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Transcripts of α-cardiac and α-skeletal actins are early markers for myogenesis in the mouse embryo
Abstract
Among the first tissues to differentiate in the mammalian embryo are cardiac and subsequently skeletal striated muscle. We have developed specific cRNA probes corresponding to the 5′ noncoding regions of α-cardiac and α-skeletal actin mRNAs in order to investigate myogenesis in the mouse embryo. Transcripts coding for cardiac actin which is the major isoform of the adult heart can first be detected between 7·5 and 7·8 days p.c. in the developing heart and are observed in all somites as they are formed. In addition, α-skeletal actin transcripts are accumulated at much lower levels in cardiac tissue and newly formed somites; both heart and skeletal muscle show co expression of this actin gene pair at all stages of development examined. The fact that cardiac actin transcripts can be observed in the myotomal portion of the somite prior to muscle fibre differentiation indicates that cardiac actin transcripts (and to a lesser extent skeletal actin transcripts) are markers not only of striated muscle tissue, but also of earlier stages of the myogenic programme in vivo.
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Cited by
Claycomb, W. C., Lanson, N. A., Stallworth, B. S., Egeland, D. B., Delcarpio, J. B., Bahinski, A., & Izzo, N. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2979 · Cited by 1,546
The Arterial Pole of the Mouse Heart Forms from Fgf10-Expressing Cells in Pharyngeal Mesoderm
Kelly, R. G., Brown, N. A., & Buckingham, M. E. (2001) · Developmental Cell · doi:10.1016/s1534-5807(01)00040-5 · Cited by 853
Self-citationRole of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum
de la Pompa, J. L., Timmerman, L. A., Takimoto, H., Yoshida, H., Elia, A. J., Samper, E., Potter, J., Wakeham, A., Marengere, L., Langille, B. L., et al. (1998) · Nature · doi:10.1038/32419 · Cited by 660
Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.
Mitchell, P. J., Timmons, P. M., Hébert, J. M., Rigby, P. W., & Tjian, R. (1991) · Genes & Development · doi:10.1101/gad.5.1.105 · Cited by 593
Ott, M.-O., Bober, E., Lyons, G., Arnold, H., & Buckingham, M. (1991) · Development · doi:10.1242/dev.111.4.1097 · Cited by 561
Self-citationKurima, K., Peters, L. M., Yang, Y., Riazuddin, S., Ahmed, Z. M., Naz, S., Arnaud, D., Drury, S., Mo, J., Makishima, T., et al. (2002) · Nature Genetics · doi:10.1038/ng842 · Cited by 473
TWEAK induces liver progenitor cell proliferation
Jakubowski, A., Ambrose, C., Parr, M., Lincecum, J. M., Wang, M. Z., Zheng, T. S., Browning, B., Michaelson, J. S., Baestcher, M., Wang, B., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23486 · Cited by 419
Developmental regulation of myosin gene expression in mouse cardiac muscle.
Lyons, G. E., Schiaffino, S., Sassoon, D., Barton, P., & Buckingham, M. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.6.2427 · Cited by 414
Self-citationReturn to the fetal gene program: A suggested metabolic link to gene expression in the heart
Taegtmeyer, H., Sen, S., & Vela, D. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05100.x · Cited by 411
Identification of skeletal muscle precursor cells in vivo by use of MyoD1 and myogenin probes
Grounds, M. D., Garrett, K. L., Lai, M. C., Wright, W. E., & Beilharz, M. W. (1992) · Cell & Tissue Research · doi:10.1007/bf00318695 · Cited by 313
Cserjesi, P., Lilly, B., Bryson, L., Wang, Y., Sassoon, D. A., & Olson, E. N. (1992) · Development · doi:10.1242/dev.115.4.1087 · Cited by 289
Self-citationThe expression of myosin genes in developing skeletal muscle in the mouse embryo.
Lyons, G. E., Ontell, M., Cox, R., Sassoon, D., & Buckingham, M. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.4.1465 · Cited by 270
Self-citationZhu, W.-Z., Xie, Y., Moyes, K. W., Gold, J. D., Askari, B., & Laflamme, M. A. (2010) · Circulation Research · doi:10.1161/circresaha.110.223917 · Cited by 228
Metadata
- Authors
- Sassoon, D. A., Garner, I., & Buckingham, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1988-09-01
- Volume
- 104
- Issue
- 1
- Pages
- 155-164
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2416501904
- Cited by
- 325
- References
- 0
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- closed
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