The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
Abstract
Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Close cooperation between this trio is necessary for ensuring orderly progression through the cell cycle. In addition to their well-established function in cell cycle control, it is becoming increasingly apparent that mammalian Cdks, cyclins and CKIs play indispensable roles in processes such as transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions and spermatogenesis. Even more remarkably, they can accomplish some of these tasks individually, without the need for Cdk/cyclin complex formation or kinase activity. In this Review, we discuss the latest revelations about Cdks, cyclins and CKIs with the goal of showcasing their functional diversity beyond cell cycle regulation and their impact on development and disease in mammals.
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Citations
Cites
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Cited by
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Molecular targeted therapy for anticancer treatment
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Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia
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CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought
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FOXO transcription factor family in cancer and metastasis
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Metadata
- Authors
- Lim, S., & Kaldis, P.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2013-08-01
- Volume
- 140
- Issue
- 15
- Pages
- 3079-3093
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1985139403
- Cited by
- 1,487
- References
- 15
- FWCI
- 41.58
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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