Magnetic Resonance Spectroscopy in Alzheimer’s Disease: Systematic Review and Meta-Analysis

Wang, Hui; Tan, Lan; Wang, Hui-Fu; Liu, Ying; Yin, Rui-Hua; Wang, Wen-Ying; Chang, Xiao-Long; Jiang, Teng; Yu, Jin-Tai

doi:10.3233/jad-143225

Cited by 123Dementia and Cognitive Impairment ResearchAdvanced MRI Techniques and ApplicationsAlzheimer's disease research and treatments

Magnetic Resonance Spectroscopy in Alzheimer’s Disease: Systematic Review and Meta-Analysis

Wang, Hui, Tan, Lan, Wang, Hui-Fu, Liu, Ying, Yin, Rui-Hua, Wang, Wen-Ying, Chang, Xiao-Long, Jiang, Teng +1 more·2015·Journal of Alzheimer’s Disease

DOI 10.3233/jad-143225

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Abstract

Background: The application of non-invasive proton magnetic resonance spectroscopy ( 1 H-MRS) could potentially identify changes in cerebral metabolites in the patients with Alzheimer’s disease (AD). However, whether these metabolites can serve as biomarkers for the diagnosis of AD remains unclear. Objective: Using meta-analysis, we aimed to investigate the patterns of cerebral metabolite changes in several cerebral regions that are strongly associated with cognitive decline in AD patients. Methods: Using Hedges’ g effect size, a systematic search was performed in PubMed, Cochrane Library, Ovid, Embase, and EBSCO, and 38 studies were integrated into the final meta-analysis. Results: According to the observational studies, N-acetyl aspartate (NAA) in AD patients was significantly reduced in the posterior cingulate (PC) (effect size (ES) =−0.924, p < 0.005) and bilateral hippocampus (left hippocampus: ES =−1.329, p < 0.005; right hippocampus: ES =−1.287, p < 0.005). NAA/Cr (creatine) ratio decreased markedly in the PC (ES =−1.052, p < 0.005). Simultaneously, significant elevated myo-inositol (mI)/Cr ratio was found not only in the PC but also in the parietal gray matter. For lack of sufficient data, we failed to elucidate the efficacy of pharmacological interventions with the metabolites changes. Conclusion: The available data indicates that NAA, mI, and the NAA/Cr ratio might be potential biomarkers of brain dysfunction in AD subjects. Choline (Cho)/Cr and mI/NAA changes might also contribute toward the diagnostic process. Thus, large, well-designed studies correlated with cerebral metabolism are needed to better estimate the cerebral extent of alterations in brain metabolite levels in AD patients.

