Angiogenesis modulates adipogenesis and obesity
Open accessAbstract
Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.
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The newly formed vascular network is crucial for adipogenesis and adipose tissue expansion.
“The newly formed vascular network is crucial for adipogenesis and AT expansion (64,65).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [64]
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- Authors
- Cao, Y.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Cao, Yihai
- ORCID
- Cao, Yihai
- Venue
- Journal of Clinical Investigation
- Published
- 2007-09-04
- Volume
- 117
- Issue
- 9
- Pages
- 2362-2368
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1963348
- OpenAlex
- W2027442301
- Cited by
- 736
- References
- 120
- Citations by year
- 2026: 18 · 2025: 18 · 2024: 24 · 2023: 32 · 2022: 32 · 2021: 25 · 2020: 43 · 2019: 47 · 2018: 59 · 2017: 48 · 2016: 40 · 2015: 42 · 2014: 66 · 2013: 67 · 2012: 43
- FWCI
- 21.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Swedish Cancer Foundation
- European Commission
- Hjärt-Lungfonden
- Karolinska Institutet
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- angiogenesis, adipogenesis, obesity, neovascularization, adipocytes, angiogenic factors, leptin, vascular endothelial growth factor, angiopoietins, paracrine signaling, anti-angiogenic therapy
- MeSH terms
- Animals, Cell Communication, Humans, Neovascularization, Pathologic, Obesity, Adipocytes, Endothelial Cells, Angiogenesis Inducing Agents, Adipogenesis
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