Developmental expression of the putative transcription factor Egr-1 suggests that Egr-1 and c-fos are coregulated in some tissues
Abstract
We have investigated developmental expression of the gene Egr-1, which encodes a protein containing three zinc fingers. Egr-1 like c-fos is a serum inducible, early response gene, which is co-induced with c-fos in a variety of quite different situations. A single 3.7-kb RNA was detected throughout fetal mouse development, which increased in absolute levels in total fetal RNA from 9.5 to 12.5 days post coitum (p.c.). In situ hybridization to 14.5- and 17.5-day p.c. fetal tissues demonstrated Egr-1 accumulation at several specific sites. These included mesenchymal components of the developing tooth germs and salivary and nasal glands; an ectodermally derived component of the whisker pad and developing muscle, cartilage, and bone. Expression of Egr-1 in cartilage and bone showed a strikingly similar expression to previously published reports of c-fos in these tissues. High levels of Egr-1 RNA was observed at the perichondrial interface of opposing cartilaginous elements and in interstitial cells that lie in between. Bone expression was observed in membranous bone of the head, alveolar bone around the tooth germs, and at periosteal and endochondral ossification sites in the limb bones. Our data support the idea that Egr-1 and c-fos may be coregulated in vivo and together may regulate normal development of the skeleton.
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EGR1 is implicated in cranial development in animal models, and its promoter has been shown to feature a bivalent state in human embryonic cranial neural crest.
“which is implicated in cranial development (in animal models) (33, 34) and whose promoter has been recently shown to feature a bivalent state in human embryonic cranial NC (23, 35).”
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- Authors
- Mcmahon, A. P., Champion, J. E., Mcmahon, J. A., & Sukhatme, V. P.
- Affiliations
- Roche Institute of Molecular Biology, Department of Cell and Developmental Biology, Roche Research Center, Nutley, New Jersey 07110, USA
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1990-02-01
- Volume
- 108
- Issue
- 2
- Pages
- 281-287
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1924936587
- Cited by
- 141
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- EGR1, c-fos, transcription factors, zinc finger proteins, gene expression, tooth germ, salivary glands, nasal glands, whisker pad, cartilage, skeletal development, endochondral ossification, periosteal ossification, early response genes, co-regulation
- MeSH terms
- Animals, Bone and Bones, Cartilage, Embryonic and Fetal Development, Gene Expression Regulation, Muscles, Nose, Salivary Glands, Tendons, Transcription Factors, Vibrissae, Gene Expression, Mice
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