The spatiotemporal development of adipose tissue
Open accessAbstract
Adipose tissue is a structure highly specialized in energy storage. The adipocyte is the parenchymal component of adipose tissue and is known to be mesoderm or neuroectoderm in origin; however, adipocyte development remains poorly understood. Here, we investigated the development of adipose tissue by analyzing postnatal epididymal adipose tissue (EAT) in mouse. EAT was found to be generated from non-adipose structure during the first 14 postnatal days. From postnatal day 1 (P1) to P4, EAT is composed of multipotent progenitor cells that lack adipogenic differentiation capacity in vitro, and can be regarded as being in the ‘undetermined’ state. However, the progenitor cells isolated from P4 EAT obtain their adipogenic differentiation capacity by physical interaction generated by cell-to-matrix and cell-to-cell contact both in vitro and in vivo. In addition, we show that impaired angiogenesis caused by either VEGFA blockade or macrophage depletion in postnatal mice interferes with adipose tissue development. We conclude that appropriate interaction between the cellular and matrix components along with proper angiogenesis are mandatory for the development of adipose tissue.
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Mice and rats are born without WAT, which develops in the first 14 days post birth from progenitor cells in non-adipocyte structures.
“However, mice and rats are born without WAT, which develops in the first 14 days post birth from progenitor cells in non-adipocyte structures [44].”
From Developmental programming of offspring adipose tissue biology and obesity risk (2021) · cites this paper as [44]
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- Authors
- Han, J., Lee, J.-E., Jin, J., Lim, J. S., Oh, N., Kim, K., Chang, S.-I., Shibuya, M., Kim, H., & Koh, G. Y.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 305-701, Korea.
- Tokyo Medical and Dental University (JP)
- Corresponding author
- Koh, Gou Young
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2011-11-15
- Volume
- 138
- Issue
- 22
- Pages
- 5027-5037
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2136307424
- Cited by
- 212
- References
- 8
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 19 · 2023: 13 · 2022: 18 · 2021: 18 · 2020: 19 · 2019: 15 · 2018: 10 · 2017: 12 · 2016: 10 · 2015: 15 · 2014: 12 · 2013: 17 · 2012: 8
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- Ministry of Education, Science and Technology
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipose tissue development, epididymal adipose tissue, adipogenesis, cell-matrix interactions, cell-cell contact, angiogenesis, VEGF-A, macrophages, postnatal development, energy storage
- MeSH terms
- Adipose Tissue, Animals, Animals, Newborn, Cell Differentiation, Cells, Cultured, Epididymis, Male, Mice, Inbred C57BL, Models, Biological, Stem Cells, Time Factors, Mice, Knockout, Gene Expression Regulation, Developmental, 3T3-L1 Cells, Body Fat Distribution, Mice, Mesenchymal Stem Cells
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