Cited by 269Intracerebral and Subarachnoid Hemorrhage ResearchAlzheimer's disease research and treatmentsCerebrovascular and genetic disorders

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Association of apolipoprotein E ϵ2 and vasculopathy in cerebral amyloid angiopathy

Greenberg, S. M., Vonsattel, J.-P. G., Segal, A. Z., Chiu, R. I., Clatworthy, A. E., Liao, A., Hyman, B. T., Rebeck, G. W.·1998·Neurology

DOI 10.1212/wnl.50.4.961

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Abstract

Objective Hemorrhage related to cerebral amyloid angiopathy (CAA) appears to occur through a multistep pathway that includes deposition of beta-amyloid in cerebral vessels and specific vasculopathic changes in the amyloid-laden vessels, such as cracking of the vessel wall. Recent reports suggest a positive association between CAA-related hemorrhage and both the apolipoprotein E (APOE) epsilon4 allele and, unexpectedly, the APOE epsilon2 allele. Unlike APOE epsilon4, APOE epsilon2 does not appear to act through increased beta-amyloid deposition. We therefore sought to determine whether it might specifically accelerate the second step in this pathway, that is, development of the vasculopathic changes that lead to hemorrhage. Methods To determine the role of APOE in development of vasculopathic changes, we compared APOE genotypes in two groups of postmortem brains: 52 brains with complete amyloid replacement of vessel walls but without vasculopathic changes, and 23 brains with complete amyloid replacement of vessels with the accompanying changes of cracking of the vessel wall and paravascular leaking of blood. Results Frequency of APOE epsilon2 was significantly greater in the group with vasculopathy (0.09) than the group without (0.01, p = 0.03). The groups did not differ in mean age or extent of neuritic plaques. Analysis of a clinical series of patients with CAA-related hemorrhage confirmed an overrepresentation of APOE epsilon2 as well as an association between this allele a…

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Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome): Report of the NINDS-SPSP International Workshop*
Litvan, I., Agid, Y., Calne, D., Campbell, G., Dubois, B., Duvoisin, R. C., Goetz, C. G., Golbe, L. I., Grafman, J., Growdon, J. H., et al. (1996) · Neurology · doi:10.1212/wnl.47.1.1 · Cited by 2,538
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.
Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.20.9649 · Cited by 1,525
Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study
Vonsattel, J. P. G., Myers, R. H., Tessa Hedley‐Whyte, E., Ropper, A. H., Bird, E. D., & Richardson, E. P. (1991) · Annals of Neurology · doi:10.1002/ana.410300503 · Cited by 662
Self-citation
A Comparison of Symptoms after the Consumption of Milk or Lactose-Hydrolyzed Milk by People with Self-Reported Severe Lactose Intolerance
Suarez, F. L., Savaiano, D. A., & Levitt, M. D. (1995) · New England Journal of Medicine · doi:10.1056/nejm199507063330101 · Cited by 508
Guidelines for the use of magnetic resonance techniques in monitoring the treatment of multiple sclerosis
Miller, D. H., Albert, P. S., Barkhof, F., Francis, G., Frank, J. A., Hodgkinson, S., Lublin, F. D., Paty, D. W., Reingold, S. C., & Simon, J. (1996) · Annals of Neurology · doi:10.1002/ana.410390104 · Cited by 444
Neurosurgical horizons in Parkinson's disease
Goetz, C. G., Long, M. R. D., Penn, R. D., & Bakay, R. A. E. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.1 · Cited by 405
Factors That Predict the Bleeding Risk of Cerebral Arteriovenous Malformations
Pollock, B. E., Flíckinger, J. C., Lunsford, L. D., Bissonette, D. J., & Kondziolka, D. S. (1996) · Stroke · doi:10.1161/01.str.27.1.1 · Cited by 367
Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease
Evans, K. C., Berger, E. P., Cho, C. G., Weisgraber, K. H., & Lansbury, P. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.763 · Cited by 333
Autosomal dominant cerebellar phenotypes
Rosenberg, R. N. (1990) · Neurology · doi:10.1212/wnl.45.1.1 · Cited by 315

