Cited by 119Dementia and Cognitive Impairment ResearchAdvanced MRI Techniques and ApplicationsAlzheimer's disease research and treatments

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Decreased glutamate + glutamine in Alzheimer’s disease detected in vivo with 1 H-MRS at 0.5 T

Antuono, Piero G., Jones, Jennifer L., Wang, Yonker, Li, Shi-Jiang·2001·Neurology

DOI 10.1212/wnl.56.6.737

Open this paper in CoChat — free account

Abstract

OBJECTIVE: To determine whether glutamate + glutamine (GLX) levels in the brain as measured in vivo with proton MRS at 0.5 tesla (T) distinguish between probable Alzheimer's disease and normal aging. BACKGROUND: Glutamatergic markers had been measured previously in postmortem brain tissue. Conventional proton MRS at 1.5 T cannot reliably detect the GLX resonance in vivo. The authors developed a technique at 0.5 T that is sensitive to the GLX resonance. METHODS: Metabolite ratios using creatine and phosphocreatine resonance as an internal standard were acquired from the cingulate region of 18 patients with AD and 12 healthy controls. The major resonances in the spectrum were examined: N-acetylaspartate (NAA), choline-containing compounds, myo-inositol, and GLX. The Mini-Mental State Examination (MMSE) was used to assess cognitive status. The Instrumental Activities of Daily Living Scale (Instrumental ADL) was used to assess functional status. RESULTS: Reduced ratios of GLX (-10%, p = 0.001) and NAA (-12%, p = 0.000) were found in patients with AD. Increased ratios of myo-inositol in patients with AD approached significance (+14%). GLX ratios of patients with AD were correlated with MMSE (r = 0.61, p = 0.007) and Instrumental ADL (r = 0.59, p = 0.01) scores. The combined sensitivity of NAA and myo-inositol in correctly diagnosing AD was 78%. The addition of GLX to NAA and myo-inositol increased the sensitivity to 89%. Overall diagnostic accuracy improved from 80 to 83% with the addition of GLX. CONCLUSIONS: Glutamate + glutamine reduction may be a biologic marker for AD and may be a potential aid in the early clinical diagnosis of AD.

Integrity signals

Registry

Crossref · 10.1212/wnl.56.6.737

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Clinical diagnosis of Alzheimer's disease: Report of the NINCDS‐ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984) · Neurology · doi:10.1212/wnl.34.7.939 · Cited by 27,915
Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living
Lawton, M. P., & Brody, E. M. (1969) · The Gerontologist · doi:10.1093/geront/9.3_part_1.179 · Cited by 18,540
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802
Functional Heterogeneity in Cingulate Cortex: The Anterior Executive and Posterior Evaluative Regions
Vogt, B. A., Finch, D. M., & Olson, C. R. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.6.435-a · Cited by 1,315
Pathological verification of ischemic score in differentiation of dementias
Rosen, W. G., Terry, R. D., Fuld, P. A., Katzman, R., & Peck, A. (1980) · Annals of Neurology · doi:10.1002/ana.410070516 · Cited by 1,273
Glutamate becomes neurotoxic via the N-methyl-d-aspartate receptor when intracellular energy levels are reduced
Novelli, A., Reilly, J. A., Lysko, P. G., & Henneberry, R. C. (1988) · Brain Research · doi:10.1016/0006-8993(88)90765-2 · Cited by 961
Multinuclear NMR Studies on the Energy Metabolism of Glial and Neuronal Cells
Brand, A., Richter‐Landsberg, C., & Leibfritz, D. (1994) · Developmental Neuroscience · doi:10.1159/000111347 · Cited by 889
NMDA Antagonist Neurotoxicity: Mechanism and Prevention
Olney, J. W., Labruyere, J., Wang, G., Wozniak, D. F., Price, M. T., & Sesma, M. A. (1991) · Science · doi:10.1126/science.1835799 · Cited by 841

Show all 42 references

Research works printed but not linked: 2

Hugon J Vallat JM, Dumas M. Role of glutamate and excitotoxicity in neurologic diseases. Rev Neurol (Paris) . 1996; 152: 239–248.
Braak H, Griffing K, Braak E. Neuroanatomy of Alzheimer’s disease. Alzheimer Res . 1997; 3: 235–247.

