The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Wnt/β-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis
Open accessAbstract
Canonical Wnt/β-catenin signaling regulates the activation of the myogenic determination gene Myf5 at the onset of myogenesis, but the underlying molecular mechanism is unknown. Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz)receptors (Fz1 and/or Fz6), through the canonical β-catenin pathway, in the epaxial domain of newly formed somites. We show that Myf5activation is dramatically reduced by blocking the Wnt/β-catenin pathway in somite progenitor cells, whereas expression of activated β-catenin is sufficient to activate Myf5 in somites but not in the presomitic mesoderm. In addition, we identified Tcf/Lef sequences immediately 5′ to the Myf5 early epaxial enhancer. These sites determine the correct spatiotemporal expression of Myf5 in the epaxial domain of the somite, mediating the synergistic action of the Wnt/β-catenin and the Shh/Gli pathways. Taken together, these results demonstrate that Myf5is a direct target of Wnt/β-catenin, and that its full activation requires a cooperative interaction between the canonical Wnt and the Shh/Gli pathways in muscle progenitor cells.
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Cites
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159
Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801
Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins
Chen, A. E., Ginty, D. D., & Fan, C.-M. (2005) · Nature · doi:10.1038/nature03126 · Cited by 309
Dorsky, R. I., Sheldahl, L. C., & Moon, R. T. (2002) · Developmental Biology · doi:10.1006/dbio.2001.0515 · Cited by 287 · cited 2×
“The role of the Wnt pathway in cell fate determination was demonstrated for neural crest cells (Brault et al., 2001; Dorsky et al., 2002) and for hematopoietic cells, for which a role in proliferation and stem cell self-renewal was also reported (Austin et al., 1997; Brandon et al., 2000; Reya et…”
BackgroundBillin, A. N., Thirlwell, H., & Ayer, D. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.18.6882-6890.2000 · Cited by 216
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Building Muscle: Molecular Regulation of Myogenesis
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Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
Braun, T., & Gautel, M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3118 · Cited by 713
von Maltzahn, J., Chang, N. C., Bentzinger, C. F., & Rudnicki, M. A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.07.008 · Cited by 393
Hutcheson, D. A., Zhao, J., Merrell, A., Haldar, M., & Kardon, G. (2009) · Genes & Development · doi:10.1101/gad.1769009 · Cited by 301
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Bryson-Richardson, R. J., & Currie, P. D. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2369 · Cited by 291
The extracellular matrix dimension of skeletal muscle development
Thorsteinsdóttir, S., Deries, M., Cachaço, A. S., & Bajanca, F. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.03.015 · Cited by 167
Wnt signaling in bone and muscle
Rudnicki, M. A., & Williams, B. O. (2015) · Bone · doi:10.1016/j.bone.2015.02.009 · Cited by 132
Secreted ADAMTS-like 2 promotes myoblast differentiation by potentiating WNT signaling
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Metadata
- Authors
- Borello, U., Berarducci, B., Murphy, P., Bajard, L., Buffa, V., Piccolo, S., Buckingham, M., & Cossu, G.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-09-15
- Volume
- 133
- Issue
- 18
- Pages
- 3723-3732
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1988197137
- Cited by
- 183
- References
- 6
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- green
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