Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus
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The brain is composed of diverse types of neurons that fulfill distinct roles in neuronal circuits, as manifested by the hippocampus, where pyramidal neurons and granule cells constitute functionally distinct domains: cornu ammonis (CA) and dentate gyrus (DG), respectively. Little is known about how these two types of neuron differentiate during hippocampal development, although a set of transcription factors that is expressed in progenitor cells is known to be required for the survival of granule cells. Here, we demonstrate in mice that Prox1, a transcription factor constitutively expressed in the granule cell lineage, postmitotically functions to specify DG granule cell identity. Postmitotic elimination of Prox1 caused immature DG neurons to lose the granule cell identity and in turn terminally differentiate into the pyramidal cell type manifesting CA3 neuronal identity. By contrast, Prox1 overexpression caused opposing effects on presumptive hippocampal pyramidal cells. These results indicate that the immature DG cell has the potential to become a granule cell or a pyramidal cell, and Prox1 defines the granule cell identity. This bi-potency is lost in mature DG cells, although Prox1 is still required for correct gene expression in DG granule cells. Thus, our data indicate that Prox1 acts as a postmitotic cell fate determinant for DG granule cells over the CA3 pyramidal cell fate and is crucial for maintenance of the granule cell identity throughout the life.
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In hepatocytes, corepressor interactions are reported.
“Conversely, in hepatocytes, corepressor interactions are reported43–45, and we found that PROX1 interacted with the repressive NuRD complex in the liver but not in the brain.”
From Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis (2025) · cites this paper as [44]
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- Authors
- Iwano, T., Masuda, A., Kiyonari, H., Enomoto, H., & Matsuzaki, F.
- Affiliations
- RIKEN (JP)
- Corresponding author
- Matsuzaki, Fumio
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2012-08-15
- Volume
- 139
- Issue
- 16
- Pages
- 3051-3062
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2061881084
- Cited by
- 155
- References
- 50
- Citations by year
- 2026: 14 · 2025: 12 · 2024: 17 · 2023: 13 · 2022: 13 · 2021: 16 · 2020: 10 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 14 · 2014: 8 · 2013: 6
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Development (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (24113006)
- RIKEN
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- Prox1, dentate gyrus granule cells, CA3 pyramidal cells, neuronal identity, hippocampal development, transcription factors, neuronal differentiation
- MeSH terms
- Prospero-Related Homeobox 1 Protein, Animals, Cell Differentiation, Mice, Transgenic, Mitosis, Neuronal Plasticity, Neurons, Pyramidal Cells, Mice, Knockout, Homeodomain Proteins, Gene Expression Regulation, Developmental, Dentate Gyrus, Cell Lineage, Tumor Suppressor Proteins, Mice, CA3 Region, Hippocampal
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