Sorted by citations

The Glutamatergic System and Alzheimer???s Disease
Butterfield, D. A., & Pocernich, C. B. (2003) · CNS Drugs · doi:10.2165/00023210-200317090-00004 · Cited by 274
On the early diagnosis of Alzheimer's Disease from multimodal signals: A survey
Alberdi, A., Aztiria, A., & Basarab, A. (2016) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2016.06.003 · Cited by 231
Reduced hippocampal glutamate in Alzheimer disease
Rupsingh, R., Borrie, M., Smith, M., Wells, J. L., & Bartha, R. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.05.002 · Cited by 177
Alzheimer’s disease: Targeting the glutamatergic system
Conway, M. E. (2020) · Biogerontology · doi:10.1007/s10522-020-09860-4 · Cited by 180
Loss of VGLUT1 and VGLUT2 in the prefrontal cortex is correlated with cognitive decline in Alzheimer disease
Kashani, A., Lepicard, E. M., Poirel, O., Videau, C., David, J. P., Fallet‐Bianco, C., Simon, A., Delacourte, A., Giros, B., Epelbaum, J., et al. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.010 · Cited by 186
A metabolomic study of the CRND8 transgenic mouse model of Alzheimer's disease
Salek, R. M., Xia, J., Innes, A. E., Sweatman, B. C., Adalbert, R., Randle, S. J., McGowan, E. M., Emson, P. C., & Griffin, J. L. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.04.001 · Cited by 148
Imaging of glutamate neurotransmitter alterations in Alzheimer's disease
Haris, M., Nath, K., Cai, K., Singh, A. K., Crescenzi, R. L., Kogan, F., Verma, G., Reddy, S., Hariharan, H., Melhem, E. R., et al. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2875 · Cited by 152
Astrocytes and Glutamate Homoeostasis in Alzheimer’s Disease: A Decrease in Glutamine Synthetase, But Not in Glutamate Transporter-1, in the Prefrontal Cortex
Kulijewicz‐Nawrot, M., Syková, E., Chvátal, A., Verkhratsky, A., & Rodriguez, J. J. (2013) · ASN NEURO · doi:10.1042/an20130017 · Cited by 142
1H Magnetic resonance spectroscopy in dementia
Kantarci, K. (2007) · British Journal of Radiology · doi:10.1259/bjr/60346217 · Cited by 136
Brain Glutamate Levels Are Decreased in Alzheimer’s Disease: A Magnetic Resonance Spectroscopy Study
Fayed, N., Modrego, P. J., Rojas-Salinas, G., & Aguilar, K. (2011) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317511421780 · Cited by 128
Effects of age and sex on brain glutamate and other metabolites
Chang, L., Jiang, C. S., & Ernst, T. (2008) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2008.06.002 · Cited by 123
Magnetic Resonance Spectroscopy in Alzheimer’s Disease: Systematic Review and Meta-Analysis
Wang, H., Tan, L., Wang, H.-F., Liu, Y., Yin, R.-H., Wang, W.-Y., Chang, X.-L., Jiang, T., & Yu, J.-T. (2015) · Journal of Alzheimer’s Disease · doi:10.3233/jad-143225 · Cited by 123
Proton MR spectroscopy in mild cognitive impairment and Alzheimer disease: comparison of 1.5 and 3 T.
Kantarci, K., Reynolds, G., Petersen, R. C., Boeve, B. F., Knopman, D. S., Edland, S. D., Smith, G. E., Ivnik, R. J., Tangalos, E. G., & Jack, C. R. (2003) · PubMed Central · Cited by 123
Effects of Alzheimer Disease on Fronto-parietal Brain N-acetyl Aspartate and Myo-Inositol Using Magnetic Resonance Spectroscopic Imaging
Zhu, X., Schuff, N. W., Kornak, J., Soher, B. J., Yaffe, K. S., Kramer, J. H., Ezekiel, F., Miller, B. L., Jagust, W. J., & Weiner, M. W. (2006) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000213809.12553.fc · Cited by 122
Reduced glutamate neurotransmission in patients with Alzheimer's disease?an in vivo 13C magnetic resonance spectroscopy study
Lin, A., Shic, F., Enriquez, C. M., & Ross, B. D. (2003) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-003-0004-x · Cited by 115
Regional variations and the effects of age and gender on glutamate concentrations in the human brain
