The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Switching on cilia: transcriptional networks regulating ciliogenesis
Open accessAbstract
Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory hubs for a variety of signal transduction pathways. Despite having a conserved basic morphology, cilia vary extensively in their shapes and sizes, ultrastructural details, numbers per cell, motility patterns and sensory capabilities. Emerging evidence indicates that this diversity, which is intimately linked to the different functions that cilia perform, is in large part programmed at the transcriptional level. Here, we review our understanding of the transcriptional control of ciliary biogenesis, highlighting the activities of FOXJ1 and the RFX family of transcriptional regulators. In addition, we examine how a number of signaling pathways, and lineage and cell fate determinants can induce and modulate ciliogenic programs to bring about the differentiation of distinct cilia types.
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Cites
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“…suggesting that besides playing an essential role in promoting ciliogenesis, the RFX factors could also be directly involved in the specification of the ciliated cell types (Burghoorn et al., 2012; Efimenko et al., 2005; Zhang et al., 2006), a hypothesis that clearly requires further exploration.”
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Primary cilia promote the differentiation of human neurons through the WNT signaling pathway
Coschiera, A., Yoshihara, M., Lauter, G., Ezer, S., Pucci, M., Li, H., Kavšek, A., Riedel, C. G., Kere, J., & Swoboda, P. (2024) · BMC Biology · doi:10.1186/s12915-024-01845-w · Cited by 26
Self-citationJulien, L., Chassagne, J., Peccate, C., Lorain, S., Piétri-Rouxel, F., Danos, O., & Benkhelifa-Ziyyat, S. (2018) · Scientific Reports · doi:10.1038/s41598-017-18604-3 · Cited by 13
Metadata
- Authors
- Choksi, S. P., Lauter, G., Swoboda, P., & Roy, S.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2014-04-01
- Volume
- 141
- Issue
- 7
- Pages
- 1427-1441
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2138069365
- Cited by
- 358
- References
- 6
- FWCI
- 18.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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