The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Interactions between Hox-negative cephalic neural crest cells and the foregut endoderm in patterning the facial skeleton in the vertebrate head
Abstract
The vertebrate face contains bones that differentiate from mesenchymal cells of neural crest origin, which colonize the median nasofrontal bud and the first branchial arches. The patterning of individual facial bones and their relative positions occurs through mechanisms that remained elusive. During the early stages of head morphogenesis, an endodermal cul-de-sac, destined to become Sessel’s pouch, underlies the nasofrontal bud. Reiterative outpocketings of the foregut then form the branchial pouches. We have tested the capacity of endoderm of the avian neurula to specify the facial skeleton by performing ablations or grafts of defined endodermal regions. Neural crest cells that do not express Hox genes respond to patterning cues produced regionally in the anterior endoderm to yield distinct skeletal components of the upper face and jaws. However, Hox-expressing neural crest cells do not respond to these cues. Bone orientation is likewise dependent on the position of the endoderm relative to the embryonic axes. Our findings thus indicate that the endoderm instructs neural crest cells as to the size, shape and position of all the facial skeletal elements, whether they are cartilage or membrane bones.
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Cites
A series of normal stages in the development of the chick embryo
Hamburger, V., & Hamilton, H. L. (1951) · Journal of Morphology · doi:10.1002/jmor.1050880104 · Cited by 12,234
Le Douarin, N., & Kalcheim, C. (1999) · Cambridge University Press eBooks · doi:10.1017/cbo9780511897948 · Cited by 3,014
Self-citationExpression of a Delta homologue in prospective neurons in the chick
Henrique, D., Adam, J., Myat, A., Chitnis, A., Lewis, J., & Ish-Horowicz, D. (1995) · Nature · doi:10.1038/375787a0 · Cited by 992
The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues
Noden, D. M. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90318-4 · Cited by 870
Segmental patterns of neuronal development in the chick hindbrain
Lumsden, A., & Keynes, R. (1989) · Nature · doi:10.1038/337424a0 · Cited by 846
Rhombencephalic neural crest segmentation is preserved throughout craniofacial ontogeny
Köntges, G., & Lumsden, A. (1996) · Development · doi:10.1242/dev.122.10.3229 · Cited by 671
Etchevers, H. C., Vincent, C., Douarin, N. M. L., & F. Couly, G. (2001) · Development · doi:10.1242/dev.128.7.1059 · Cited by 657
Self-citationRijli, F. M., Mark, M., Lakkaraju, S., Dierich, A., Dollé, P., & Chambon, P. (1993) · Cell · doi:10.1016/0092-8674(93)90620-6 · Cited by 634
Gendron-Maguire, M., Mallo, M., Zhang, M., & Gridley, T. (1993) · Cell · doi:10.1016/0092-8674(93)90619-2 · Cited by 553
Segment-specific expression of a zinc-finger gene in the developing nervous system of the mouse
Wilkinson, D. G., Bhatt, S., Chavrier, P., Bravo, R., & Charnay, P. (1989) · Nature · doi:10.1038/337461a0 · Cited by 510
Cited by
Morphological integration and developmental modularity
Klingenberg, C. P. (2008) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev.ecolsys.37.091305.110054 · Cited by 863
Minoux, M., & Rijli, F. M. (2010) · Development · doi:10.1242/dev.040048 · Cited by 507
Cranial neural crest and the building of the vertebrate head
Santagati, F., & Rijli, F. M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1221 · Cited by 461
Cranial neural crest cells on the move: Their roles in craniofacial development
Cordero, D. R., Brugmann, S., Chu, Y., Bajpai, R., Jame, M., & Helms, J. A. (2011) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33702 · Cited by 305
Tremblay, K. D., & Zaret, K. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.01.003 · Cited by 299
Metadata
- Authors
- Couly, G., Creuzet, S., Bennaceur, S., Vincent, C., & Le Douarin, N. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-02-15
- Volume
- 129
- Issue
- 4
- Pages
- 1061-1073
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2156925261
- Cited by
- 420
- References
- 34
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Couly, G., Creuzet, S., Bennaceur, S., Vincent, C., & Le Douarin, N. M. (2002). Interactions between Hox-negative cephalic neural crest cells and the foregut endoderm in patterning the facial skeleton in the vertebrate head. Development. https://doi.org/10.1242/dev.129.4.1061
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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