Sailasuta, N., Ernst, T., & Chang, L. (2007) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2007.06.007 · Cited by 112
Proton MR spectroscopic study at 3 Tesla on glutamate/glutamine in Alzheimer’s disease
Hattori, N., Abe, K., Sakoda, S., & Sawada, T. (2002) · Neuroreport · doi:10.1097/00001756-200201210-00041 · Cited by 112
Region- and Age-Specific Changes in Glutamate Transport in the AβPP23 Mouse Model for Alzheimer's Disease
Schallier, A., Smolders, I., Van Dam, D., Loyens, E., De Deyn, P. P., Michotte, A., Michotte, Y., & Massie, A. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-101005 · Cited by 109
Interactions between inflammation, sex steroids, and Alzheimer’s disease risk factors
Uchoa, M. F., Moser, V. A., & Pike, C. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.09.001 · Cited by 105
Glutamine Acts as a Neuroprotectant against DNA Damage, Beta-Amyloid and H2O2-Induced Stress
Chen, J., & Herrup, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033177 · Cited by 97
Magnetic Resonance Spectroscopy and its Applications in Psychiatry
Malhi, G. S., Valenzuela, M., Wen, W. X., & Sachdev, P. S. (2002) · Australian & New Zealand Journal of Psychiatry · doi:10.1046/j.1440-1614.2002.00992.x · Cited by 97
Adeno-Associated Virus Gene Therapy in a Sheep Model of Tay–Sachs Disease
Gray‐Edwards, H. L., Randle, A. N., Maitland, S. A., Benatti, H. R., Hubbard, S. M., Canning, P. F., Vogel, M. B., Brunson, B. L., Hwang, M., Ellis, L. E., et al. (2017) · Human Gene Therapy · doi:10.1089/hum.2017.163 · Cited by 96
Changes in the cellular distribution of glutamine synthetase in Alzheimer's disease
Robinson, S. R. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10057 · Cited by 96
Proton MR Spectroscopy Detected Glutamate/Glutamine Is Increased in Children with Traumatic Brain Injury
Ashwal, S., Holshouser, B. A., Tong, K., Serna, T., Osterdock, R. J., Gross, M., & Kido, D. K. (2004) · Journal of Neurotrauma · doi:10.1089/neu.2004.21.1539 · Cited by 93
1H-MRS evaluation of metabolism in Alzheimer's disease and vascular dementia
Jones, R. S., & Waldman, A. D. (2004) · Neurological Research · doi:10.1179/016164104225017640 · Cited by 90
Molecular and Imaging Biomarkers in Alzheimer’s Disease: A Focus on Recent Insights
Villa, C., Lavitrano, M., Salvatore, E., & Combi, R. (2020) · Journal of Personalized Medicine · doi:10.3390/jpm10030061 · Cited by 94
Pharmacology of Acetylcholinesterase Inhibitors andN‐methyl‐ d ‐aspartate Receptors for Combination Therapy in the Treatment of Alzheimer's Disease
Geerts, H., & Grossberg, G. T. (2006) · The Journal of Clinical Pharmacology · doi:10.1177/0091270006288734 · Cited by 88
Magnetic resonance spectroscopy in Alzheimer’s disease
Kantarci, K., & Radford, G. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s35440 · Cited by 87
Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype
Riese, F., Gietl, A. F., Zoelch, N., Henning, A., Tuura, R., Kälin, A. M., Leh, S. E., Buck, A., Warnock, G., Edden, R. A. E., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.030 · Cited by 81
Cerebral metabolite abnormalities in human immunodeficiency virus are associated with cortical and subcortical volumes
Cohen, R. A., Harezlak, J., Gongvatana, A., Buchthal, S. D., Schifitto, G., Clark, U. S., Paul, R. H., Taylor, M. J., Thompson, P. M., Tate, D. F., et al. (2010) · Journal of NeuroVirology · doi:10.3109/13550284.2010.520817 · Cited by 81
Magnetic resonance imaging of Alzheimer’s disease
Lehéricy, S., Marjańska, M., Mesrob, L., Sarazin, M., & Kinkingnéhun, S. (2006) · European Radiology · doi:10.1007/s00330-006-0341-z · Cited by 75
Magnetic Resonance Imaging Volume of the Angular Gyri Predicts Financial Skill Deficits in People with Amnestic Mild Cognitive Impairment
