The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois
Abstract
Tbx4 is a member of the T-box family of transcription factor genes, which have been shown to play important roles in development. We have ablated Tbx4 function using targeted mutagenesis in the mouse. Embryos homozygous for the null allele fail to undergo chorioallantoic fusion and die by 10.5 days post coitus. The allantoises of Tbx4-mutant embryos are stunted, apoptotic and display abnormal differentiation. Endothelial cells within mutant allantoises do not undergo vascular remodeling. Heterozygous embryos show a mild, transient growth defect in the allantois. Induction of a hindlimb field occurs normally in Tbx4mutants and initial patterning of the hindlimb bud appears normal. However,hindlimb buds from Tbx4 mutants fail to develop either in vivo or in vitro and do not maintain Fgf10 expression in the mesenchyme. The expression of another, closely-linked, T-box gene, Tbx2, is reduced in both the hindlimb and the allantois of Tbx4-mutant embryos prior to the development of overt morphological abnormalities, which suggests that Tbx4 regulates Tbx2 in these tissues.
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Cites
Jacobs, J. J. L., Keblusek, P., Robanus-Maandag, E., Kristel, P., Lingbeek, M., Nederlof, P. M., van Welsem, T., van de Vijver, M. J., Koh, E. Y., Daley, G. Q., et al. (2000) · Nature Genetics · doi:10.1038/81583 · Cited by 368
Hindlimb patterning and mandible development require the Ptx1 gene
Lanctôt, C., Moreau, A., Chamberland, M., Tremblay, M. L., & Drouin, J. (1999) · Development · doi:10.1242/dev.126.9.1805 · Cited by 311
Role of Pitx1 upstream of Tbx4 in specification of hindlimb identity
Logan, M., & Tabin, C. J. (1999) · Science · doi:10.1126/science.283.5408.1736 · Cited by 304
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Regulation of early lung morphogenesis: questions, facts and controversies
Cardoso, W. V., & Lü, J. (2006) · Development · doi:10.1242/dev.02310 · Cited by 585
Morin-Kensicki, E. M., Boone, B. N., Howell, M., Stonebraker, J. R., Teed, J., Alb, J. G., Magnuson, T. R., O'Neal, W., & Milgram, S. L. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.1.77-87.2006 · Cited by 429
Bernardo, A. S., Faial, T., Gardner, L., Niakan, K. K., Ortmann, D., Senner, C. E., Callery, E. M., Trotter, M. W., Hemberger, M., Smith, J. C., et al. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.06.015 · Cited by 386
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
Koshiba-Takeuchi, K., Takeuchi, J. K., Arruda, E. P., Kathiriya, I. S., Mo, R., Hui, C.-C., Srivastava, D., & Bruneau, B. G. (2006) · Nature Genetics · doi:10.1038/ng1707 · Cited by 170
Tbx3 Represses E-Cadherin Expression and Enhances Melanoma Invasiveness
Rodriguez, M., Aladowicz, E., Lanfrancone, L., & Goding, C. R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0301 · Cited by 157
Metadata
- Authors
- Naiche, L. A., & Papaioannou, V. E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-06-15
- Volume
- 130
- Issue
- 12
- Pages
- 2681-2693
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2130043230
- Cited by
- 250
- References
- 3
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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