The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis
Open accessAbstract
Mammary glands, like other skin appendages such as hair follicles and teeth, develop from the surface epithelium and underlying mesenchyme; however,the molecular controls of embryonic mammary development are largely unknown. We find that activation of the canonical WNT/β-catenin signaling pathway in the embryonic mouse mammary region coincides with initiation of mammary morphogenesis, and that WNT pathway activity subsequently localizes to mammary placodes and buds. Several Wnt genes are broadly expressed in the surface epithelium at the time of mammary initiation, and expression of additional Wnt and WNT pathway genes localizes to the mammary lines and placodes as they develop. Embryos cultured in medium containing WNT3A or the WNT pathway activator lithium chloride (LiCl) display accelerated formation of expanded placodes, and LiCl induces the formation of ectopic placode-like structures that show elevated expression of the placode marker Wnt10b. Conversely, expression of the secreted WNT inhibitor Dickkopf 1 in transgenic embryo surface epithelium in vivo completely blocks mammary placode formation and prevents localized expression of all mammary placode markers tested. These data indicate that WNT signaling promotes placode development and is required for initiation of mammary gland morphogenesis. WNT signals play similar roles in hair follicle formation and thus may be broadly required for induction of skin appendage morphogenesis.
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Cites
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“We generated mice carrying a transgene comprised of the Dkk1coding region downstream of a tetracycline/doxycyclineresponsive promoter (tetO) (Gossen and Bujard, 1992).”
MethodWNT Signals Are Required for the Initiation of Hair Follicle Development
Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088
Self-citationKremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling
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Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation
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Yook, J. I., Li, X.-Y., Ota, I., Hu, C., Kim, H. S., Kim, N. H., Cha, S. Y., Ryu, J. K., Choi, Y. J., Kim, J., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1508 · Cited by 616
Epithelial Stem Cells: Turning over New Leaves
Blanpain, C., Horsley, V., & Fuchs, E. (2007) · Cell · doi:10.1016/j.cell.2007.01.014 · Cited by 594
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Li, J., Sarosi, I., Cattley, R. C., Pretorius, J., Asuncion, F., Grisanti, M., Morony, S., Adamu, S., Geng, Z., Qiu, W., et al. (2006) · Bone · doi:10.1016/j.bone.2006.03.017 · Cited by 441
Pax3 functions at a nodal point in melanocyte stem cell differentiation
Lang, D., Lu, M. M., Huang, L., Engleka, K. A., Zhang, M., Chu, E. Y., Lipner, S., Skoultchi, A., Millar, S. E., & Epstein, J. A. (2005) · Nature · doi:10.1038/nature03292 · Cited by 397
Self-citationZeng, Y. A., & Nusse, R. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.03.020 · Cited by 396
Andl, T., Murchison, E. P., Liu, F., Zhang, Y., Yunta-Gonzalez, M., Tobias, J. W., Andl, C. D., Seykora, J. T., Hannon, G. J., & Millar, S. E. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.005 · Cited by 359
Self-citationScharschmidt, T. C., Vasquez, K. S., Pauli, M. L., Leitner, E. G., Chu, K., Truong, H.-A., Lowe, M. M., Sanchez Rodriguez, R., Ali, N., Laszik, Z. G., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.03.001 · Cited by 258
Self-citationTissue remodelling through branching morphogenesis
Affolter, M., Zeller, R., & Caussinus, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2797 · Cited by 185
Dynamic signals for hair follicle development and regeneration
Wang, X., Tredget, E. E., & Wu, Y. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0230 · Cited by 80
Benham-Pyle, B. W., Sim, J. Y., Hart, K. C., Pruitt, B. L., & Nelson, W. J. (2016) · eLife · doi:10.7554/elife.19799 · Cited by 46
The T-box transcription factor, TBX3, is a key substrate of AKT3 in melanomagenesis
Peres, J., Mowla, S., & Prince, S. (2015) · Oncotarget · doi:10.18632/oncotarget.2782 · Cited by 40
Metadata
- Authors
- Chu, E. Y., Hens, J., Andl, T., Kairo, A., Yamaguchi, T. P., Brisken, C., Glick, A., Wysolmerski, J. J., & Millar, S. E.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-10-01
- Volume
- 131
- Issue
- 19
- Pages
- 4819-4829
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2058004364
- Cited by
- 299
- References
- 4
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- green
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