Griffith, H. R., Stewart, C. C., Stoeckel, L. E., Okonkwo, O. C., den Hollander, J. A., Martin, R. C., Belue, K., Copeland, J. N., Harrell, L. E., Brockington, J. C., et al. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02679.x · Cited by 71
Various MRS Application Tools for Alzheimer Disease and Mild Cognitive Impairment
Gao, F., & Barker, P. B. (2014) · American Journal of Neuroradiology · doi:10.3174/ajnr.a3944 · Cited by 63
Applications of multi-nuclear magnetic resonance spectroscopy at 7T
Stephenson, M. C. (2011) · World Journal of Radiology · doi:10.4329/wjr.v3.i4.105 · Cited by 60
Increased glutamate in the hippocampus after galantamine treatment for Alzheimer disease
Penner, J., Rupsingh, R., Smith, M., Wells, J., BORRIE, M. J., & Bartha, R. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.10.007 · Cited by 57
Glutamate changes in healthy young adulthood
Marsman, A., Mandl, R. C. W., van den Heuvel, M. P., Boer, V. O., Wijnen, J. P., Klomp, D. W. J., Luijten, P. R., & Pol, H. E. H. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.11.003 · Cited by 64
Novel Biomarkers of Human GM1 Gangliosidosis Reflect the Clinical Efficacy of Gene Therapy in a Feline Model
Gray‐Edwards, H. L., Regier, D. S., Shirley, J. L., Randle, A. N., Salibi, N., Thomas, S., Latour, Y. L., Johnston, J. M., Golas, G. A., Maguire, A. S., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.01.009 · Cited by 57
MRI volume of the medial frontal cortex predicts financial capacity in patients with mild Alzheimer’s disease
Stoeckel, L. E., Stewart, C. C., Griffith, H. R., Triebel, K. L., Okonkwo, O. C., den Hollander, J. A., Martin, R. C., Belue, K., Copeland, J. N., Harrell, L. E., et al. (2013) · Brain Imaging and Behavior · doi:10.1007/s11682-013-9226-3 · Cited by 55
Higher Glutamate + Glutamine and Reduction of N-acetylaspartate in Posterior Cingulate According to Age Range in Patients with Cognitive Impairment and/or Pain
Fayed, N. M., Andres, E. M., Viguera, L., Modrego, P. J., & García‐Campayo, J. (2014) · Academic Radiology · doi:10.1016/j.acra.2014.04.009 · Cited by 54
Neuroimaging modalities in the detection of Alzheimer's disease-associated biomarkers
Dang, C., Wang, Y., Li, Q., & Lu, Y. (2023) · Psychoradiology · doi:10.1093/psyrad/kkad009 · Cited by 53
Self-citation
Evidence for altered hippocampal volume and brain metabolites in workers occupationally exposed to lead: A study by magnetic resonance imaging and 1H magnetic resonance spectroscopy
Jiang, Y., Long, L., ZHU, X., ZHENG, H., FU, X., OU, S., WEI, D., Zhou, H., & Zheng, W. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.07.009 · Cited by 53
Proton and Phosphorus Magnetic Resonance Spectroscopy of a Mouse Model of Alzheimer's Disease
Mlynárik, V., Cacquevel, M., Sun-Reimer, L., Janssens, S., Cudalbu, C., Lei, H., Schneider, B. L., Aebischer, P., & Rolf Gruetter, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-112072 · Cited by 52
Proton MR Spectroscopy–Detectable Major Neurotransmitters of the Brain: Biology and Possible Clinical Applications
Agarwal, N., & Renshaw, P. F. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2587 · Cited by 51
Energetics of Excitatory and Inhibitory Neurotransmission in Aluminum Chloride Model of Alzheimer’s Disease: Reversal of Behavioral and Metabolic Deficits by Rasa Sindoor
Saba, K., Rajnala, N., Veeraiah, P., Tiwari, V., Rana, R. K., Lakhotia, S. C., & Patel, A. B. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00323 · Cited by 50
Elevated brain scyllo‐inositol concentrations in patients with Alzheimer's disease
