody in sensory neuronopathy from lung cancer
Graus, F., Cordon‐Cardo, C., & Posner, J. B. (1985) · Neurology · doi:10.1212/wnl.35.4.538 · Cited by 367
Immunocompromised animal models for the study of antibiotic combinations.
Calandra, T., & Glauser, M. P. (1986) · PubMed · Cited by 287
Dalmau, J. O., Furneaux, H., Cordon‐Cardo, C., & Posner, J. B. (1992) · PubMed Central · Cited by 261
Research works printed but not linked: 5
- Schaumburg H, Kaplan J, Windebank AJ, et al. Sensory neuronopathy from pyridoxine abuse: a new megavitamin syndrome. N Engl J Med 1983;309:445-448.
- Kennelly KD, Dodick DW, Pascuzzi RM, Albain KS, Lennon VA. Neuronal autoantibodies and paraneoplastic neurological syndromes associated with extrapulmonary small cell carcinoma. Neurology 1997;48:A31. Abstract.
- Lhermitte F, Gray F, Lyon-Caen O, Pertuiset BF, Bernard P. Paralysis of digestive tract with lesions of myenteric plexuses: a new paraneoplastic syndrome. Rev Neurol (Paris) 1980;136:825-836.
- 10.1212/WNL.44.1.1 · DOI
- Vernino S Adamski J Lennon VA. Neuronal nicotinic acetylcholine receptor autoantibodies in patients with subacute autonomic neuropathy Isaacs' syndrome or small cell carcinoma-related paraneoplastic disorders. Neurology 1998; in press. Abstract.
Cited by
Sorted by citations
2018 ESC Guidelines for the diagnosis and management of syncope
Brignole, M., Moya, A., de Lange, F. J., Deharo, J.-C., Elliott, P. M., Fanciulli, A., Fedorowski, A., Furlan, R., Kenny, R. A., Martín, A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy037 · Cited by 1,951
Gultekin, S. H. (2000) · Brain · doi:10.1093/brain/123.7.1481 · Cited by 1,110
(2009) · doi:10.1007/978-3-540-29678-2 · Cited by 900
Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients
Graus, F. (2001) · Brain · doi:10.1093/brain/124.6.1138 · Cited by 891
Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
Vernino, S., Low, P. A., Fealey, R. D., Stewart, J. D., Farrugia, G., & Lennon, V. A. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009213431204 · Cited by 674
Self-citation
Metadata
- Authors
- Lucchinetti, C. F., Kimmel, D. W., & Lennon, V. A.
- Affiliations
- Mayo Clinic (US)
- Venue
- Neurology
- Published
- 1998-03
- Volume
- 50
- Issue
- 3
- Pages
- 652-657
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2130696458
- Cited by
- 499
- References
- 50
- Citations by year
- 2026: 10 · 2025: 1 · 2024: 19 · 2023: 13 · 2022: 11 · 2021: 25 · 2020: 20 · 2019: 19 · 2018: 11 · 2017: 18 · 2016: 22 · 2015: 16 · 2014: 12 · 2013: 23 · 2012: 22
- FWCI
- 10.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca037343-11)
- National Cancer Institute (CA-37343)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Keywords
- anti-Hu antibodies, small cell lung cancer, paraneoplastic syndrome, multiple primary neoplasms, gastrointestinal motility disorders, Lambert-Eaton myasthenic syndrome, limbic encephalitis, opsoclonus-myoclonus syndrome, cancer screening, tobacco use, achalasia, gastroparesis
- MeSH terms
- Adult, Aged, Autoantibodies, Cerebrospinal Fluid Proteins, Female, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Lung Neoplasms, Male, Middle Aged, Neoplasms, Nerve Tissue Proteins, Nervous System Diseases, Paraneoplastic Syndromes, Incidence, RNA-Binding Proteins, Carcinoma, Small Cell, ELAV Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
