The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Stabilization of the retinal vascular network by reciprocal feedback between blood vessels and astrocytes
Open accessAbstract
Development of the retinal vasculature is controlled by a hierarchy of interactions among retinal neurons, astrocytes and blood vessels. Retinal neurons release platelet-derived growth factor (PDGFA) to stimulate proliferation of astrocytes, which in turn stimulate blood vessel growth by secreting vascular endothelial cell growth factor (VEGF). Presumably, there must be counteractive mechanisms for limiting astrocyte proliferation and VEGF production to prevent runaway angiogenesis. Here, we present evidence that the developing vessels provide feedback signals that trigger astrocyte differentiation – marked by cessation of cell division, upregulation of glial fibrillary acidic protein (GFAP) and downregulation of VEGF. We prevented retinal vessel development by raising newborn mice in a high-oxygen atmosphere, which leads, paradoxically, to retinal hypoxia (confirmed by using the oxygen-sensing reagent EF5). The forced absence of vessels caused prolonged astrocyte proliferation and inhibited astrocyte differentiation in vivo. We could reproduce these effects by culturing retinal astrocytes in a low oxygen atmosphere, raising the possibility that blood-borne oxygen itself might induce astrocyte differentiation and indirectly prevent further elaboration of the vascular network.
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Citations
Cites
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D., et al. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302047 · Cited by 2,894
Self-citationKoch, C. J. (2002) · Methods in Enzymology · doi:10.1016/s0076-6879(02)52003-6 · Cited by 207
Fruttiger, M., Calver, A. R., & Richardson, W. D. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00757-0 · Cited by 81
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Cited by
Astrocyte dysfunction in neurological disorders: a molecular perspective
Seifert, G., Schilling, K., & Steinhäuser, C. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1870 · Cited by 799
Retinal angiogenesis in development and disease
Gariano, R. F., & Gardner, T. W. (2005) · Nature · doi:10.1038/nature04482 · Cited by 705
WANG, D., & BORDEY, A. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.015 · Cited by 502
Role and Therapeutic Potential of VEGF in the Nervous System
Ruiz de Almodovar, C., Lambrechts, D., Mazzone, M., & Carmeliet, P. (2009) · Physiological Reviews · doi:10.1152/physrev.00031.2008 · Cited by 448
Retinal vasculature development in health and disease
Selvam, S., Kumar, T., & Fruttiger, M. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.11.001 · Cited by 353
Self-citationEfficient, inducible Cre‐recombinase activation in vascular endothelium
Claxton, S., Kostourou, V., Jadeja, S., Chambon, P., Hodivala‐Dilke, K., & Fruttiger, M. (2008) · genesis · doi:10.1002/dvg.20367 · Cited by 327
Self-citationReichenbach, A., & Bringmann, A. (2020) · Glia · doi:10.1002/glia.23727 · Cited by 323
VEGF and endothelial guidance in angiogenic sprouting
Gerhardt, H. (2008) · Organogenesis · doi:10.4161/org.4.4.7414 · Cited by 318
From oxygen to erythropoietin: Relevance of hypoxia for retinal development, health and disease
Caprara, C., & Grimm, C. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.003 · Cited by 176
Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis
Stenzel, D., Lundkvist, A., Sauvaget, D., Busse, M., Graupera, M., van der Flier, A., Wijelath, E. S., Murray, J., Sobel, M., Costell, M., et al. (2011) · Development · doi:10.1242/dev.071381 · Cited by 154
Longbottom, R., Fruttiger, M., Douglas, R. H., Martinez-Barbera, J. P., Greenwood, J., & Moss, S. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902593106 · Cited by 85
Self-citationMore than meets the eye: The role of microglia in healthy and diseased retina
Murenu, E., Gerhardt, M.-J., Biel, M., & Michalakis, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1006897 · Cited by 73
Metadata
- Authors
- West, H., Richardson, W. D., & Fruttiger, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-04-15
- Volume
- 132
- Issue
- 8
- Pages
- 1855-1862
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2133375566
- Cited by
- 176
- References
- 3
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