Griffith, H. R., den Hollander, J. A., Stewart, C. C., Evanochko, W. T., Buchthal, S. D., Harrell, L. E., ZAMRINI, E. Y., Brockington, J. C., & Marson, D. C. (2007) · NMR in Biomedicine · doi:10.1002/nbm.1132 · Cited by 50
The relationship between cognitive impairment and in vivo metabolite ratios in patients with clinical Alzheimer's disease and vascular dementia: a proton magnetic resonance spectroscopy study
Waldman, A. D., & Rai, G. S. (2003) · Neuroradiology · doi:10.1007/s00234-003-1040-y · Cited by 48
Magnetic Resonance Spectroscopy in Common Dementias
Kantarci, K. (2013) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2012.10.004 · Cited by 49
Brain metabolism in Alzheimer disease and vascular dementia assessed by in vivo proton magnetic resonance spectroscopy
Herminghaus, S., Frölich, L., Gorriz, C., Pilatus, U. U., Dierks, T., Wittsack, H., Lanfermann, H., Maurer, K., & Zanella, F. E. (2003) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(03)00071-4 · Cited by 45
Seven-Tesla proton magnetic resonance spectroscopic imaging in adult X-linked adrenoleukodystrophy
Ratai, E., Kok, T., Wiggins, C., Wiggins, G., Grant, E., Gagoski, B., O’Neill, G., Adalsteinsson, E., & Eichler, F. (2008) · Archives of Neurology · doi:10.1001/archneur.65.11.1488 · Cited by 37
MR approaches in neurodegenerative disorders
Blamire, A. M. (2018) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2018.11.001 · Cited by 37
The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders
Prajapati, A., Mehan, S., & Khan, Z. (2023) · Biogerontology · doi:10.1007/s10522-023-10034-1 · Cited by 40
Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB‐PET Study
Zeydan, B., Deelchand, D. K., Tosakulwong, N., Lesnick, T. G., Kantarci, O. H., Machulda, M. M., Knopman, D. S., Lowe, V. J., Jack, C. R., Petersen, R. C., et al. (2017) · Journal of Neuroimaging · doi:10.1111/jon.12454 · Cited by 37
Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies
Graff‐Radford, J., Boeve, B. F., Murray, M. E., Ferman, T. J., Tosakulwong, N., Lesnick, T. G., Maroney‐Smith, M., Senjem, M. L., Gunter, J. L., Smith, G. E., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.001 · Cited by 36
Single‐voxel 1 H spectroscopy in the human hippocampus at 3 T using the LASER sequence: characterization of neurochemical profile and reproducibility
Allaïli, N., Valabrègue, R., Auerbach, E. J., Guillemot, V., Yahia‐Cherif, L., Bardinet, É., Jabourian, M., Fossati, P., Lehéricy, S., & Marjańska, M. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3364 · Cited by 36
Circulating Glutamine and Alzheimer’s Disease: A Mendelian Randomization Study
Adams, C. D. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s239350 · Cited by 28
Memantine decreases hippocampal glutamate levels: A magnetic resonance spectroscopy study
Glodzik, L., King, K. G., Gonen, O., Liu, S., Santi, S. D., & de Leon, M. J. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.01.016 · Cited by 28
Brain Metabolic Correlates of Decision Making in Amnestic Mild Cognitive Impairment
Griffith, H. R., Okonkwo, O. C., den Hollander, J. A., Belue, K., Copeland, J., Harrell, L. E., Brockington, J. C., Clark, D. G., & Marson, D. C. (2010) · Aging Neuropsychology and Cognition · doi:10.1080/13825581003646135 · Cited by 28
Meta-analysis of brain metabolite differences in HIV infection
Chelala, L., O’Connor, E. E., Barker, P. B., & Zeffiro, T. A. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102436 · Cited by 26
Imaging Biomarkers in Alzheimer’s Disease: A Practical Guide for Clinicians
Sheikh‐Bahaei, N., Sajjadi, S. A., Manavaki, R., & Gillard, J. H. (2017) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-170013 · Cited by 29
Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System
Wang, Q., Yang, C., Chen, S., & Li, J. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202406867 · Cited by 26
