The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads
Abstract
The role of the human Y chromosome in the etiology of gonadoblastoma, a gonadal neoplasm, is considered and a two-part model is presented. According to this hypothesis: (1) There is a gene on the Y chromosome that strongly predisposes dysgenetic gonads to develop gonadoblastomas (Page, 1986) and (2) this postulated GBY gene (GonadoBlastoma locus on Y chromosome) has some physiological function in normal males. GBY may, for example, function in or prior to spermatogenesis in normal testes. Y-DNA hybridization analysis of individuals with gonadoblastoma and partial deletions of the Y chromosome should be of use in testing this proposal. To date, such studies suggest that GBY maps to the region that includes deletion intervals 4B to 7, i.e. it is located near the centromere or on the long arm of the Y chromosome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Detection of specific sequences among DNA fragments separated by gel electrophoresis
Southern, E. M. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80083-0 · Cited by 32,249
Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
Downward, J., Yarden, Y., Mayes, E., Scrace, G., Totty, N., Stockwell, P., Ullrich, A., Schlessinger, J., & Waterfield, M. D. (1984) · Nature · doi:10.1038/307521a0 · Cited by 2,516
Waterfield, M. D., Scrace, G. T., Whittle, N., Stroobant, P., Johnsson, A., Wasteson, Å., Westermark, B., Heldin, C.-H., Huang, J. S., & Deuel, T. F. (1983) · Nature · doi:10.1038/304035a0 · Cited by 1,616
Doolittle, R. F., Hunkapiller, M. W., Hood, L. E., Devare, S. G., Robbins, K. C., Aaronson, S. A., & Antoniades, H. N. (1983) · Science · doi:10.1126/science.6304883 · Cited by 1,536
Tiepolo, L., & Zuffardi, O. (1976) · Human Genetics · doi:10.1007/bf00278879 · Cited by 1,059
Gonadoblastoma.A review of 74 cases
Scully, R. E. (1970) · Cancer · doi:10.1002/1097-0142(197006)25:6<1340::aid-cncr2820250612>3.0.co;2-n · Cited by 646
Cloning of human satellite III DNA: different components are on different chromosomes
Cooke, H. J., & Hindley, J. (1979) · Nucleic Acids Research · doi:10.1093/nar/6.10.3177 · Cited by 460
The age of occurrence of gonadal tumors in intersex patients with a Y chromosome
Manuel, M., Katayama, K. P., & Jones, H. W. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90160-5 · Cited by 453
Abnormal sexual differentiation and neoplasia
Verp, M. S., & Simpson, J. L. (1987) · Cancer Genetics and Cytogenetics · doi:10.1016/0165-4608(87)90180-4 · Cited by 422
Spermatogenic failure in male mice lacking H–Y antigen
Burgoyne, P. S., Levy, E. R., & McLaren, A. L. D. (1986) · Nature · doi:10.1038/320170a0 · Cited by 142
A Deletion Map of the Human Y Chromosome Based on DNA Hybridization
Vergnaud, G., Page, D. C., Simmler, M., Brown, L. G., Rouyer, F., NOEL, B., Botstein, D., de la Chapelle, A., & Weissenbach, J. (1986) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198610000-00015 · Cited by 140
Self-citationSmall deletions of the short arm of the Y chromosome in 46,XY females.
Distèche, C. M., Casanova, M., Saal, H. M., Friedman, C. L., Sybert, V. P., Graham, J. M., Thuline, H. C., Page, D. C., & Fellous, M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.20.7841 · Cited by 139
Self-citationSimpson, E., Chandler, P., Goulmy, E., Distèche, C. M., Ferguson-Smith, M. A., & Page, D. C. (1987) · Nature · doi:10.1038/326876a0 · Cited by 126
Self-citationH-Y antigen, serologically detectable male antigen and sex determination
Silvers, W. K., Gasser, D. L., & Eicher, E. M. (1982) · Cell · doi:10.1016/0092-8674(82)90197-0 · Cited by 124
Sex Reversal: Deletion Mapping the Male-determining Function of the Human Y ChromosomePreprint
Page, D. C. (1986) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1986.051.01.028 · Cited by 98
Self-citationMüller, U., Donlon, T. A., Schmid, M., Fitch, N., Richer, C., Lalande, M., & Latt, S. A. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.16.6489 · Cited by 95
Tooth sizes in two males with deletions of the long arm of the Y‐chromosome
Alvesalo, L. J., & de la Chapelle, A. (1981) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1981.tb00305.x · Cited by 68
Magenis, R. E., Tochen, M. L., Holahan, K. P., Carey, T. C., Allen, L., & Brown, M. G. (1984) · The Journal of Pediatrics · doi:10.1016/s0022-3476(84)80077-3 · Cited by 53
Cited by
Germ Cell Tumors in the Intersex Gonad: Old Paths, New Directions, Moving Frontiers
Cools, M., Drop, S. L. S., Wolffenbuttel, K. P., Oosterhuis, J. W., & Looijenga, L. H. J. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0005 · Cited by 555
Jobling, M. A., & Tyler-Smith, C. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(00)02057-6 · Cited by 82
Metadata
- Authors
- Page, D. C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1987-03-01
- Volume
- 101
- Issue
- Supplement
- Pages
- 151-156
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1949453496
- Cited by
- 271
- References
- 18
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