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The range of exposures in frontal cortex and thoracic spinal cord from <1 μg/g to approximately 9 μg/g in these animals largely reflects variability in the success of the intrathecal administration, as previously noted for ASO, rather than nominal dose.
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Mitochondrial Dysfunction, Oxidative Stress, Neuroinflammation, and Metabolic Alterations in the Progression of Alzheimer's Disease: A Meta-Analysis of In Vivo Magnetic Resonance Spectroscopy Studies
Song, T., Song, X., Zhu, C., Patrick, R., Skurla, M., Santangelo, I., Green, M., Harper, D., Ren, B., Forester, B. P., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101503 · Cited by 346 · see citing works
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Xiao, X., Yan, X., Liang, C., & Yang, Y. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1772036 · Cited by 23 · see citing works
Alterations of Brain Metabolites in Adults With HIV
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Nikolova, S., Stark, S. M., & Stark, C. E. L. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.026 · Cited by 21 · see citing works
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Longitudinal GluCEST MRI Changes and Cerebral Blood Flow in 5xFAD Mice
Igarashi, H., Ueki, S., Kitaura, H., Kera, T., Ohno, K., Ohkubo, M., Terumitsu‐Tsujita, M., Kakita, A., & Kwee, I. L. (2020) · Contrast Media & Molecular Imaging · doi:10.1155/2020/8831936 · Cited by 19 · see citing works
Machine learning based on functional and structural connectivity in mild cognitive impairment
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Children with orthostatic intolerance exhibit elevated markers of inflammation in the dorsal medulla
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Chen, X., Li, J., Chen, D., Zhou, Y., Tu, Z., Lin, M., Kang, T., Lin, J., Gong, T., Zhu, L., et al. (2023) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2023.107601 · Cited by 16 · see citing works
The Impact of Acetyl-CoA and Aspartate Shortages on the N-Acetylaspartate Level in Different Models of Cholinergic Neurons
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Imaging and Liquid Biopsy for Distinguishing True Progression From Pseudoprogression in Gliomas, Current Advances and Challenges
Li, K., Zhu, Q., Yang, J., Yin, Z., Du, S., Song, M., Peng, Q., Yang, R., Liu, Y., & Qi, L. (2024) · Academic Radiology · doi:10.1016/j.acra.2024.03.019 · Cited by 15 · see citing works
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Hippocampal metabolism and prefrontal brain structure: A combined 1H-MR spectroscopy, neuropsychological, and voxel-based morphometry (VBM) study
Steinke, J., Christian Gaser, B., Langbein, K., Dietzek, M., Gussew, A., Reichenbach, J. R., Smesny, S., Sauer, H., & Nenadić, I. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.004 · Cited by 15 · see citing works
Metabolite Profile of Alzheimer’s Disease in the Frontal Cortex as Analyzed by HRMAS 1H NMR
Zhang, Y., Liu, Z., Ji, B., Liu, L., Wu, S., Liu, X., Wang, S., & Wang, L. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00424 · Cited by 15 · see citing works
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Zheng, T., Kotol, D., Sjöberg, R., Mitsios, N., Uhlén, M., Zhong, W., Edfors, F., & Mulder, J. (2024) · Glia · doi:10.1002/glia.24569 · Cited by 14 · see citing works
Brain neurometabolites differences in individuals with subjective cognitive decline plus: a quantitative single- and multi-voxel proton magnetic resonance spectroscopy study
Yang, Z., Wan, X., Zhao, X., Yu, R., Wu, Y., Cao, Z., Xie, Q., Luo, M., & Liu, Y. (2021) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-20-1254 · Cited by 13 · see citing works
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Frontal Metabolites and Alzheimer’s Disease Biomarkers in Healthy Older Women and Women Diagnosed with Mild Cognitive Impairment
Hone‐Blanchet, A., Bohsali, A. A., Krishnamurthy, L. C., Shahid, S. S., Lin, Q., Zhao, L., Bisht, A. S., John, S. E., Loring, D. W., Goldstein, F. C., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215431 · Cited by 14 · see citing works
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Alosco, M. L., Jarnagin, J., Rowland, B. C., Liao, H. V., Stern, R. A., & Lin, A. P. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1608764 · Cited by 14 · see citing works
Neurodegenerative changes in the brains of the 5xFAD Alzheimer's disease model mice investigated by high‐field and high‐resolution magnetic resonance imaging and multi‐nuclei magnetic resonance spectroscopy
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Multiparametric MRI for the improved diagnostic accuracy of Alzheimer’s disease and mild cognitive impairment: Research protocol of a case-control study design
Piersson, A. D., Ibrahim, B., Suppiah, S., Mohamad, M., Hassan, H. A., Omar, N. F., Ibrahim, M. I., Yusoff, A. N., Ibrahim, N., Saripan, M. I., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252883 · Cited by 13 · see citing works
Myo-Inositol Levels in the Dorsal Hippocampus Serve as Glial Prognostic Marker of Mild Cognitive Impairment in Mice
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Metabolomics as a Crucial Tool to Develop New Therapeutic Strategies for Neurodegenerative Diseases
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Authors: Wang, H., Tan, L., Wang, H.-F., Liu, Y., Yin, R.-H., Wang, W.-Y., Chang, X.-L., Jiang, T., & Yu, J.-T.
Affiliations: Qingdao University (CN)
Dalian Medical University (CN)
Department of Neurology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, China
Nanjing First Hospital (CN)
Corresponding author: Tan, Lan
Yu, Jin-Tai
ORCID: Wang, Hui
Tan, Lan
Wang, Hui-Fu
Liu, Ying
Jiang, Teng
Yu, Jin-Tai
Venue: Journal of Alzheimer’s Disease
Publisher: SAGE Publications
Published: 2015-06-26
Volume: 46
Issue: 4
Pages: 1049-1070
ISSN: 1387-2877 (ISSN-L)
1875-8908
DOI: 10.3233/jad-143225
OpenAlex: W2315419474
Cited by: 123
References: 95
Citations by year: 2026: 7 · 2025: 6 · 2024: 17 · 2023: 13 · 2022: 21 · 2021: 15 · 2020: 17 · 2019: 9 · 2018: 6 · 2017: 7 · 2016: 4 · 2012: 1
FWCI: 0.78
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Alzheimer s Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords: Alzheimer's disease, 1H NMR
MeSH terms: Alzheimer Disease, Aspartic Acid, Brain, Creatine, Humans, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Protons, Databases, Bibliographic

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Magnetic Resonance Spectroscopy in Alzheimer’s Disease: Systematic Review and Meta-Analysis

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