Chapter 6 Proton Magnetic Resonance Spectroscopy In Dementias And Mild Cognitive Impairment
Griffith, H. R., Stewart, C. C., & den Hollander, J. A. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)00406-1 · Cited by 25
Proton Magnetic Resonance Spectroscopy of the Hippocampus in Patients With Mild Cognitive Impairment
Franczak, M. B., Prost, R. W., Antuono, P., Mark, L. P., Jones, J. L., & Ulmer, J. L. (2007) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0b013e318031bc31 · Cited by 25
Self-citation
Magnetic resonance spectroscopy in vivo of neurochemicals in a transgenic model of Alzheimer's disease: A longitudinal study of metabolites, relaxation time, and behavioral analysis in TASTPM and wild‐type mice
Forster, D. M., Davies, K. E., & Williams, S. R. (2012) · Magnetic Resonance in Medicine · doi:10.1002/mrm.24349 · Cited by 24
Alzheimer-like brain metabolic and structural features in cholesterol-fed rabbit detected by magnetic resonance imaging
Jin, P., Pan, Y., Pan, Z., Xu, J., Lin, M. T., Sun, Z., Chen, M., & Xu, M. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0705-9 · Cited by 21
Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice
Gao, J., Zhou, N., Wu, Y., Lu, M., Wang, Q., Xia, C., Zhou, M., & Xu, Y. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03032-9 · Cited by 21
Saturation Transfer MRI for Detection of Metabolic and Microstructural Impairments Underlying Neurodegeneration in Alzheimer’s Disease
Orzyłowska, A., & Oakden, W. (2021) · Brain Sciences · doi:10.3390/brainsci12010053 · Cited by 20
3T hippocampal glutamate-glutamine complex reflects verbal memory decline in aging
Nikolova, S., Stark, S. M., & Stark, C. E. L. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.026 · Cited by 21
Decreased glutamine and glutamate: an early biomarker of neurodegeneration
Zeydan, B., & Kantarci, K. (2021) · International Psychogeriatrics · doi:10.1017/s1041610219001807 · Cited by 20
Cerebral magnetic resonance imaging in quiescent Crohn’s disease patients with fatigue
van Erp, S. J. H., Ercan, E., Breedveld, P., Brakenhoff, L., Ghariq, E., Schmid, S., van Osch, M. J. P., van Buchem, M. A., Emmer, B. J., van der Grond, J., et al. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i6.1018 · Cited by 21
A Review of Glutamate Receptors II: Pathophysiology and Pathology
Rousseaux, C. G. (2008) · Journal of Toxicologic Pathology · doi:10.1293/tox.21.133 · Cited by 19
Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's Disease
Bellanti, F., Bukke, V. N., Moola, A., Villani, R., Scuderi, C., Steardo, L., Palombelli, G., Canese, R., Beggiato, S., Altamura, M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.890855 · Cited by 18
The relationship between measurement of in vivo brain glutamate and markers of iron metabolism: A proton magnetic resonance spectroscopy study in healthy adults
Burger, A., Kotze, M. J., Stein, D. J., van Rensburg, S. J., & Howells, F. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14583 · Cited by 17
Lower Posterior Cingulate N-Acetylaspartate to Creatine Level in Early Detection of Biologically Defined Alzheimer’s Disease
Chen, Q., Abrigo, J., Liu, W., Han, E. Y., Yeung, D. K. W., Shi, L., Au, L. W. C., Deng, M., Chen, S., Leung, E. Y. L., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12060722 · Cited by 15
The Role of Astrocytes in Synaptic Dysfunction and Memory Deficits in Alzheimer’s Disease
de León-López, C. A. M., Navarro‐Lobato, I., & Khan, Z. U. (2025) · Biomolecules · doi:10.3390/biom15070910 · Cited by 19
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer’s Disease
Hinteregger, B., Loeffler, T., Flunkert, S., Neddens, J., Bayer, T. A., Madl, T., & Hutter‐Paier, B. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201204 · Cited by 15
