Formation of the Murine Endoderm

Tremblay, Kimberly D.

doi:10.1016/b978-0-12-381280-3.00001-4

Cited by 21Developmental Biology and Gene RegulationPluripotent Stem Cells ResearchRenal and related cancers

Formation of the Murine Endoderm

Tremblay, Kimberly D.·2010·Progress in Molecular Biology and Translational Science

DOI 10.1016/b978-0-12-381280-3.00001-4

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Abstract

The mammalian definitive endoderm arises as a simple epithelial sheet. This sheet of cells will eventually produce the innermost tube that comprises the entire digestive tract from the esophagus to the colon as well as the epithelial component of the digestive and respiratory organs including the thymus, thyroid, lung, liver, gallbladder, and pancreas. Thus a wide array of tissue types are derived from the early endodermal sheet, and understanding the morphological and molecular mechanisms used to produce this tissue is integral to understanding the development of all these organs. The goal of this chapter is to summarize what is known about the morphological and molecular mechanisms used to produce this embryonic germ layer. Although this chapter mainly focuses on the mechanisms used to generate the murine endoderm, supportive or suggestive data from other species, including chick, frog (Xenopus laevis), and the Zebrafish (Danio rerio) are also examined.

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The gut endoderm is the precursor of the respiratory and digestive tracts and their associated organs.
“The gut endoderm is the precursor of the respiratory and digestive tracts, and their associated organs1,2 (Fig. 1).”
From The emergent landscape of the mouse gut endoderm at single-cell resolution (2019) · cites this paper as [2]

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The emergent landscape of the mouse gut endoderm at single-cell resolution
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Authors: Tremblay, K. D.
Affiliations: University of Massachusetts Amherst (US)
Corresponding author: Tremblay, Kimberly D.
ORCID: Tremblay, Kimberly D.
Venue: Progress in Molecular Biology and Translational Science
Publisher: Elsevier
Published: 2010
Volume: 96
Pages: 1-34
ISSN: 1877-1173 (ISSN-L)
DOI: 10.1016/b978-0-12-381280-3.00001-4
OpenAlex: W2274824273
Cited by: 21
References: 146
Citations by year: 2026: 3 · 2024: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 1
FWCI: 1.55
Type: book chapter
Language: en
Open access: closed
Locations: Progress in molecular biology and translational science (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK087753)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Renal and related cancers
Keywords: definitive endoderm, endoderm formation, germ layer formation, mouse embryo, epithelial sheets, digestive tract development, organogenesis, comparative embryology
MeSH terms: Animals, Anura, Chick Embryo, Endoderm, Fishes, Morphogenesis, Mice

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Formation of the Murine Endoderm

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