The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mind bomb 1 is essential for generating functional Notch ligands to activate Notch
Abstract
The Delta-Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for cell fate specification. Mind bomb 1 (Mib1) has been identified as a ubiquitin ligase that promotes the endocytosis of Delta. We now report that mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis,vasculogenesis and cardiogenesis. The Mib1–/–embryos exhibit reduced expression of Notch target genes Hes5, Hey1, Hey2 and Heyl, with the loss of N1icd generation. Interestingly, in the Mib1–/–mutants, Dll1 accumulated in the plasma membrane, while it was localized in the cytoplasm near the nucleus in the wild types, indicating that Mib1 is essential for the endocytosis of Notch ligand. In accordance with the pan-Notch defects in Mib1–/– embryos, Mib1 interacts with and regulates all of the Notch ligands, jagged 1 and jagged 2,as well as Dll1, Dll3 and Dll4. Our results show that Mib1 is an essential regulator, but not a potentiator, for generating functional Notch ligands to activate Notch signaling.
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Cites
Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex
De Strooper, B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00205-8 · Cited by 965
Gale, N. W., Dominguez, M. G., Noguera, I., Pan, L., Hughes, V., Valenzuela, D. M., Murphy, A. J., Adams, N. C., Lin, H. C., Holash, J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407290101 · Cited by 600
Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
Shi, S., & Stanley, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831126100 · Cited by 381
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Dejana, E., Tournier-Lasserve, E., & Weinstein, B. M. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.004 · Cited by 788
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MicroRNA miR-137 Regulates Neuronal Maturation by Targeting Ubiquitin Ligase Mind Bomb-1
Smrt, R. D., Szulwach, K. E., Pfeiffer, R. L., Li, X., Guo, W., Pathania, M., Teng, Z.-Q., Luo, Y., Peng, J., Bordey, A., et al. (2010) · Stem Cells · doi:10.1002/stem.431 · Cited by 404
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Koch, U., Lehal, R., & Radtke, F. (2013) · Development · doi:10.1242/dev.080614 · Cited by 283
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MacGurn, J. A., Hsu, P.-C., & Emr, S. D. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060210-093619 · Cited by 287
Structural requirements for activity of Mind bomb1 in Notch signaling
Cao, R., Gozlan, O., Airich, A., Tveriakhina, L., Zhou, H., Jiang, H., Cole, P. A., Aster, J. C., Klein, T., Sprinzak, D., et al. (2024) · Structure · doi:10.1016/j.str.2024.07.011 · Cited by 7
Metadata
- Authors
- Koo, B.-K., Lim, H.-S., Song, R., Yoon, M.-J., Yoon, K.-J., Moon, J.-S., Kim, Y.-W., Kwon, M.-C., Yoo, K.-W., Kong, M.-P., Lee, J., Chitnis, A. B., Kim, C.-H., & Kong, Y.-Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-08-01
- Volume
- 132
- Issue
- 15
- Pages
- 3459-3470
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2119309845
- Cited by
- 247
- References
- 3
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
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