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Transcriptional control of stem cell maintenance in the Drosophila intestine
Open accessAbstract
Adult stem cells maintain tissue homeostasis by controlling the proper balance of stem cell self-renewal and differentiation. The adult midgut of Drosophila contains multipotent intestinal stem cells (ISCs) that self-renew and produce differentiated progeny. Control of ISC identity and maintenance is poorly understood. Here we find that transcriptional repression of Notch target genes by a Hairless-Suppressor of Hairless complex is required for ISC maintenance, and identify genes of the Enhancer of split complex [E(spl)-C] as the major targets of this repression. In addition, we find that the bHLH transcription factor Daughterless is essential to maintain ISC identity and that bHLH binding sites promote ISC-specific enhancer activity. We propose that Daughterless-dependent bHLH activity is important for the ISC fate and that E(spl)-C factors inhibit this activity to promote differentiation.
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Citations
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Andersson, E. R., Sandberg, R., & Lendahl, U. (2011) · Development · doi:10.1242/dev.063610 · Cited by 950
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Maintaining Tissue Homeostasis: Dynamic Control of Somatic Stem Cell Activity
Biteau, B., Hochmuth, C. E., & Jasper, H. (2011) · Cell Stem Cell · doi:10.1016/j.stem.2011.10.004 · Cited by 314
Shaw, R. L., Kohlmaier, A., Polesello, C., Veelken, C., Edgar, B. A., & Tapon, N. (2010) · Development · doi:10.1242/dev.052506 · Cited by 307
Stem cells living with a Notch
Koch, U., Lehal, R., & Radtke, F. (2013) · Development · doi:10.1242/dev.080614 · Cited by 283
A cell atlas of the adult Drosophila midgut
Hung, R.-J., Hu, Y., Kirchner, R., Liu, Y., Xu, C., Comjean, A., Tattikota, S. G., Li, F., Song, W., Ho Sui, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916820117 · Cited by 282
Dutta, D., Dobson, A. J., Houtz, P. L., Gläßer, C., Revah, J., Korzelius, J., Patel, P. H., Edgar, B. A., & Buchon, N. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.009 · Cited by 254
Stem cells and lineages of the intestine: a developmental and evolutionary perspective
Takashima, S., Gold, D., & Hartenstein, V. (2013) · Development Genes and Evolution · doi:10.1007/s00427-012-0422-8 · Cited by 67
Miller, D. E., Kahsai, L., Buddika, K., Dixon, M. J., Kim, B. Y., Calvi, B. R., Sokol, N. S., Hawley, R. S., & Cook, K. R. (2020) · G3 Genes|Genomes|Genetics · doi:10.1534/g3.120.401559 · Cited by 16
Metadata
- Authors
- Bardin, A. J., Perdigoto, C. N., Southall, T. D., Brand, A. H., & Schweisguth, F.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2010-03-01
- Volume
- 137
- Issue
- 5
- Pages
- 705-714
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1977646726
- Cited by
- 184
- References
- 0
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- green
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