Neurogenin 2 has an essential role in development of the dentate gyrus
Abstract
The dentate gyrus (DG) of the hippocampus has a central role in learning and memory in adult rodents. The DG is generated soon after birth, although new neurons continue to be generated in the DG throughout life. The proneural factors Mash1 (Ascl1) and neurogenin 2 (Ngn2) are expressed during formation of the DG but their role in the development of this structure has not yet been addressed. Here, we show that Ngn2 is essential for the development of the DG. Ngn2 mutant mice have fewer DG progenitors and these cells present defects in neuronal differentiation. By contrast, the DG is normal in Mash1 mutant mice at birth, and loss of both Mash1 and Ngn2 does not aggravate the defect observed in Ngn2 single mutants. These data establish a unique role of Ngn2 in DG neurogenesis during development and raise the possibility that Ngn2 has a similar function in adult neurogenesis.
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Ngn2-dependent control of HuD transcription is central to neuronal development, function, and dysfunction.
“Given the established function of Ngn2 in neurogenesis (Guillemot 2007) and its emerging roles in learning and memory (Galichet et al. 2008) and neuronal diseases (Rostomily et al. 1997; Andersson et al. 2006; Kele et al. 2006; Uhrig et al. 2009), our findings suggest that Ngn2-dependent control of HuD transcription is central to neuronal development, function, and dysfunction (Fig. 4D).”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Galichet et al. 2008
Cites
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592 · see citing works
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · see citing works
Lemaire, V., Koehl, M., Le Moal, M., & Abrous, D. N. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.20.11032 · Cited by 1,044 · cited 1× · see citing works
“Maintenance of neurogenesis in the adult DG has been suggested to play a role in the acquisition of new memories (Aimone et al., 2006; Gould et al., 1999b; Lemaire et al., 2000).”
BackgroundAltman, J., & Bayer, S. A. (1990) · Journal of Comparative Neurology · doi:10.1002/cne.903010304 · Cited by 819 · see citing works
A role for Cajal–Retzius cells and reelin in the development of hippocampal connections
Del Río, J. A., Heimrich, B., Borrell, V., Förster, E., Drakew, A., Alcántara, S., Nakajima, K., Miyata, T., Ogawa, M., Mikoshiba, K., et al. (1997) · Nature · doi:10.1038/385070a0 · Cited by 472 · see citing works
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The role of adult hippocampal neurogenesis in brain health and disease
Toda, T., Parylak, S. L., Linker, S. B., & Gage, F. H. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0036-2 · Cited by 719 · see citing works
Astrocytes and disease: a neurodevelopmental perspective
Molofsky, A. V., Krenick, R., Ullian, E., Tsai, H.-H., Deneen, B., Richardson, W. D., Barres, B. A., & Rowitch, D. H. (2012) · Genes & Development · doi:10.1101/gad.188326.112 · Cited by 682 · see citing works
Neurogenesis in the embryonic and adult brain: same regulators, different roles
Urbán, N., & Guillemot, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00396 · Cited by 493 · see citing works
Self-citationIwano, T., Masuda, A., Kiyonari, H., Enomoto, H., & Matsuzaki, F. (2012) · Development · doi:10.1242/dev.080002 · Cited by 155 · see citing works
Regulation of Adult Neurogenesis in Mammalian Brain
Niklison-Chirou, M. V., Agostini, M., Amelio, I., & Melino, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144869 · Cited by 143 · see citing works
Bronicki, L. M., & Jasmin, B. J. (2013) · RNA · doi:10.1261/rna.039164.113 · Cited by 126 · see citing works
- Authors
- Galichet, C., Guillemot, F., & Parras, C. M.
- Affiliations
- National Institute for Medical Research (GB)
- Division of Molecular Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2008-06-01
- Volume
- 135
- Issue
- 11
- Pages
- 2031-2041
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2019898412
- Cited by
- 108
- References
- 5
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 7 · 2017: 8 · 2015: 6 · 2014: 12 · 2013: 9 · 2012: 12
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Neurogenin2, dentate gyrus, hippocampus development, proneural genes, ASCL1, neuronal differentiation, neural progenitor cells, adult neurogenesis
- MeSH terms
- Animals, Cell Differentiation, Female, Hippocampus, Immunohistochemistry, Male, Nerve Tissue Proteins, Neurons, In Situ Hybridization, Mice, Knockout, Gene Expression Regulation, Developmental, Dentate Gyrus, In Situ Nick-End Labeling, Green Fluorescent Proteins, Mice, Basic Helix-Loop-Helix Proteins
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