The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/β-catenin, Activin/Nodal and BMP signaling
Abstract
The canonical Wnt/β-catenin signaling has remarkably diverse roles in embryonic development, stem cell self-renewal and cancer progression. Here, we show that stabilized expression of β-catenin perturbed human embryonic stem (hES)-cell self-renewal, such that up to 80% of the hES cells developed into the primitive streak (PS)/mesoderm progenitors, reminiscent of early mammalian embryogenesis. The formation of the PS/mesoderm progenitors essentially depended on the cooperative action of β-catenin together with Activin/Nodal and BMP signaling pathways. Intriguingly, blockade of BMP signaling completely abolished mesoderm generation, and induced a cell fate change towards the anterior PS progenitors. The PI3-kinase/Akt, but not MAPK,signaling pathway had a crucial role in the anterior PS specification, at least in part, by enhancing β-catenin stability. In addition,Activin/Nodal and Wnt/β-catenin signaling synergistically induced the generation and specification of the anterior PS/endoderm. Taken together, our findings clearly demonstrate that the orchestrated balance of Activin/Nodal and BMP signaling defines the cell fate of the nascent PS induced by canonical Wnt/β-catenin signaling in hES cells.
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WNT and β-catenin signalling: diseases and therapies
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Depletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells
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Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation
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Guo, X., & Wang, X.-F. (2009) · Cell Research · doi:10.1038/cr.2008.302 · Cited by 1,015
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“Its emergence is accompanied by the activation of the transcription factor Brachyury (T), which marks the onset of gastrulation [2, 11, 20].”
Background
Metadata
- Authors
- Sumi, T., Tsuneyoshi, N., Nakatsuji, N., & Suemori, H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2008-09-01
- Volume
- 135
- Issue
- 17
- Pages
- 2969-2979
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2170441682
- Cited by
- 327
- References
- 6
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/β-catenin, Activin/Nodal and BMP signaling. https://app.cochat.ai/papers/10.1242/dev.021121
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- Sumi, T., Tsuneyoshi, N., Nakatsuji, N., & Suemori, H. (2008). Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/β-catenin, Activin/Nodal and BMP signaling. Development. https://doi.org/10.1242/dev.021121
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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