The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Natural history of mild cognitive impairment in older persons
Abstract
BACKGROUND: Cognitive abilities of older persons range from normal, to mild cognitive impairment, to dementia. Few large longitudinal studies have compared the natural history of mild cognitive impairment with similar persons without cognitive impairment. METHODS: Participants were older Catholic clergy without dementia, 211 with mild cognitive impairment and 587 without cognitive impairment, who underwent annual clinical evaluation for AD and an assessment of different cognitive abilities. Cognitive performance tests were summarized to yield a composite measure of global cognitive function and separate summary measures of episodic memory, semantic memory, working memory, perceptual speed, and visuospatial ability. The authors compared the risk of death, risk of incident AD, and rates of change in global cognition and different cognitive domains among persons with mild cognitive impairment to those without cognitive impairment. All models controlled for age, sex, and education. RESULTS: On average, persons with mild cognitive impairment had significantly lower scores at baseline in all cognitive domains. Over an average of 4.5 years of follow-up, 30% of persons with mild cognitive impairment died, a rate 1.7 times higher than those without cognitive impairment (95% CI, 1.2 to 2.5). In addition, 64 (34%) persons with mild cognitive impairment developed AD, a rate 3.1 times higher than those without cognitive impairment (95% CI, 2.1 to 4.5). Finally, persons with mild cognitive impairment declined significantly faster on measures of episodic memory, semantic memory, and perceptual speed, but not on measures of working memory or visuospatial ability, as compared with persons without cognitive impairment. CONCLUSIONS: Mild cognitive impairment is associated with an increased risk of death and incident AD, and a greater rate of decline in selected cognitive abilities.
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“Tangles are first seen in the entorhinal cortex (EC) (Braak stages I–II), then the hippocampus and thalamus (Braak stages III–IV) and finally the neocortex (Braak stages V–VI), a sequence that is typically synchronous with cognitive decline from mild cognitive impairment to severe dementia1,2,4–7.”
From Single-cell multiregion dissection of Alzheimer’s disease (2024) · cites this paper as [5]
In the citing paper
“Annual evaluations included a uniform structured interview and examination consisting of medical history, neurological examination and cognitive testing by trained personnel who are blind to previous evaluations, as previously described (Bennett, et al., 2002).”
From Cellular, synaptic, and biochemical features of resilient cognition in Alzheimer’s disease (2013) · cites this paper as Bennett, et al., 2002
Citations
Cites
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Regression Models and Life-Tables
Cox, D. R. (1992) · Springer Series in Statistics · doi:10.1007/978-1-4612-4380-9_37 · Cited by 26,297
Mild Cognitive Impairment: Clinical Characterization and Outcome
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Random-Effects Models for Longitudinal Data
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Mild Cognitive Impairment Represents Early-Stage Alzheimer Disease
Morris, J. C., Storandt, M., Miller, J. P., McKeel, D. W., Price, J. L., Rubin, E. H., & Berg, L. (2001) · Archives of Neurology · doi:10.1001/archneur.58.3.397 · Cited by 1,871
Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease
Wilson, R. S. (2002) · JAMA · doi:10.1001/jama.287.6.742 · Cited by 1,352
Self-citation
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- Craik F. A functional account of age differences in memory. In: Klix Hagendorf H eds. Human memory and cognitive capabilities: mechanisms and performances. Amsterdam: Elsevier Science Publishers BV 1986: 409–422.
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Mild cognitive impairment as a diagnostic entity
Petersen, R. C. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01388.x · Cited by 7,864
Gauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 4,094
Self-citationSingle-cell transcriptomic analysis of Alzheimer’s disease
Mathys, H., Davila-Velderrain, J., Peng, Z., Gao, F., Mohammadi, S., Young, J. Z., Menon, M., He, L., Abdurrob, F., Jiang, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1195-2 · Cited by 2,568
Self-citationVitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Petersen, R. C., Thomas, R. G., Grundman, M., Bennett, D., Doody, R., Ferris, S., Galasko, D., Jin, S., Kaye, J., Levey, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050151 · Cited by 1,844
Self-citationMitchell, A. J., & Shiri‐Feshki, M. (2009) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2008.01326.x · Cited by 1,659
Metadata
- Authors
- Bennett, D. A., Wilson, R. S., Schneider, J. A., Evans, D. A., Beckett, L. A., Aggarwal, N. T., Barnes, L. L., Fox, J. H., & Bach, J.
- Affiliations
- University of California System (US)
- ORCID
- Venue
- Neurology
- Published
- 2002-07-23
- Volume
- 59
- Issue
- 2
- Pages
- 198-205
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2075464796
- Cited by
- 1,037
- References
- 46
- Citations by year
- 2026: 40 · 2025: 50 · 2024: 47 · 2023: 47 · 2022: 31 · 2021: 35 · 2020: 34 · 2019: 31 · 2018: 36 · 2017: 37 · 2016: 40 · 2015: 32 · 2014: 52 · 2013: 41 · 2012: 54
- FWCI
- 24.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-15819, AG 10161, AG-14449, P01AG014449, P30AG010161)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- mild cognitive impairment, natural history (disease), older adults, Alzheimer's disease, dementia risk, mortality, cognitive decline, episodic memory, semantic memory, perceptual speed, working memory, visuospatial ability, global cognitive function
- MeSH terms
- Aged, Aged, 80 and over, Cognition, Cognition Disorders, Female, Humans, Male, Memory, Psychometrics, Risk Factors, Severity of Illness Index, Risk Assessment
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