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Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside.
Open accessAbstract
We have generated a hybridoma cell line secreting a monoclonal antibody that specifically binds to the surfaces of oligodendrocytes and Schwann cells, the cells involved in myelin formation in the central and peripheral nervous systems, respectively. Binding studies using purified sphingolipids showed that this antibody reacts strongly with galactocerebroside (GalC), the major galactosphingolipid of myelin. The antibody was used in conjunction with rabbit antisera against sulfatide, the sulfated form of GalC, to examine the developmental appearance of these lipids on the surfaces of oligodendrocytes and Schwann cells. In addition, the loss of GalC and sulfatide from freshly dissociated Schwann cells was compared. These studied showed that GalC is expressed on the cell surface prior to sulfatide on both of these cell types in vivo and in vitro. Conversely, dissociated Schwann cells lose their cell surface sulfatide more rapidly than they lose their surface GalC under nonmyelinating conditions.
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Citations
Cited by
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828
Cell death and control of cell survival in the oligodendrocyte lineage
Barres, B. A., Hart, I. K., Coles, H. S. R., Burne, J. F., Voyvodic, J. T., Richardson, W. D., & Raff, M. C. (1992) · Cell · doi:10.1016/0092-8674(92)90531-g · Cited by 1,345
Noble, M., Murray, K., Stroobant, P., Waterfield, M. D., & Riddle, P. (1988) · Nature · doi:10.1038/333560a0 · Cited by 830
Self-citationMultiple extracellular signals are required for long-term oligodendrocyte survival
Barres, B. A., Schmid, R., Sendnter, M., & Raff, M. C. (1993) · Development · doi:10.1242/dev.118.1.283 · Cited by 712
Neuronal regulation of astroglial morphology and proliferation in vitro.
Hatten, M. E. (1985) · The Journal of cell biology · doi:10.1083/jcb.100.2.384 · Cited by 592
Metadata
- Authors
- Ranscht, B., Clapshaw, P. A., Price, J., Noble, M., & Seifert, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-04
- Volume
- 79
- Issue
- 8
- Pages
- 2709-2713
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2074558188
- Cited by
- 833
- References
- 0
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Ranscht, B., Clapshaw, P. A., Price, J., Noble, M., & Seifert, W. (1982). Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.8.2709
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