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Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production
Open accessAbstract
Development of the vertebrate gut is controlled by paracrine crosstalk between the endodermal epithelium and the associated splanchnic mesoderm. In the adult, the same types of signals control epithelial proliferation and survival, which account for the importance of the stroma in colon carcinoma progression. Here, we show that targeting murine Foxf1 and Foxf2, encoding forkhead transcription factors, has pleiotropic effects on intestinal paracrine signaling. Inactivation of both Foxf2alleles, or one allele each of Foxf1 and Foxf2, cause a range of defects, including megacolon, colorectal muscle hypoplasia and agangliosis. Foxf expression in the splanchnic mesoderm is activated by Indian and sonic hedgehog secreted by the epithelium. In Foxf mutants, mesenchymal expression of Bmp4 is reduced, whereas Wnt5a expression is increased. Activation of the canonical Wnt pathway – with nuclear localization of β-catenin in epithelial cells – is associated with over-proliferation and resistance to apoptosis. Extracellular matrix,particularly collagens, is severely reduced in Foxf mutant intestine, which causes epithelial depolarization and tissue disintegration. Thus, Foxf proteins are mesenchymal factors that control epithelial proliferation and survival, and link hedgehog to Bmp and Wnt signaling.
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Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401
Mahlapuu, M., Ormestad, M., Enerbäck, S., & Carlsson, P. (2001) · Development · doi:10.1242/dev.128.2.155 · Cited by 332
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De Wever, O., Demetter, P., Mareel, M., & Bracke, M. (2008) · International Journal of Cancer · doi:10.1002/ijc.23925 · Cited by 722
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Benayoun, B. A., Caburet, S., & Veitia, R. A. (2011) · Trends in Genetics · doi:10.1016/j.tig.2011.03.003 · Cited by 301
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Le Guen, L., Marchal, S., Faure, S., & de Santa Barbara, P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1975-2 · Cited by 95
Liu, L., Chen, G., Chen, T., Shi, W., Hu, H., Song, K., Huang, R., Cai, H., & He, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01990-3 · Cited by 68
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Khoueiry, P., Girardot, C., Ciglar, L., Peng, P.-C., Gustafson, E. H., Sinha, S., & Furlong, E. E. (2017) · eLife · doi:10.7554/elife.28440 · Cited by 44
StabMap: Mosaic single cell data integration using non-overlapping features
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Metadata
- Authors
- Ormestad, M., Astorga, J., Landgren, H., Wang, T., Johansson, B. R., Miura, N., & Carlsson, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-03-01
- Volume
- 133
- Issue
- 5
- Pages
- 833-843
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2123445833
- Cited by
- 245
- References
- 2
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- green
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