Microbiota-gut-brain axis dysregulation in Alzheimer’s disease and its modulation through probiotic supplementation
Marizzoni, M., Mombelli, E., Alboni, S., Rosa, M., Moretti, D. V., Mirabelli, P., Coppola, L., Luongo, D., Salamone, D., Saleri, S., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106138 · Cited by 17
Whole-brain mapping of metabolic alterations in a mouse model of Alzheimer's disease by desorption electrospray ionization mass spectrometry imaging
Wang, X., Yang, X., Hou, Z., Tian, S., Xu, G., Li, J., Wen, L., Bi, D., Gao, F., Shen, Y., et al. (2022) · Talanta · doi:10.1016/j.talanta.2022.124046 · Cited by 15
Magnetic Resonance Spectroscopy (MRS) in Alzheimer’s Disease
Sheikh‐Bahaei, N., Chen, M., & Pappas, I. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3774-6_9 · Cited by 14
1H- and 13C-NMR spectroscopy of Thy-1-APPSL mice brain extracts indicates metabolic changes in Alzheimer’s disease
Doert, A., Pilatus, U., Zanella, F., Müller, W. E. G., & Eckert, G. P. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1387-3 · Cited by 14
Glutamine as a Potential Neuroprotectant in Alzheimer’s Disease
Chen, J., & Herrup, K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407824-6.00070-7 · Cited by 11
Causal Associations Between Gut Microbiota, Gut Microbiota-Derived Metabolites, and Alzheimer’s Disease: A Multivariable Mendelian Randomization Study
Ning, M., An, L., Dong, L., Zhu, R., Hao, J., Liu, X., & Zhang, Y. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240082 · Cited by 11
Brain Proton MRS is Correlated with Financial Abilities in Patients with Alzheimer’s Disease
Griffith, H. R., Okonkwo, O. C., den Hollander, J. A., Belue, K., Lanza, S., Harrell, L. E., Brockington, J. C., Clark, D. G., & Marson, D. C. (2007) · Brain Imaging and Behavior · doi:10.1007/s11682-007-9002-3 · Cited by 11
Understanding Proton Magnetic Resonance Spectroscopy Neurochemical Changes Using Alzheimer’s Disease Biofluid, PET, Postmortem Pathology Biomarkers, and APOE Genotype
Kara, F., & Kantarci, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810064 · Cited by 10
Glutamatergic and GABAergic metabolite levels in Alzheimer’s disease: a systematic review and meta-analysis
Ebrahimi, R., Soltani, S. M., Masouri, M. M., Seifi, M., Ghafourian, K., & Noori, S. (2025) · BMC Neurology · doi:10.1186/s12883-025-04375-2 · Cited by 11
Metabolomics and mitochondrial dysfunction in Alzheimer’s disease
Kim, D., Gim, J., Yoon, D., Kim, S., & Kim, H. (2016) · Genes & Genomics · doi:10.1007/s13258-016-0494-3 · Cited by 8
MR spectroscopy in Alzheimer’s disease
Sheikh‐Bahaei, N. (2020) · Biomedical Spectroscopy and Imaging · doi:10.3233/bsi-200194 · Cited by 8
Clinical Biomarkers and Novel Drug Targets to Cut Gordian Knots of Alzheimer's Disease
Mir, R. H., Masoodi, M. H., Shah, A. J., Mohi-ud-din, R., Sabreen, S., Wani, T. U., Jan, R., Javed, M. N., & Mir, P. A. (2022) · Current Molecular Pharmacology · doi:10.2174/1874467215666220903095837 · Cited by 6
Glutamine + glutamate level predicts the magnitude of microstructural organization in the gray matter in the healthy elderly
Motegi, T., Narita, K., Fujihara, K., Kasagi, M., Suzuki, Y., Tagawa, M., Ujita, K., Near, J., & Fukuda, M. (2019) · International Psychogeriatrics · doi:10.1017/s1041610219001418 · Cited by 6
Retrospective analysis of Braak stage– and APOE4 allele–dependent associations between MR spectroscopy and markers of tau and neurodegeneration in cognitively unimpaired elderly
Chen, A. M., Gajdošík, M., Ahmed, W., Ahn, S., Babb, J. S., Blessing, E., Boutajangout, A., de Leon, M. J., Debure, L., Gaggi, N. L., et al. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120742 · Cited by 5
