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Cited by 123Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and DisordersEstrogen and related hormone effects

Use of estrogen in young girls with Turner syndrome: Effects on memory

Ross, J.L., Roeltgen, D., Feuillan, P., Kushner, H., Cutler, G.B.·2000·Neurology
DOI 10.1212/wnl.54.1.164
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Abstract

BACKGROUND: The Turner syndrome (TS) phenotype is characterized by a specific neurocognitive profile of normal verbal skills, impaired visual-spatial and visual-perceptual abilities, and impaired nonverbal more than verbal memory. We compared verbal and nonverbal memory in estrogen- and placebo-treated girls with TS (ages 7 to 9 years) and age-matched female controls. METHODS: Children received either estrogen (ethinyl estradiol, 25 ng/kg/d) or placebo for 1 to 3 years (mean, 2.1+/-0.9 years) in a randomized, double-blind study. Memory and language tasks administered included the Wechsler Intelligence Scale for Children-Revised, Digit Span (forward and backward), the Children's Word List, the Denman Paragraph, the Peabody Picture Vocabulary Test, Boston Naming, immediate and delayed Recall of the Rey Complex Figure, Nonword Reading, Wide Range Achievement Test-Revised reading subtest, Verbal fluency, and the Token Test. RESULTS: The estrogen-treated TS group performed better than the placebo-treated TS group for the Children's Word List immediate and delayed recall and the Digit Span backwards test (p<0.01 to 0.04), although the results were not significant after adjusting for multiple comparisons. The placebo-treated TS group performed less well than the controls for recall of Digit Span backward (p<0.0001; placebo-treated, 2.8+/-1.3; estrogen-treated, 3.4+/-1.2; and controls, 4.2+/-1.3) and immediate and delayed recall of the Children's Word List (delayed recall, p<0.0001; placebo-treated, 6.2+/-3.1; estrogen-treated, 8.0+/-2.9; and controls, 9.0+/-2.9). Performance for these measures was similar for the estrogen-treated TS group and the control group. CONCLUSIONS: Estrogen replacement therapy in young girls with Turner Syndrome is associated with improved verbal and nonverbal memory. The optimal patient age, dose, and duration of estrogen replacement require further study.

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  • One double-blind placebo-controlled trial demonstrated a modest synergistic increase in adult height, normalization of the timing of thelarche for about one-quarter of girls, and modest improvements in cognition and memory.

    “One double-blind, placebo-controlled trial using ultra-low-dose oral ethinyl estradiol as a growth-promoting agent during the prepubertal period combined with GH, followed by a standardized incremental pubertal induction regimen, demonstrated a modest synergistic increase in adult height, normalization of the timing of thelarche for about one-quarter of the girls, and modest improvements in cogni”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [254]

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Authors
Ross, J. L., Roeltgen, D., Feuillan, P., Kushner, H., & Cutler, G. B.
Affiliations
National Institutes of Health (US)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2000-01-11
Volume
54
Issue
1
Pages
164-164
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.54.1.164
OpenAlex
W2136868915
Cited by
123
References
33
Citations by year
2024: 2 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 7 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 3
FWCI
5.27
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS 29857, R01NS029857)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
Turner syndrome, estrogen replacement therapy, ethinyl estradiol, young girls, verbal memory, nonverbal memory, cognitive profile, language development
MeSH terms
Child, Double-Blind Method, Ethinyl Estradiol, Female, Humans, Language, Memory, Mental Recall, Reference Values, Turner Syndrome, Estradiol Congeners

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