The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6
Abstract
The transcription factors Pax2 and Pax6 are co-expressed in the entire optic vesicle (OV) prior and concomitant with the establishment of distinct neuroretinal, retinal, pigmented-epithelial and optic-stalk progenitor domains, suggesting redundant functions during retinal determination. Pax2; Pax6 compound mutants display a dose-dependent reduction in the expression of the melanocyte determinant Mitf, accompanied by transdifferentiation of retinal pigmented epithelium (RPE) into neuroretina(NR) in Pax2-/-; Pax6+/- embryos,which strongly resembles the phenotype of Mitf-null mutants. In Pax2-/-; Pax6-/- OVs Mitffails to be expressed and NR markers occupy the area that usually represents the Mitf+ RPE domain. Furthermore, both, Pax2 and Pax6 bind to and activate a MITF RPE-promoter element in vitro,whereas prolonged expression of Pax6 in the Pax2-positive optic stalk leads to ectopic Mitf expression and RPE differentiation in vivo. Together,these results demonstrate that the redundant activities of Pax2 and Pax6 direct the determination of RPE, potentially by directly controlling the expression of RPE determinants.
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Cites
Pax 6: mastering eye morphogenesis and eye evolution
Gehring, W. J., & Ikeo, K. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01776-x · Cited by 758
MyoD is required for myogenic stem cell function in adult skeletal muscle
Megeney, L. A., Kablar, B., Garrett, K., Anderson, J. E., & Rudnicki, M. A. (1996) · Genes & Development · doi:10.1101/gad.10.10.1173 · Cited by 724
Cited by
Melanocytes and the Microphthalmia Transcription Factor Network
Steingrímsson, E., Copeland, N. G., & Jenkins, N. A. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092717 · Cited by 771
Lu, B., Malcuit, C., Wang, S., Girman, S., Francis, P., Lemieux, L., Lanza, R., & Lund, R. (2009) · Stem Cells · doi:10.1002/stem.149 · Cited by 470
Eye development: a view from the retina pigmented epithelium
Ramón Martínez‐Morales, J., Rodrigo, I., & Bovolenta, P. (2004) · BioEssays · doi:10.1002/bies.20064 · Cited by 271
Bharti, K., Nguyen, M. T., Skuntz, S., Bertuzzi, S., & Arnheiter, H. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00318.x · Cited by 237
Bharti, K., Gasper, M., Ou, J., Brucato, M., Clore-Gronenborn, K., Pickel, J., & Arnheiter, H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002757 · Cited by 158
Metadata
- Authors
- Bäumer, N., Marquardt, T., Stoykova, A., Spieler, D., Treichel, D., Ashery-Padan, R., & Gruss, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-07-01
- Volume
- 130
- Issue
- 13
- Pages
- 2903-2915
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2150520945
- Cited by
- 165
- References
- 2
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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