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Cited by 19Thermoregulation and physiological responsesThermal Regulation in MedicineCardiovascular Syncope and Autonomic Disorders

Upright Posture Reduces Thermogenesis and Augments Core Hypothermia

Nakajima, Yasufumi, Takamata, Akira, Ito, Tomoyuki, Sessler, Daniel I., Kitamura, Yoshihiro, Shimosato, Goshun, Taniguchi, Satoshi, Matsuyama, Hiroki +2 more·2002·Anesthesia & Analgesia
DOI 10.1213/00000539-200206000-00053
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Abstract

We recently reported that baroreceptor-mediated reflexes modulate thermoregulatory vasoconstriction during lower abdominal surgery. Accordingly, we examined the hypothesis that postural differences and the related alterations in baroreceptor loading similarly modulate the thermogenic (i.e., shivering) response to hypothermia in humans. In healthy humans (n = 7), cold saline was infused IV (30 mL/kg at 4°C) for 30 min to decrease core temperature. Each participant was studied on 2 separate days, once lying supine and once sitting upright. Tympanic membrane temperature and oxygen consumption were monitored for 40 min after each saline infusion. The decrease in core temperature upon completion of the infusion in the upright posture position was 1.24°C ± 0.07°C, which was significantly greater than the 1.02°C ± 0.06°C seen in the supine position. The core temperature was reduced by 0.59°C ± 0.07°C in the upright position but only by 0.37°C ± 0.05°C in the supine position when the increase in oxygen consumption signaling thermogenic shivering occurred. Thus, the threshold temperature for thermogenesis was significantly less in the upright than the supine position. The gain of the thermogenic response did not differ significantly between the positions (363 ± 69 mL · min−1 · °C−1 for upright and 480 ± 80 mL · min−1 · °C−1 for supine). The skin temperature gradient was significantly larger in the upright than in the supine posture , suggesting that the peripheral vasoconstriction was augmented by upright posture. Plasma norepinephrine concentrations increased in response to cold saline infusion under both conditions, but the increase was significantly larger in the upright than in the supine posture. Baroreceptor unloading thus augments the peripheral vasoconstrictor and catecholamine response to core hypothermia but simultaneously reduces thermogenesis, which consequently aggravated the core temperature decrease in the upright posture.

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Crossref · 10.1213/00000539-200206000-00053

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  • Skin temperature changes with environmental heat and cold, posture, environmental light, anxiety, nutritional status, pain, and stress.

    “Because the skin is rather poikilotherm, its temperature changes with environmental heat and cold. It changes also with posture [61, 78], environmental light [12, 80], anxiety [51], nutritional status [48], pain [36, 42, 54], and stress [72].”

    From Sleep, vigilance, and thermosensitivity (2012) · cites this paper as [61]

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Authors
Nakajima, Y., Takamata, A., Ito, T., Sessler, D. I., Kitamura, Y., Shimosato, G., Taniguchi, S., Matsuyama, H., Tanaka, Y., & Mizobe, T.
Affiliations
  • Kyoto Prefectural University of Medicine (JP)
  • University of Vienna (AT)
Corresponding author
  • Nakajima, Yasufumi
  • Kitamura, Yoshihiro
  • Shimosato, Goshun
  • Taniguchi, Satoshi
  • Matsuyama, Hiroki
  • Tanaka, Yoshifumi
  • Mizobe, Toshiki
ORCID
Venue
Anesthesia & Analgesia
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-06
Volume
94
Issue
6
Pages
1646-1651
ISSN
0003-2999 (ISSN-L)
DOI
10.1213/00000539-200206000-00053
OpenAlex
W2004273111
Cited by
19
References
19
Citations by year
2026: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Anesthesia & Analgesia (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01gm058273-04)
  • National Institute of General Medical Sciences (GM58273)
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
Keywords
upright posture, supine position, thermogenesis, shivering, baroreceptor unloading, peripheral vasoconstriction, oxygen consumption, plasma norepinephrine, skin temperature gradient, thermoregulation, cold saline infusion
MeSH terms
Adult, Blood Pressure, Body Temperature, Body Temperature Regulation, Catecholamines, Heart Rate, Hematocrit, Humans, Hypothermia, Induced, Male, Oxygen, Posture, Pressoreceptors, Shivering, Supine Position, Baroreflex

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