The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
GDF11 modulates NGN3+ islet progenitor cell number and promotes β-cell differentiation in pancreas development
Abstract
Identification of endogenous signals that regulate expansion and maturation of organ-specific progenitor cells is a major goal in studies of organ development. Here we provide evidence that growth differentiation factor 11(GDF11), a member of the TGF-β ligand family, governs the number and maturation of islet progenitor cells in mouse pancreas development. Gdf11 is expressed in embryonic pancreatic epithelium during formation of islet progenitor cells that express neurogenin 3. Mice deficient for Gdf11 harbor increased numbers of NGN3+ cells,revealing that GDF11 negatively regulates production of islet progenitor cells. Despite a marked expansion of these NGN3+ islet progenitors, mice lacking Gdf11 have reduced β-cell numbers and evidence of arrested β-cell development, indicating that GDF11 is also required for β-cell maturation. Similar precursor and islet cell phenotypes are observed in mice deficient for SMAD2, an intracellular signaling factor activated by TGF-β signals. Our data suggest that Gdf11 and Smad2 regulate islet cell differentiation in parallel to the Notch pathway, which previously has been shown to control development of NGN3+ cells. Thus, our studies reveal mechanisms by which GDF11 regulates the production and maturation of islet progenitor cells in pancreas development.
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Cites
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
Dor, Y., Brown, J., Martinez, O. I., & Melton, D. A. (2004) · Nature · doi:10.1038/nature02520 · Cited by 2,219
Myostatin, a Negative Regulator of Muscle Growth, Functions by Inhibiting Myoblast Proliferation
Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J., & Kambadur, R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004356200 · Cited by 1,014
McPherron, A. C., Lawler, A. M., & Lee, S.-J. (1999) · Nature Genetics · doi:10.1038/10320 · Cited by 471
Activin receptor patterning of foregut organogenesis
Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A. (2000) · Genes & Development · doi:10.1101/gad.14.15.1866 · Cited by 212 · cited 12×
“To detect hybridization of digoxigenin-UTP (dig-UTP) labeled riboprobes to tissue sections, we used antibodies that detect dig-UTP and NBT/BCIP (blue) or INT/BCIP (rust brown, Roche, Indianapolis, IN) as previously described (Kim et al., 2000).”
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Cited by
Loffredo, F. S., Steinhauser, M. L., Jay, S. M., Gannon, J., Pancoast, J. R., Yalamanchi, P., Sinha, M., Dall’Osso, C., Khong, D., Shadrach, J. L., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.015 · Cited by 948
Bardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes & Development · doi:10.1101/gad.1478706 · Cited by 674
Regulation of muscle growth by multiple ligands signaling through activin type II receptors
Lee, S.-J., Reed, L. A., Davies, M. V., Girgenrath, S., Goad, M. E. P., Tomkinson, K. N., Wright, J. F., Barker, C., Ehrmantraut, G., Holmstrom, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505996102 · Cited by 501
Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 451
Wnt signaling regulates pancreatic β cell proliferation
Rulifson, I. C., Karnik, S. K., Heiser, P. W., ten Berge, D., Chen, H., Gu, X., Taketo, M. M., Nusse, R., Hebrok, M., & Kim, S. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701509104 · Cited by 342
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Metadata
- Authors
- Harmon, E. B., Apelqvist, A. A., Smart, N. G., Gu, X., Osborne, D. H., & Kim, S. K.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2004-12-15
- Volume
- 131
- Issue
- 24
- Pages
- 6163-6174
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2040567344
- Cited by
- 160
- References
- 4
- FWCI
- 7.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Harmon, E. B., Apelqvist, A. A., Smart, N. G., Gu, X., Osborne, D. H., & Kim, S. K. (2004). GDF11 modulates NGN3+ islet progenitor cell number and promotes β-cell differentiation in pancreas development. Development. https://doi.org/10.1242/dev.01535
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