PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
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Platelet-derived growth factor alpha receptor (PDGFRA)/NG2-expressing glia are distributed throughout the adult CNS. They are descended from oligodendrocyte precursors (OLPs) in the perinatal CNS, but it is not clear whether they continue to generate myelinating oligodendrocytes or other differentiated cells during normal adult life. We followed the fates of adult OLPs in Pdgfra-creER(T2)/Rosa26-YFP double-transgenic mice and found that they generated many myelinating oligodendrocytes during adulthood; >20% of all oligodendrocytes in the adult mouse corpus callosum were generated after 7 weeks of age, raising questions about the function of the late-myelinating axons. OLPs also produced some myelinating cells in the cortex, but the majority of adult-born cortical cells did not appear to myelinate. We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb.
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Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating oligodendrocytes (OLs) well into adulthood.
“Oligodendrocyte precursors (OPs) continue to proliferate and generate myelinating oligodendrocytes (OLs) well into adulthood.”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Rivers et al., 2008
At P120+7, 19.9% ± 3.2% of all optic nerve OPs (defined by NG2 immunolabeling) were YFP labeled, less than in adult corpus callosum (approximately 45%) or spinal cord (approximately 39%).
“A short time later (P120+7), 19.9% ± 3.2% of all optic nerve OPs (defined by NG2 immunolabeling) were YFP labeled (mean ±SD, n = 3 mice), less than in the adult corpus callosum (∼45%; Rivers et al., 2008) or spinal cord (∼39%; Zawadzka et al., 2010; Tripathi et al., 2010).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Rivers et al., 2008
Because the number-density of OPs within a given region does not change much with age, half of the daughters of OP divisions must either differentiate or die.
“Because the number-density of OPs within a given region does not change much with age (Rivers et al., 2008), it follows that half of the daughters of OP divisions must either differentiate (and lose OP markers) or die.”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Rivers et al., 2008
Approximately 30% of all OLs present in the corpus callosum of 8-month-old mice are generated after 7 weeks of age.
“The scale of new OL genesis in the adult is unexpectedly large: ∼30% of all OLs present in the corpus callosum of 8-month-old mice are generated after 7 weeks of age (Rivers et al., 2008; Zhu et al., 2011).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Rivers et al., 2008
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“They administrated tamoxifen at P4, P30, P45, and P180 and then analyzed the progeny after days or months to analyze whether NG2 glia produced astrocytes in the postnatal brain (Rivers et al., 2008; Kang et al., 2010; Clarke et al., 2012).”
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Self-citation
- Authors
- Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N., & Richardson, W. D.
- Affiliations
- University College London (GB)
- Corresponding author
- Richardson, William D
- Venue
- Nature Neuroscience
- Published
- 2008-10-08
- Volume
- 11
- Issue
- 12
- Pages
- 1392-1401
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3842596
- OpenAlex
- W2058915525
- Cited by
- 961
- References
- 55
- Citations by year
- 2026: 35 · 2025: 52 · 2024: 42 · 2023: 54 · 2022: 53 · 2021: 52 · 2020: 67 · 2019: 62 · 2018: 52 · 2017: 53 · 2016: 50 · 2015: 70 · 2014: 60 · 2013: 61 · 2012: 60
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eCite Digital Repository (University of Tasmania) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Wellcome Trust (080513)
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- oligodendrocyte lineage, myelinating oligodendrocytes, adult neurogenesis, piriform cortex, projection neurons, corpus callosum, cortical myelination, olfactory bulb, fate mapping
- MeSH terms
- Oligodendrocyte Transcription Factor 2, Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Bromodeoxyuridine, Cell Differentiation, Cerebral Cortex, Myelin Basic Protein, Estrogen Antagonists, Gene Expression Regulation, Humans, Luminescent Proteins, Mice, Transgenic, Nerve Tissue Proteins, Neural Pathways, Neurons, Oligodendroglia, Phosphopyruvate Hydratase, Proteins, Proteoglycans, Tamoxifen, 2',3'-Cyclic-Nucleotide Phosphodiesterases, Receptor, Platelet-Derived Growth Factor alpha, RNA, Untranslated, Mice, Receptor, Fibroblast Growth Factor, Type 3, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Adult Stem Cells, SOXE Transcription Factors
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