The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning
Abstract
The extraembryonic ectoderm (ExE) is essential for mammalian placental formation and survival of the embryo in utero. We have obtained a mouse model lacking the ExE, by targeted deletion of the transcription factor Elf5. Although Elf5 mutant embryos implant and form an ectoplacental cone, no trophoblast stem (TS) cells can be derived, indicating that the absence of ExE is a result of the lack of TS cell maintenance. Embryos without ExE tissue are able to form the anterior visceral endoderm but fail to undergo gastrulation, demonstrating an essential role for the ExE in embryonic patterning during a defined window of development.
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Cites
An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development
Saba‐El‐Leil, M. K., Vella, F. D. J., Vernay, B., Voisin, L., Chen, L., Labrecque, N., Ang, S., & Meloche, S. (2003) · The EMBO Reports · doi:10.1038/sj.embor.embor939 · Cited by 366
Galang, C. K., Muller, W. J., Foos, G., Oshima, R. G., & Hauser, C. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311887200 · Cited by 132
Cited by
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Arnold, S. J., & Robertson, E. J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2618 · Cited by 816
Maltepe, E., & Fisher, S. J. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125620 · Cited by 592
Genomic and biochemical insights into the specificity of ETS transcription factors
Hollenhorst, P. C., McIntosh, L. P., & Graves, B. J. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.79.081507.103945 · Cited by 490
Resolving early mesoderm diversification through single-cell expression profiling
Scialdone, A., Tanaka, Y., Jawaid, W., Moignard, V., Wilson, N. K., Macaulay, I. C., Marioni, J. C., & Göttgens, B. (2016) · Nature · doi:10.1038/nature18633 · Cited by 293
The Ets transcription factor Elf5 specifies mammary alveolar cell fate
Oakes, S. R., Naylor, M. J., Asselin-Labat, M.-L., Blazek, K. D., Gardiner-Garden, M., Hilton, H. N., Kazlauskas, M., Pritchard, M. A., Chodosh, L. A., Pfeffer, P. L., et al. (2008) · Genes & Development · doi:10.1101/gad.1614608 · Cited by 260
Self-citationEpigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer
Smith, Z. D., Shi, J., Gu, H., Donaghey, J., Clement, K., Cacchiarelli, D., Gnirke, A., Michor, F., & Meissner, A. (2017) · Nature · doi:10.1038/nature23891 · Cited by 201
Hemberger, M., Udayashankar, R., Tesar, P., Moore, H., & Burton, G. J. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq128 · Cited by 181
Choi, Y. S., & Sinha, S. (2006) · Biochemical Journal · doi:10.1042/bj20060375 · Cited by 32
Metadata
- Authors
- Donnison, M., Beaton, A., Davey, H. W., Broadhurst, R., L'Huillier, P., & Pfeffer, P. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-05-15
- Volume
- 132
- Issue
- 10
- Pages
- 2299-2308
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2131586796
- Cited by
- 213
- References
- 2
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
