Cited by 736Adipokines, Inflammation, and Metabolic DiseasesAngiogenesis and VEGF in CancerAdipose Tissue and Metabolism

Angiogenesis modulates adipogenesis and obesity

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Cao, Yihai·2007·Journal of Clinical Investigation

Abstract

Substantial evidence shows that neoplastic and nonneoplastic tissue growth is dependent on angiogenesis. Neovascularization and adipogenesis are temporally and spatially coupled processes during prenatal life and they continue to reciprocally interact via paracrine signaling systems throughout adult life. Activated adipocytes produce multiple angiogenic factors including leptin, angiopoietins, HGF, GM-CSF, VEGF, FGF-2, and TGF-beta, which either alone or collectively stimulate neovascularization during fat mass expansion. Thus antiangiogenic agents provide a novel therapeutic option for prevention and treatment of human obesity and its related disorders.

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  • The newly formed vascular network is crucial for adipogenesis and adipose tissue expansion.

    “The newly formed vascular network is crucial for adipogenesis and AT expansion (64,65).”

    From Adipose tissue remodeling and obesity (2011) · cites this paper as [64]

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Authors
Cao, Y.
Affiliations
Karolinska Institutet (SE)
Corresponding author
Cao, Yihai
Venue
Journal of Clinical Investigation
Published
2007-09-04
Volume
117
Issue
9
Pages
2362-2368
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2027442301
Cited by
736
References
120
Citations by year
2026: 18 · 2025: 18 · 2024: 24 · 2023: 32 · 2022: 32 · 2021: 25 · 2020: 43 · 2019: 47 · 2018: 59 · 2017: 48 · 2016: 40 · 2015: 42 · 2014: 66 · 2013: 67 · 2012: 43
FWCI
21.41
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Swedish Cancer Foundation
  • European Commission
  • Hjärt-Lungfonden
  • Karolinska Institutet
  • Vetenskapsrådet
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
angiogenesis, adipogenesis, obesity, neovascularization, adipocytes, angiogenic factors, leptin, vascular endothelial growth factor, angiopoietins, paracrine signaling, anti-angiogenic therapy
MeSH terms
Animals, Cell Communication, Humans, Neovascularization, Pathologic, Obesity, Adipocytes, Endothelial Cells, Angiogenesis Inducing Agents, Adipogenesis

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