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Cited by 270

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

A zone of frontonasal ectoderm regulates patterning and growth in the face

Hu, Diane, Marcucio, Ralph S., Helms, Jill A.·2003·Development
DOI 10.1242/dev.00397
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Abstract

A fundamental set of patterning genes may define the global organization of the craniofacial region. One of our goals has been to identify these basic patterning genes and understand how they regulate outgrowth of the frontonasal process, which gives rise to the mid and upper face. We identified a molecular boundary in the frontonasal process ectoderm, defined by the juxtaposed domains of Fibroblast growth factor 8 and Sonic hedgehog,which presaged the initial site of frontonasal process outgrowth. Fate maps confirmed that this boundary region later demarcated the dorsoventral axis of the upper beak. Ectopic transplantation of the ectodermal boundary region activated a cascade of molecular events that reprogrammed the developmental fate of neural crest-derived mesenchyme, which resulted in duplications of upper and lower beak structures. We discuss these data in the context of boundary/morphogen models of patterning, and in view of the recent controversy regarding neural crest pre-patterning versus neural crest plasticity.

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Metadata

Authors
Hu, D., Marcucio, R. S., & Helms, J. A.
Venue
Development
Publisher
The Company of Biologists
Published
2003-05-01
Volume
130
Issue
9
Pages
1749-1758
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.00397
OpenAlex
W1999139999
Cited by
270
References
48
FWCI
5.04
Type
journal article
Language
en
Open access
closed

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