Prepubertal ultra-low-dose estrogen therapy is associated with healthier lipid profile than conventional estrogen replacement for pubertal induction in adolescent girls with Turner syndrome: preliminary results
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PURPOSE: The metabolic effects of prepubertal low-dose estrogen replacement (LE) therapy in Turner syndrome (TS) have not been fully investigated to date. The present study aimed to compare glucose and lipids metabolism in adolescents with TS on LE and conventional estrogen replacement (CE). METHODS: In 14 TS (mean age 13.8), LE (17β-estradiol, 62.5 μg daily) was introduced before age 12 (mean age 10.5), and followed by a pubertal induction regimen after age 12, and in 14 CE was started after age 12 (mean 14, SD 1.96). Before, and 3 years after starting 17β-estradiol growth velocity, bone age, BMI, and selected parameters of glucose and lipids metabolism were assessed. RESULTS: There were no significant differences between LE and CE in the mean levels of any parameter before introduction of 17β-estradiol [total cholesterol (TC): 4.1 vs 4.3 mmol/L, LDL cholesterol (LDLc): 2.2 vs 2.4 mmol/L, HDL cholesterol (HDLc): 1.6 vs 1.4 mmol/L, triglycerides: 0.9 vs 1.0 mmol/L, fasting glucose: 4.2 vs 4.4 mmol/L, post-load glucose: 4.8 vs 5.5 mmol/L; fasting insulin: 6.8 vs 8.0 post-load insulin: 21.3 vs 67.0 μIU/mL, HOMA-IR 1.3 vs 1.6]. After three years of treatment, TC and LDLc levels were significantly lower in LE group (3.8 vs 4.4 mmol/L, p = 0.004; 1.9 vs 2.4 mmol/L, p = 0.03). The other parameters did not differ significantly. There was no negative impact on growth course and bone age advancement nor on BMI in LE group. CONCLUSION: Prepubertal LE is associated with healthier lipid profile than CE in girls with TS.
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Studies differ on whether oral E2 vs TD E2 leads to increased total cholesterol and decreased HDL.
“Studies differ on whether oral E2 vs. TD E2 leads to increased total cholesterol and decreased HDL”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [338]
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- Authors
- Ruszala, A., Wojcik, M., Zygmunt-Gorska, A., Janus, D., Wojtys, J., & Starzyk, J. B.
- Affiliations
- Jagiellonian University (PL)
- ORCID
- Starzyk, Jerzy B.
- Venue
- Journal of Endocrinological Investigation
- Published
- 2017-04-10
- Volume
- 40
- Issue
- 8
- Pages
- 875-879
- ISSN
- 0391-4097 (ISSN-L)
- 1720-8386
- PMC
- PMC5514173
- OpenAlex
- W2607326554
- Cited by
- 10
- References
- 24
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 3 · 2020: 3 · 2019: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Endocrinological Investigation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- Jagiellonian University Repository (Jagiellonian University) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- Turner syndrome, puberty induction, estradiol, lipid profile, glucose metabolism, insulin resistance, HOMA-IR, LDL cholesterol, total cholesterol, adolescent girls, bone age, growth rate
- MeSH terms
- Adolescent, Child, Estrogens, Female, Humans, Lipids, Puberty, Turner Syndrome, Biomarkers, Estrogen Replacement Therapy
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