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Cited by 334Menopause: Health Impacts and TreatmentsDementia and Cognitive Impairment ResearchEstrogen and related hormone effects

Cognitive function in nondemented older women who took estrogen after menopause

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Jacobs, D. M., Tang, M.-X., Stern, Y., Sano, M., Marder, K., Bell, K. L., Schofield, P., Dooneief, G. +2 more·1998·Neurology
DOI 10.1212/wnl.50.2.368
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Abstract

Investigations of the effects of estrogen replacement on cognitive function in healthy older women have yielded disparate results. We evaluated the relationship between a history of estrogen use and cognitive test performance in 727 women participating in a large community-based study. Participants were followed longitudinally for an average of 2.5 years. Estrogen use history was obtained at baseline. Standardized tests of memory, language, and abstract reasoning were administered at baseline and at follow-up. Results indicate that women who had used estrogen replacement scored significantly higher on cognitive testing at baseline than nonusers, and their performance on verbal memory improved slightly over time. The effect of estrogen on cognition was independent of age, education, ethnicity, and APOE genotype. Results suggest that estrogen replacement therapy may help to maintain cognitive function in nondemented postmenopausal women.

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  • Decreased estradiol reduces executive function.

    “Associations between low E2 and increased ADHD symptoms are in line with evidence that decreased E2 reduces EF (Jacobs et al., 1998; Schmidt et al., 1996; Sherwin, 1997), perhaps particularly among women with genotypic risk for low prefrontal dopamine and elevated trait impulsivity (Jacobs & D’Esposito, 2011).”

    From Reproductive steroids and ADHD symptoms across the menstrual cycle (2018) · cites this paper as Jacobs et al., 1998

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Authors
Jacobs, D. M., Tang, M.-X., Stern, Y., Sano, M., Marder, K., Bell, K. L., Schofield, P., Dooneief, G., Gurland, B., & Mayeux, R.
Affiliations
From the Gertrude H. Sergievsky Center (Drs. Jacobs, Tang, Stem, Sano, Marder, Bell, Schofield, Dooneief, and Mayeux), the Departments of Neurology (Drs. Jacobs, Tang, Stem, Sano, Marder, Bell, Schofield, Dooneief, and Mayeux) and Psychiatry (Drs. Stem, Gurland, and Mayeux), the Taub Center for Alzheimer's Disease Research (Drs. Jacobs, Stern, Sano, Marder, Bell, Dooneief, and Mayeux), the Stroud Center for the Study of Quality of Life (Dr. Gurland), and the Division of Epidemiology (School of...
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-02
Volume
50
Issue
2
Pages
368-373
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.50.2.368
OpenAlex
W2011716448
Semantic Scholar
992b97bdcb25a40b827b0415db691b48e6fc9263
Cited by
332
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 11 · 2014: 4 · 2013: 4 · 2012: 7
FWCI
16.22
Type
journal article
Language
en
Open access
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Columbia Academic Commons (Columbia University)
Funders
National Institute on Aging (AG08702, P01AG007232, AG 07232, P50AG008702, AG10963, R35AG010963)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
estrogen replacement therapy, cognitive function, postmenopausal women, menopause, verbal memory, language, abstract thinking, APOE genotype
MeSH terms
Aged, Apolipoproteins E, Cognition, Female, Genotype, Medicare, Humans, Language, Longitudinal Studies, Memory, Speech, United States, Estrogen Replacement Therapy, Case-Control Studies, Postmenopause

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