CoChat
Sign Up
Cited by 584Neonatal and fetal brain pathologyPreterm Birth and ChorioamnionitisNeonatal and Maternal Infections

Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia

Yoon, Bo Hyun, Romero, Roberto, Yang, Soon Ha, Jun, Jong Kwan, Kim, In-One, Choi, Jung-Hwan, Syn, Hee Chul·1996·American Journal of Obstetrics and Gynecology
DOI 10.1016/s0002-9378(96)70585-9
Open this paper in CoChat — free account

Abstract

Objective Periventricular leukomalacia, a common brain white matter lesion in preterm neonates, is a major risk factor for cerebral palsy. Recently, cytokines (i.e., tumor necrosis factor and interleukin-1(beta)) have been implicated as mediators for the development of periventricular leukomalacia. The purpose of this study was to examine the relationship between umbilical cord plasma levels of tumor necrosis factor-alpha, interleukin-1(beta), interleukin-6, and interleukin-1 receptor antagonist and the occurrence of periventricular leukomalacia in preterm neonates.Study design Umbilical cord blood was collected from 172 consecutive preterm births (25 to 36 weeks). Periventricular leukomalacia-associated lesions were diagnosed by brain ultrasonography within the first 3 days of life. Tumor necrosis factor-alpha, interleukin-1(beta) interleukin-6, and interleukin-1 receptor antagonist were measured by sensitive and specific enzyme-linked immunoassay methods. Umbilical cord arterial pH was measured at birth. Statistical analysis was performed with multiple logistic regression and receiver operating characteristic curve analysis.Results Periventricular leukomalacia-associated lesions were present in 14.5% (25/172) of infants. Plasma concentrations of interleukin-6 but not of tumor necrosis factor-alpha, interleukin-1(beta), and interleukin-1 receptor antagonist were significantly higher in neonates with periventricular leukomalacia-associated lesions than in those without these lesions (median 718, range < 226 to 32,000 pg/ml vs median < 226, range < 226 to 43,670 pg/ml; p < 0.0001). An interleukin-6 value > or = 400 pg/ml had a sensitivity of 72% (18/25) and a specificity of 74% (108/147) in the identification of periventricular leukomalacia-associated lesions. Multivariate analysis showed that umbilical cord interleukin-6 was an independent risk factor for periventricular leukomalacia (odds ratio 6.2, p < 0.002) after correction for known confounding variables (i.e., gestational age at birth, umbilical artery pH, chorioamnionitis).Conclusions Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with periventricular leukomalacia-associated lesions. Our data support the hypothesis that periventricular leukomalacia may be the result of cytokine-mediated brain injury.

Integrity signals

Registry

Crossref · 10.1016/s0002-9378(96)70585-9

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The fetal inflammatory response has been linked to the onset of preterm labour, fetal injury, and long-term handicap including periventricular leucomalacia, cerebral palsy, and chronic lung disease.

    “The fetal inflammatory response has been linked to the onset of preterm labour, and fetal injury and long-term handicap—including periventricular leucomalacia, cerebral palsy, and chronic lung disease.92, 93, 94”

    From Epidemiology and causes of preterm birth (2008) · cites this paper as [92]

Cites

Flagged first, then by citations

1 of the 31 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Yoon, B. H., Romero, R., Yang, S. H., Jun, J. K., Kim, I.-O., Choi, J.-H., & Syn, H. C.
Affiliations
Seoul National University (KR)
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
1996-05
Volume
174
Issue
5
Pages
1433-1440
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/s0002-9378(96)70585-9
OpenAlex
W1964039180
Cited by
584
References
31
Citations by year
2026: 6 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 13 · 2021: 8 · 2020: 8 · 2019: 9 · 2018: 9 · 2017: 22 · 2016: 14 · 2015: 19 · 2014: 22 · 2013: 22 · 2012: 25
FWCI
21.13
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
periventricular leukomalacia, interleukin-6, umbilical cord plasma, preterm infants, white matter lesions, TNF-α, IL-1β, interleukin-1 receptor antagonist, cytokines, cerebral palsy risk, umbilical artery pH, biomarkers, risk factors, brain ultrasonography, gestational age
MeSH terms
Adult, C-Reactive Protein, Female, Fetal Blood, Humans, Immunoenzyme Techniques, Infant, Newborn, Infant, Premature, Interleukin-1, Leukomalacia, Periventricular, Osmolar Concentration, Pregnancy, ROC Curve, Sensitivity and Specificity, Tumor Necrosis Factor-alpha, Interleukin-6, Receptors, Interleukin-1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review