The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Inflammatory cytokines in the pathogenesis of periventricular leukomalacia
Abstract
BACKGROUND: Periventricular leukomalacia (PVL) affects the developing white matter of neonatal brain. Inflammatory and infectious conditions are implicated in the cause of PVL. METHODS: The authors investigated the in situ expression of proinflammatory cytokines (interleukin-1beta and -6, tumor necrosis factor alpha [TNFalpha]), adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1) and inflammatory cell markers (CD68, leukocyte common antigen, human leukocyte antigen II) in 19 neonatal brains with PVL. The authors compared the findings with matched non-PVL brains. RESULTS: The inflammatory reaction detected at the early stage of PVL extends until the latest phase of cystic cavitation, though at an attenuated level. There is high expression of TNFalpha and to a lesser extent interleukin-1beta; interleukin-6 remains undetectable. Cytokine immunoreactivity is detected in PVL cases both with and without infection. However, cytokine production was higher with infection. A different pattern of cytokine expression was observed in anoxic brains without PVL: TNFalpha immunoreactivity was significantly lower than the PVL group. CONCLUSIONS: An immune-mediated inflammatory process may play a role in PVL. TNFalpha, a myelinotoxic factor, may be the major mediator.
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Cites
Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro
Selmaj, K. W., & Raine, C. S. (1988) · Annals of Neurology · doi:10.1002/ana.410230405 · Cited by 1,368
Hagberg, B., Hagberg, G., Olow, I., & Wendt, L. V. (1996) · Acta Paediatrica · doi:10.1111/j.1651-2227.1996.tb14193.x · Cited by 917
Sharief, M. K., & Hentges, R. (1991) · New England Journal of Medicine · doi:10.1056/nejm199108153250704 · Cited by 809
Lee, S. C., Liu, W., Dickson, D. W., Brosnan, C. F., & Berman, J. W. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.150.7.2659 · Cited by 801
Tumor necrosis factor identified in multiple sclerosis brain.
Hofman, F. M., Hinton, D. R., Johnson, K., & Merrill, J. E. (1989) · The Journal of experimental medicine · doi:10.1084/jem.170.2.607 · Cited by 801
Yoon, B. H., Jun, J. K., Romero, R., Park, K. H., Gomez, R., Choi, J.-H., & Kim, I.-O. (1997) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(97)70432-0 · Cited by 756
Periventricular Leukomalacia of Infancy: A Form of Neonatal Anoxic Encephalopathy
BANKER, B. Q. (1962) · Archives of Neurology · doi:10.1001/archneur.1962.04210050022004 · Cited by 716
Friede, R. L. (1989) · Springer eBooks · doi:10.1007/978-3-642-73697-1 · Cited by 605
Yoon, B. H., Romero, R., Yang, S. H., Jun, J. K., Kim, I.-O., Choi, J.-H., & Syn, H. C. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70585-9 · Cited by 584
Neonatal cytokines and coagulation factors in children with cerebral palsy
Nelson, K. B., Dambrosia, J. M., Grether, J. K., & Phillips, T. M. (1998) · Annals of Neurology · doi:10.1002/ana.410440413 · Cited by 549
Cited by
Entry and distribution of microglial cells in human embryonic and fetal cerebral cortex
Monier, A., Adle-Biassette, H., Delezoide, A.-L., Evrard, P., Gressens, P., & Verney, C. (2007) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e3180517b46 · Cited by 291
Oxidative stress disrupts oligodendrocyte maturation
French, H. M., Reid, M., Mamontov, P., Simmons, R. A., & Grinspan, J. B. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22139 · Cited by 246
Chew, L.-J., Fusar-Poli, P., & Schmitz, T. (2013) · Developmental Neuroscience · doi:10.1159/000346157 · Cited by 154
Cai, Z., Lin, S., Pang, Y., & Rhodes, P. G. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000134249.92944.14 · Cited by 111
Cerritelli, F., Frasch, M. G., Antonelli, M. C., Viglione, C., Vecchi, S., Chiera, M., & Manzotti, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.721605 · Cited by 108
Metadata
- Authors
- Kadhim, H., Tabarki, B., Verellen, G., De Prez, C., Rona, A.-M., & Sébire, G.
- Venue
- Neurology
- Published
- 2001-05-22
- Volume
- 56
- Issue
- 10
- Pages
- 1278-1284
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2155368784
- Cited by
- 396
- References
- 35
- FWCI
- 13.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kadhim, H., Tabarki, B., Verellen, G., De Prez, C., Rona, A.-M., & Sébire, G. (2001). Inflammatory cytokines in the pathogenesis of periventricular leukomalacia. Neurology. https://doi.org/10.1212/wnl.56.10.1278
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