Show all 23 references

Research works printed but not linked: 14

Vinters HV. Cerebral amyloid angiopathy. A critical review. Stroke 1987;18:311-324.
Mandybur TI. Cerebral amyloid angiopathy: the vascular pathology and complications. J Neuropathol Exp Neurol 1986;45:79-90.
Greenberg SM, Hyman BT. Cerebral amyloid angiopathy and apolipoprotein E: bad news for the good allele? Ann Neurol 1997;41:701-702.
Mayeux R, Stern Y, Ottman R, et al. The apolipoproteinϵ 4 allele in patients with Alzheimer's disease. Ann Neurol 1993;34:752-754.
Premkumar DR, Cohen DL, Hedera P, Friedland RP, Kalaria RN. Apolipoprotein E ϵ 4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer's disease. Am J Pathol 1996;148:2083-2095.
Lippa CF, Smith TW, Saunders AM, Hulette C, Pulaski Salo D, Roses AD. Apolipoprotein E ϵ 2 and Alzheimer's disease: genotype influences pathologic phenotype. Neurology 1997;48:515-519.
Mirra SS, Heyman A, McKeel D, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991;41:479-486.
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron 1994;13:45-53.
Alonzo NC, Hyman BT, Rebeck GW, Greenberg SM. Preferential deposition of Aβ40 in parenchymal versus leptomeningeal vessels in cerebral amyloid angiopathy. Neurology 1997;48:A102-A103. Abstract.
Prelli F, Castano E, Glenner GG, Frangione B. Differences between vascular and plaque core amyloid in Alzheimer's disease. J Neurochem 1988;51:648-651.
Gravina SA, Ho LB, Eckman CB, et al. Amyloid beta protein (a-beta) in Alzheimer's disease brain-biochemical and immunocytochemical analysis with antibodies specific for forms ending at a-beta-40 or a-beta-42(43). J Biol Chem 1995;270:7013-7016.
Davis-Salinas J, Van Nostrand WE. Amyloid beta-protein aggregation nullifies its pathologic properties in cultured cerebrovascular smooth muscle cells. J Biol Chem 1995;270:20887-20890.
Yamaguchi H, Ishiguro K, Sugihara S, et al. Presence of apolipoprotein E on extracellular neurofibrillary tangles and on meningeal blood vessels precedes the Alzheimer beta-amyloid deposition. Acta Neuropathol 1994;88:413-419.
Ma J, Yee A, Brewer HBJ, Das S, Potter H. Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 1994;372:92-94.

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Walker, L., Simpson, H., Thomas, A. J., & Attems, J. (2024) · Figshare · doi:10.6084/m9.figshare.26681218
Additional file 1 of The presence of circulating human apolipoprotein J reduces the occurrence of cerebral microbleeds in a transgenic mouse model with cerebral amyloid angiopathy
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Cerebral amyloid angiopathy: updates on pathophysiology, diagnosis, and management
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Impact des pesticides sur l'agrégation des amyloïdes dans différents modèles de maladies neurodégénératives
Lafon, P. (2019) · theses.fr (ABES) · doi:10.70675/a7f03da1zde57z4475zb05bzc90240451d1c
Contribution à l’étude des anticorps dirigés contre le peptide Aβ et de leur implication dans l’angiopathie amyloïde cérébrale
Chantran, Y. (2020) · theses.fr (ABES) · doi:10.70675/85da59a6z44afz49ecz8d9bz231a28465826
APOE Genotypes Modulate the Relationship of Hypertension With Alzheimer’s Disease: Associations and Clues of Peripheral Mechanisms
Wu, H.-Y., Hou, J., Huang, L.-Y., Tan, L., & Xu, W. (2026) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2026.100773
“Importantly, APOE ε 2 has been associated with fibrinoid necrosis of vascular walls and severe cerebral small vessel disease (28,29), indicating that APOE ε 2 carriers may harbor specific vascular vulnerabilities that become unmasked or amplified under HTN.”
Dementias
Czech, J., Weyland, C. S., Neumann, M., Drzezga, A. E., & Schulz, J. B. (2026) · Springer eBooks · doi:10.1007/978-3-032-13040-2_6
Iatrogenic cerebral amyloid angiopathy: a scoping review
Ikeda, S., Hamaguchi, T., Hirano, T., Yagita, Y., Koga, M., Ihara, M., Nakajima, M., Itabashi, R., Shindo, A., Kudo, K., et al. (2026) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2026-339381
Factors associated with intracerebral hemorrhage in confirmed cerebral amyloid angiopathy
Chaachou-Charradi, A., Burgueño‐García, I., Camacho, J., Moliné, T., Zagrean, N., y Cajal, S. R., Rábano‐Gutierrez, A., Martínez-Sáez, E. A., & Hernández‐Guillamón, M. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71786

Authors: Greenberg, S. M., Vonsattel, J.-P. G., Segal, A. Z., Chiu, R. I., Clatworthy, A. E., Liao, A., Hyman, B. T., & Rebeck, G. W.
Affiliations: Harvard University (US)
ORCID: Greenberg, S. M.
Segal, A. Z.
Clatworthy, A. E.
Hyman, B. T.
Rebeck, G. W.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1998-04
Volume: 50
Issue: 4
Pages: 961-965
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.50.4.961
OpenAlex: W2041396523
Cited by: 267
References: 23
Citations by year: 2026: 7 · 2025: 10 · 2024: 11 · 2023: 6 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 9 · 2016: 4 · 2015: 15 · 2014: 9 · 2013: 15 · 2012: 12
FWCI: 7.43
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: Chinese Academy of Agricultural Sciences
National Institute on Aging (AG14473, AG 12406, AG00725)
Topics: Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Cerebrovascular and genetic disorders
Keywords: cerebral amyloid angiopathy, APOE ε4, intracerebral hemorrhage, vasculopathy, amyloid-beta deposition, postmortem brain
MeSH terms: Age Factors, Aged, Aged, 80 and over, Amyloidosis, Apolipoproteins E, Cerebral Arteries, Cerebral Hemorrhage, Genotype, Humans, Middle Aged, Cohort Studies, Apolipoprotein E2

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Association of apolipoprotein E ϵ2 and vasculopathy in cerebral amyloid angiopathy

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