DL-3-n-butylphthalide enhances synaptic plasticity in mouse model of brain impairments
Ding, Q., Yu, Q., Lei, T., Guo, Y., Zhao, J., & Yu, J. J. (2022) · STEMedicine · doi:10.37175/stemedicine.v3i1.113 · Cited by 5
Neuroimaging of Alzheimer’s Disease, Mild Cognitive Impairment, and Other Dementias
Risacher, S. L., & Saykin, A. J. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6373-4_19 · Cited by 5
ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer’s disease mice – A new pharmacological target for Glu-related neurotoxicity
Górska, A. M., Santos‐García, I., Kvasnička, A., Dobešová, D., Friedecký, D., Gildenblat, J., & Pahnke, J. (2026) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2026.102891 · Cited by 6
The Cheung Glutamatergic Regimen as a candidate for primary and secondary prevention of Alzheimer's disease onset
Cheung, N. (2026) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823261433953 · Cited by 4
Amyloid pathology induces dysfunction of systemic neurotransmission in aged APPswe/PS2 mice
Oh, S. J., Lee, N., Nam, K. R., Kang, K. J., Han, S. J., Lee, K. C., Lee, Y. J., & Choi, J. Y. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.930613 · Cited by 4
The Glutamatergic System in Alzheimer’s Disease Brain: Dysfunction Associated with Amyloid β-Peptide and Oxidative Stress
Butterfield, D. A. (2004) · Springer eBooks · doi:10.1007/978-1-4419-8959-8_14 · Cited by 3
Effect of ceftriaxone on the glutamate-glutamine cycle and seizure susceptibility of Tg2576 mouse model of Alzheimer's disease
Dejakaisaya, H., Lin, R., Harutyunyan, A., Chan, J., Kwan, P., & Jones, N. C. (2024) · Journal of Alzheimer s Disease · doi:10.1177/13872877241289053 · Cited by 3
Magnetic Resonance Spectroscopy in Dementia
Graff‐Radford, J., & Kantarci, K. (2016) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-33555-1_4 · Cited by 3
Optimized multi-voxel TE-averaged PRESS for glutamate detection in the human brain at 3T
Hatay, G. H., & Öztürk-Işık, E. (2023) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2023.107574 · Cited by 3
Currently Available Neuroimaging Approaches in Alzheimer Disease (AD) Early Diagnosis
Ortiz-Terán, L., Juan, M. R., Martin, M. D. L. N. C., & Ortiz, T. (2011) · InTech eBooks · doi:10.5772/17012 · Cited by 3
Wavelet-based Image Fusion for Enhancement of ROI in CT Image
Hải, N. T. (2014) · Journal of Biomedical Engineering and Medical Imaging · doi:10.14738/jbemi.14.310 · Cited by 3

Authors: Antuono, P. G., Jones, J. L., Wang, Y., & Li, S.-J.
Affiliations: Medical College of Wisconsin (US)
ORCID: Jones, Jennifer L.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-03-27
Volume: 56
Issue: 6
Pages: 737-742
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.56.6.737
OpenAlex: W2101563929
Cited by: 119
References: 42
Citations by year: 2026: 6 · 2025: 4 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 8 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 8 · 2013: 5 · 2012: 6
FWCI: 2.37
Type: journal article
Language: en
Open access: closed
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (5M01-RR00058, M01RR000058)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords: Alzheimer's disease, glutamate/glutamine, 1H NMR, 0.5T MRI, N-acetylaspartate, myo-inositol, brain metabolites, diagnostic biomarkers, early diagnosis, normal aging, cingulate cortex
MeSH terms: Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Brain, Female, Glutamine, Humans, Male, Middle Aged, Magnetic Resonance Spectroscopy, Protons, Glutamic Acid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Decreased glutamate + glutamine in Alzheimer’s disease detected in vivo with 1 H-MRS at 0.5 T

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks