The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
How is pluripotency determined and maintained?
Abstract
Mouse embryonic stem (ES) cells are pluripotent, as they have the ability to differentiate into the various cell types of a vertebrate embryo. Pluripotency is a property of the inner cell mass (ICM), from which mouse ES cells are derived, and of the epiblast of the blastocyst. Recent extensive molecular studies of mouse ES cells have revealed the unique molecular mechanisms that govern pluripotency. These studies show that ES cells continue to self-renew because of a self-organizing network of transcription factors that prevents their differentiation and promotes their proliferation, and because of epigenetic processes that might be under the control of the pluripotent transcription factor network.
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Cites
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Cited by
Shen, X., Liu, Y., Hsu, Y.-J., Fujiwara, Y., Kim, J., Mao, X., Yuan, G.-C., & Orkin, S. H. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.016 · Cited by 1,021
A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells
Niwa, H., Ogawa, K., Shimosato, D., & Adachi, K. (2009) · Nature · doi:10.1038/nature08113 · Cited by 872
Self-citationAn Oct4-Centered Protein Interaction Network in Embryonic Stem Cells
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Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
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Zscan4 regulates telomere elongation and genomic stability in ES cells
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Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
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Obokata, H., Sasai, Y., Niwa, H., Kadota, M., Andrabi, M., Takata, N., Tokoro, M., Terashita, Y., Yonemura, S., Vacanti, C. A., et al. (2014) · Nature · doi:10.1038/nature13599 · Cited by 313
Self-citationRetractedDirect lineage conversions: unnatural but useful?
Vierbuchen, T., & Wernig, M. (2011) · Nature Biotechnology · doi:10.1038/nbt.1946 · Cited by 259
Reynolds, N., Latos, P., Hynes-Allen, A., Loos, R., Leaford, D., O'Shaughnessy, A., Mosaku, O., Signolet, J., Brennecke, P., Kalkan, T., et al. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.02.020 · Cited by 236
“to Promote Transcriptional Heterogeneity and Lineage Commitment”
BackgroundRoles of the Polycomb group proteins in stem cells and cancer
Richly, H., Aloia, L., & Di Croce, L. (2011) · Cell Death & Disease · doi:10.1038/cddis.2011.84 · Cited by 218
SOX2 Regulates YAP1 to Maintain Stemness and Determine Cell Fate in the Osteo-Adipo Lineage
Seo, E., Basu-Roy, U., Gunaratne, P. H., Coarfa, C., Lim, D.-S., Basilico, C., & Mansukhani, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.029 · Cited by 216
“SOX2 is a member of the HMG-domain family and is a pluripotency transcription factor that is required to maintain the stemness and self-renewal of embryonic stem cells (ESCs) (Niwa, 2007).”
BackgroundTransposable elements in the mammalian embryo: pioneers surviving through stealth and service
Gerdes, P., Richardson, S. R., Mager, D. L., & Faulkner, G. J. (2016) · Genome Biology · doi:10.1186/s13059-016-0965-5 · Cited by 156
Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts
Tsubooka, N., Ichisaka, T., Okita, K., Takahashi, K., Nakagawa, M., & Yamanaka, S. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01301.x · Cited by 154
Miller, A., Ralser, M., Kloet, S. L., Loos, R., Nishinakamura, R., Bertone, P., Vermeulen, M., & Hendrich, B. (2016) · Development · doi:10.1242/dev.139113 · Cited by 78
“It is clear from a large number of studies that the coordinated action of multiple transcription factors and chromatin-modifying proteins is essential to maintain the delicate balance between self-renewal and differentiation of ESCs (Morey et al., 2015; Niwa, 2007; Signolet and Hendrich, 2015).”
BackgroundARID3A is required for mammalian placenta development
Rhee, C., Edwards, M., Dang, C., Harris, J., Brown, M., Kim, J., & Tucker, H. O. (2017) · Developmental Biology · doi:10.1016/j.ydbio.2016.12.003 · Cited by 42
Metadata
- Authors
- Niwa, H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-02-15
- Volume
- 134
- Issue
- 4
- Pages
- 635-646
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2065746091
- Cited by
- 783
- References
- 10
- FWCI
- 27.90
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
